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Autor
Bendak, Katerina 1 Cowley, Mark J 1 Cross, Siobhan 1 Dalla Pozza, Luciano 1 Fraser, Chris 1 Heatley, Susan L 1 Henderson, Michelle J 1 Hovorková, Lenka 1 Huang, Libby 1 Khaw, Seong Lin 1 Law, Tamara 1 Moore, Andrew S 1 Muskovic, Walter 1 Norris, Murray D 1 Revesz, Tom 1 Shaw, Peter J 1 Sutton, Rosemary 1 Trahair, Toby N 1 Venn, Nicola C 1 White, Deborah L 1
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Pracoviště
Blood and Bone Marrow Transplant Prog... 1 CLIP Childhood Leukaemia Investigatio... 1 Cancer Centre for Children The Childr... 1 Children's Cancer Centre The Royal Ch... 1 Children's Haematology Oncology Centr... 1 Computational Biology Children's Canc... 1 Department of Clinical Haematology an... 1 Department of Paediatric Haematology ... 1 Kids Cancer Centre Sydney Children's ... 1 Molecular Diagnostics Children's Canc... 1 Paediatric Oncology Queensland Childr... 1 Precision Medicine Theme South Austra... 1 School of Medicine University of Adel... 1 School of Women's and Children's Heal... 1 University Hospital Motol Prague Czec... 1
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Autor
Bendak, Katerina 1 Cowley, Mark J 1 Cross, Siobhan 1 Dalla Pozza, Luciano 1 Fraser, Chris 1 Heatley, Susan L 1 Henderson, Michelle J 1 Hovorková, Lenka 1 Huang, Libby 1 Khaw, Seong Lin 1 Law, Tamara 1 Moore, Andrew S 1 Muskovic, Walter 1 Norris, Murray D 1 Revesz, Tom 1 Shaw, Peter J 1 Sutton, Rosemary 1 Trahair, Toby N 1 Venn, Nicola C 1 White, Deborah L 1
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Pracoviště
Blood and Bone Marrow Transplant Prog... 1 CLIP Childhood Leukaemia Investigatio... 1 Cancer Centre for Children The Childr... 1 Children's Cancer Centre The Royal Ch... 1 Children's Haematology Oncology Centr... 1 Computational Biology Children's Canc... 1 Department of Clinical Haematology an... 1 Department of Paediatric Haematology ... 1 Kids Cancer Centre Sydney Children's ... 1 Molecular Diagnostics Children's Canc... 1 Paediatric Oncology Queensland Childr... 1 Precision Medicine Theme South Austra... 1 School of Medicine University of Adel... 1 School of Women's and Children's Heal... 1 University Hospital Motol Prague Czec... 1
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NLK
Free Medical Journals
od 1947 do Před 1 rokem
Freely Accessible Journals
od 1947 do Před 1 rokem
PubMed Central
od 1947 do Před 1 rokem
Europe PubMed Central
od 1947 do Před 1 rokem
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1947-01-01
Open Access Digital Library
od 1999-01-01
Nursing & Allied Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
35650277
DOI
10.1038/s41416-022-01806-6
Knihovny.cz E-zdroje
BACKGROUND: ABL-class fusions including NUP214-ABL1 and EBF1-PDGFRB occur in high risk acute lymphoblastic leukaemia (ALL) with gene expression patterns similar to BCR-ABL-positive ALL. Our aim was to evaluate new DNA-based measurable residual disease (MRD) tests detecting these fusions and IKZF1-deletions in comparison with conventional immunoglobulin/T-cell receptor (Ig/TCR) markers. METHODS: Precise genomic breakpoints were defined from targeted or whole genome next generation sequencing for ABL-fusions and BCR-ABL1. Quantitative PCR assays were designed and used to re-measure MRD in remission bone marrow samples previously tested using Ig/TCR markers. All MRD testing complied with EuroMRD guidelines. RESULTS: ABL-class patients had 46% 5year event-free survival and 79% 5year overall survival. All had sensitive fusion tests giving high concordance between Ig/TCR and ABL-class fusion results (21 patients, n = 257 samples, r2 = 0.9786, P < 0.0001) and Ig/TCR and IKZF1-deletion results (9 patients, n = 143 samples, r2 = 0.9661, P < 0.0001). In contrast, in BCR-ABL1 patients, Ig/TCR and BCR-ABL1 tests were discordant in 32% (40 patients, n = 346 samples, r2 = 0.4703, P < 0.0001) and IKZF1-deletion results were closer to Ig/TCR (25 patients, n = 176, r2 = 0.8631, P < 0.0001). CONCLUSIONS: MRD monitoring based on patient-specific assays detecting gene fusions or recurrent assays for IKZF1-deletions is feasible and provides good alternatives to Ig/TCR tests to monitor MRD in ABL-class ALL.
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