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Autor
Adami, Hans-Olov 1 Albanes, Demetrius 1 Angelucci, Emanuele 1 Ansell, Stephen M 1 Asmann, Yan W 1 Becker, Nikolaus 1 Benavente, Yolanda 1 Bernatsky, Sasha 1 Berndt, Sonja I 1 Bertrand, Kimberly A 1 Birmann, Brenda M 1 Boeing, Heiner 1 Boffetta, Paolo 1 Bracci, Paige M 1 Brennan, Paul 1 Brooks-Wilson, Angela R 1 Cerhan, James R 1 Chanock, Stephen J 1 Clarke, Ann E 1 Clavel, Jacqueline 1
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Pracoviště
Arthritis and Clinical Immunology Res... 1 BC Cancer Research Centre and School ... 1 Cancer Epidemiology Centre Cancer Cou... 1 Cancer Epidemiology Research Programm... 1 Cancer Epidemiology Research Programm... 1 Center for Chronic Immunodeficiency U... 1 Centre Heni Becquerel Université de R... 1 Centre for Big Data Research in Healt... 1 Channing Division of Network Medicine... 1 Chronic Disease Prevention Unit Natio... 1 Clinical Epidemiology Unit Department... 1 Danish Cancer Society Research Center... 1 Department of Biomedical Science Univ... 1 Department of Biostatistics Yale Scho... 1 Department of Cancer Epidemiology and... 1 Department of Computational Biology S... 1 Department of Environmental Health Sc... 1 Department of Environmental and Occup... 1 Department of Epidemiology Brown Scho... 1 Department of Epidemiology German Ins... 1
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Autor
Adami, Hans-Olov 1 Albanes, Demetrius 1 Angelucci, Emanuele 1 Ansell, Stephen M 1 Asmann, Yan W 1 Becker, Nikolaus 1 Benavente, Yolanda 1 Bernatsky, Sasha 1 Berndt, Sonja I 1 Bertrand, Kimberly A 1 Birmann, Brenda M 1 Boeing, Heiner 1 Boffetta, Paolo 1 Bracci, Paige M 1 Brennan, Paul 1 Brooks-Wilson, Angela R 1 Cerhan, James R 1 Chanock, Stephen J 1 Clarke, Ann E 1 Clavel, Jacqueline 1
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Pracoviště
Arthritis and Clinical Immunology Res... 1 BC Cancer Research Centre and School ... 1 Cancer Epidemiology Centre Cancer Cou... 1 Cancer Epidemiology Research Programm... 1 Cancer Epidemiology Research Programm... 1 Center for Chronic Immunodeficiency U... 1 Centre Heni Becquerel Université de R... 1 Centre for Big Data Research in Healt... 1 Channing Division of Network Medicine... 1 Chronic Disease Prevention Unit Natio... 1 Clinical Epidemiology Unit Department... 1 Danish Cancer Society Research Center... 1 Department of Biomedical Science Univ... 1 Department of Biostatistics Yale Scho... 1 Department of Cancer Epidemiology and... 1 Department of Computational Biology S... 1 Department of Environmental Health Sc... 1 Department of Environmental and Occup... 1 Department of Epidemiology Brown Scho... 1 Department of Epidemiology German Ins... 1
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Free Medical Journals od 2014
Freely Accessible Journals od 2014
PubMed Central od 2014
Europe PubMed Central od 2014
ProQuest Central od 2014-01-01
Open Access Digital Library od 2014-01-01
Open Access Digital Library od 2014-01-01
Health & Medicine (ProQuest) od 2014-01-01
ROAD: Directory of Open Access Scholarly Resources od 2014
PubMed
29214033
DOI
10.1136/lupus-2016-000187
Knihovny.cz E-zdroje
Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.