Unfolded Protein Response [signální dráha UPR]

topical
19
Terms

dráha UPR
odpověď na chybně složené proteiny
odpověď na nesprávně složené proteiny

Persistent link   https://www.medvik.cz/link/D056811
Definition

A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.

DUI
D056811 MeSH Browser
CUI
M0529267
Previous indexing
Protein Folding (1995-2009)
History note
2010
Public note
2010

Allowable subheadings

DE
drug effects 7
GE
genetics 2
IM
immunology 0
PH
physiology 3
RE
radiation effects 0

G Phenomena and Processes
G02 Chemical Phenomena 307
G02.111 Biochemical Phenomena 370
G02.111.660 Peptide Biosynthesis 43
G02.111.660.871 Protein Biosynthesis 425
G02.111.660.871.790 Protein Modification, Translational 7
G02.111.660.871.790.600 Protein Processing, Post-Translational 198
G02.111.660.871.790.600.200 ADP-Ribosylation
G02.111.660.871.790.600.250 Protein Carbamylation 1
G02.111.660.871.790.600.300 Citrullination 5
G02.111.660.871.790.600.350 Protein Carbonylation 38
G02.111.660.871.790.600.400 Protein Prenylation 6
G02.111.660.871.790.600.700 Protein Splicing 4
G02.111.660.871.790.600.925 Ubiquitination 72
G02.111.660.871.790.600.962 Unfolded Protein Response 19
G02.111.660.871.790.600.962.500 Endoplasmic Reticulum-Associated Degradation 3
G02.111.691 Protein Modification, Translational 7
G02.111.691.600 Protein Processing, Post-Translational 198
G02.111.691.600.200 ADP-Ribosylation
G02.111.691.600.250 Protein Carbamylation 1
G02.111.691.600.300 Citrullination 5
G02.111.691.600.350 Protein Carbonylation 38
G02.111.691.600.400 Protein Prenylation 6
G02.111.691.600.700 Protein Splicing 4
G02.111.691.600.775 Ubiquitination 72
G02.111.691.600.850 Unfolded Protein Response 19
G02.111.691.600.850.500 Endoplasmic Reticulum-Associated Degradation 3
G03 Metabolic Phenomena obsolete
G03.734 Peptide Biosynthesis 43
G03.734.871 Protein Biosynthesis 425
G03.734.871.790 Protein Modification, Translational 7
G03.734.871.790.600 Protein Processing, Post-Translational 198
G03.734.871.790.600.200 ADP-Ribosylation
G03.734.871.790.600.250 Protein Carbamylation 1
G03.734.871.790.600.300 Citrullination 5
G03.734.871.790.600.350 Protein Carbonylation 38
G03.734.871.790.600.400 Protein Prenylation 6
G03.734.871.790.600.700 Protein Splicing 4
G03.734.871.790.600.831 Ubiquitination 72
G03.734.871.790.600.850 Unfolded Protein Response 19
G03.734.871.790.600.850.500 Endoplasmic Reticulum-Associated Degradation 3
G04 Cell Physiological Phenomena 514
G04.434 Endoplasmic Reticulum Stress 52
G04.434.500 Unfolded Protein Response 19
G04.434.500.500 Endoplasmic Reticulum-Associated Degradation 3
G05 Genetic Phenomena 135
G05.308 Gene Expression Regulation 1 073
G05.308.670 Protein Modification, Translational 7
G05.308.670.600 Protein Processing, Post-Translational 198
G05.308.670.600.200 ADP-Ribosylation
G05.308.670.600.250 Protein Carbamylation 1
G05.308.670.600.300 Citrullination 5
G05.308.670.600.350 Protein Carbonylation 38
G05.308.670.600.400 Protein Prenylation 6
G05.308.670.600.700 Protein Splicing 4
G05.308.670.600.831 Ubiquitination 72
G05.308.670.600.850 Unfolded Protein Response 19
G05.308.670.600.850.500 Endoplasmic Reticulum-Associated Degradation 3

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