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Autor
Al Hamed, Rama 1 Baron, Frederic 1 Bazarbachi, Abdul Hamid 1 Bazarbachi, Ali 1 Bernasconi, Paolo 1 Carreras, Enric 1 Chantepie, Sylvain P 1 Ciceri, Fabio 1 Corbacioglu, Selim 1 Gandemer, Virginie 1 Guffroy, Blandine 1 Halaburda, Kazimierz 1 Jindra, Pavel 1 Labopin, Myriam 1 Labussiere, Helene 1 Lopez-Corral, Lucia 1 Loschi, Michael 1 Mohty, Mohamad 1 Nagler, Arnon 1 Nikolousis, Manos 1
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Pracoviště
BMT Unit Department of Hematology IDI... 1 Caen University Hospital Hematology I... 1 Centro de Investigación del Cáncer IB... 1 Department of Haematology Sheffield T... 1 Department of Haematology and Oncolog... 1 Department of Hematology Hopitaux Uni... 1 Department of Hematology Institute of... 1 Department of Hematology Saint Luc Un... 1 Department of Hematology School of Me... 1 Department of Hematology The Collabor... 1 Department of Hematology University a... 1 Department of Internal Medicine Ameri... 1 Department of Medical Oncology Dana F... 1 Department of Pediatric Hematology On... 1 Department of Pediatric Oncology and ... 1 Division of Hematology Oncology Vande... 1 Division of Infectious Diseases Brigh... 1 Département d'Hématologie Hospices Ci... 1 HSCT Unit SC Ematologia Fondazione IR... 1 Heartlands Hospital Birmingham UK 1
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Autor
Al Hamed, Rama 1 Baron, Frederic 1 Bazarbachi, Abdul Hamid 1 Bazarbachi, Ali 1 Bernasconi, Paolo 1 Carreras, Enric 1 Chantepie, Sylvain P 1 Ciceri, Fabio 1 Corbacioglu, Selim 1 Gandemer, Virginie 1 Guffroy, Blandine 1 Halaburda, Kazimierz 1 Jindra, Pavel 1 Labopin, Myriam 1 Labussiere, Helene 1 Lopez-Corral, Lucia 1 Loschi, Michael 1 Mohty, Mohamad 1 Nagler, Arnon 1 Nikolousis, Manos 1
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Pracoviště
BMT Unit Department of Hematology IDI... 1 Caen University Hospital Hematology I... 1 Centro de Investigación del Cáncer IB... 1 Department of Haematology Sheffield T... 1 Department of Haematology and Oncolog... 1 Department of Hematology Hopitaux Uni... 1 Department of Hematology Institute of... 1 Department of Hematology Saint Luc Un... 1 Department of Hematology School of Me... 1 Department of Hematology The Collabor... 1 Department of Hematology University a... 1 Department of Internal Medicine Ameri... 1 Department of Medical Oncology Dana F... 1 Department of Pediatric Hematology On... 1 Department of Pediatric Oncology and ... 1 Division of Hematology Oncology Vande... 1 Division of Infectious Diseases Brigh... 1 Département d'Hématologie Hospices Ci... 1 HSCT Unit SC Ematologia Fondazione IR... 1 Heartlands Hospital Birmingham UK 1
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- Bazarbachi, Abdul Hamid
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Al Hamed, Rama
Autor Al Hamed, Rama Sorbonne University, Department of Clinical Hematology and Cellular Therapy, Saint Antoine Hospital, INSERM UMR 938, Paris, France Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA Division of Infectious Diseases, Brigham & Women's, Harvard Medical School, Boston, MA, USA
- Labopin, Myriam
- Halaburda, Kazimierz
- Labussiere, Helene
- Bernasconi, Paolo
- Schroyens, Wilfried
- Gandemer, Virginie
- Schaap, Nicolaas P M
- Loschi, Michael
NLK
Free Medical Journals
od 1997 do Před 1 rokem
Freely Accessible Science Journals
od 1997 do Před 1 rokem
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
33208915
DOI
10.1038/s41409-020-01135-3
Knihovny.cz E-zdroje
Allogeneic hematopoietic cell transplantation (alloHCT) is a complex, potentially fatal therapy featuring a myriad of complications. Triggering event(s) of such complications vary significantly, but often a so-called "multi-organ failure" (MOF) is reported as the leading cause of death. The identification of the exact trigger of MOF is critical towards early and disease-specific intervention to improve outcome. We examined data from 202 alloHCT patients reported to have died of MOF from the EBMT registry aiming to determine their exact cause of death focusing on veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) due to its life-threatening, often difficult to capture yet preventable nature. We identified a total of 70 patients (35%) for whom VOD/SOS could be considered as trigger for MOF and leading cause of death, among which 48 (69%) were previously undiagnosed. Multivariate analysis highlighted history of hepatic comorbidity or gentuzumab use and disease status beyond CR1 as the only significant factors predictive of VOD/SOS incidence (OR = 6.6; p = 0.001 and OR = 3.3; p = 0.004 respectively). VOD/SOS-related MOF was widely under-reported, accounting for 27% of deaths attributed to MOF of unknown origin without a previous VOD/SOS diagnosis. Our results suggest most missed cases developed late VOD/SOS beyond 21 days post-alloHCT, highlighting the importance of the newly revised EBMT criteria.
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