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Pracoviště: Department of Biomedical Metabolic and Neural S...

2 záznamů v Medvik Filtry

Článek

Data-Driven Phenotyping of Central Disorders of Hypersomnolence With Unsupervised Clustering

Gool, Jari K
Autor Gool, Jari K From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.) Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland Sleep Medicine Center Kempenhaeghe (S.O.), Heeze Eindhoven University of Technology (S.O.), the Netherlands Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón University Complutense of Madrid (R.P.-A.), Spain Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy. j.gool@amsterdamumc.nl
Zhang, Zhongxing
Autor Zhang, Zhongxing From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.) Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland Sleep Medicine Center Kempenhaeghe (S.O.), Heeze Eindhoven University of Technology (S.O.), the Netherlands Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón University Complutense of Madrid (R.P.-A.), Spain Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy
Oei, Martijn S S L
Autor Oei, Martijn S S L From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.) Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland Sleep Medicine Center Kempenhaeghe (S.O.), Heeze Eindhoven University of Technology (S.O.), the Netherlands Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón University Complutense of Madrid (R.P.-A.), Spain Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy
Mathias, Stephanie
Autor Mathias, Stephanie From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.) Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland Sleep Medicine Center Kempenhaeghe (S.O.), Heeze Eindhoven University of Technology (S.O.), the Netherlands Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón University Complutense of Madrid (R.P.-A.), Spain Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy
Dauvilliers, Yves
Autor Dauvilliers, Yves From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.) Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland Sleep Medicine Center Kempenhaeghe (S.O.), Heeze Eindhoven University of Technology (S.O.), the Netherlands Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón University Complutense of Madrid (R.P.-A.), Spain Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy
Mayer, Geert
Autor Mayer, Geert From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.) Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland Sleep Medicine Center Kempenhaeghe (S.O.), Heeze Eindhoven University of Technology (S.O.), the Netherlands Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón University Complutense of Madrid (R.P.-A.), Spain Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy
Plazzi, Giuseppe
Autor Plazzi, Giuseppe From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.) Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland Sleep Medicine Center Kempenhaeghe (S.O.), Heeze Eindhoven University of Technology (S.O.), the Netherlands Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón University Complutense of Madrid (R.P.-A.), Spain Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy
Del Rio-Villegas, Rafael
Autor Del Rio-Villegas, Rafael From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.) Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland Sleep Medicine Center Kempenhaeghe (S.O.), Heeze Eindhoven University of Technology (S.O.), the Netherlands Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón University Complutense of Madrid (R.P.-A.), Spain Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy
Cano, Joan Santamaria
Autor Cano, Joan Santamaria From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.) Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland Sleep Medicine Center Kempenhaeghe (S.O.), Heeze Eindhoven University of Technology (S.O.), the Netherlands Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón University Complutense of Madrid (R.P.-A.), Spain Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy
Šonka, Karel
Autor Šonka, Karel From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.) Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland Sleep Medicine Center Kempenhaeghe (S.O.), Heeze Eindhoven University of Technology (S.O.), the Netherlands Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón University Complutense of Madrid (R.P.-A.), Spain Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy

Neurology. 2022 ; 98 (23) : e2387-e2400. [pub] 20220418

ISSN 1526-632X
Medvik
Zdroj

BACKGROUND AND OBJECTIVES: Recent studies fueled doubts as to whether all currently defined central disorders of hypersomnolence are stable entities, especially narcolepsy type 2 and idiopathic hypersomnia. New reliable biomarkers are needed, and the question arises of whether current diagnostic criteria of hypersomnolence disorders should be reassessed. The main aim of this data-driven observational study was to see whether data-driven algorithms would segregate narcolepsy type 1 and identify more reliable subgrouping of individuals without cataplexy with new clinical biomarkers. METHODS: We used agglomerative hierarchical clustering, an unsupervised machine learning algorithm, to identify distinct hypersomnolence clusters in the large-scale European Narcolepsy Network database. We included 97 variables, covering all aspects of central hypersomnolence disorders such as symptoms, demographics, objective and subjective sleep measures, and laboratory biomarkers. We specifically focused on subgrouping of patients without cataplexy. The number of clusters was chosen to be the minimal number for which patients without cataplexy were put in distinct groups. RESULTS: We included 1,078 unmedicated adolescents and adults. Seven clusters were identified, of which 4 clusters included predominantly individuals with cataplexy. The 2 most distinct clusters consisted of 158 and 157 patients, were dominated by those without cataplexy, and among other variables, significantly differed in presence of sleep drunkenness, subjective difficulty awakening, and weekend-week sleep length difference. Patients formally diagnosed as having narcolepsy type 2 and idiopathic hypersomnia were evenly mixed in these 2 clusters. DISCUSSION: Using a data-driven approach in the largest study on central disorders of hypersomnolence to date, our study identified distinct patient subgroups within the central disorders of hypersomnolence population. Our results contest inclusion of sleep-onset REM periods in diagnostic criteria for people without cataplexy and provide promising new variables for reliable diagnostic categories that better resemble different patient phenotypes. Cluster-guided classification will result in a more solid hypersomnolence classification system that is less vulnerable to instability of single features.

MeSH
idiopatická hypersomnie * diagnóza MeSH
kataplexie * diagnóza MeSH
lidé MeSH
mladiství MeSH
narkolepsie * diagnóza farmakoterapie MeSH
poruchy nadměrné spavosti * diagnóza epidemiologie MeSH
shluková analýza MeSH
Check Tag
lidé MeSH
mladiství MeSH
Publikační typ
časopisecké články MeSH
pozorovací studie MeSH

Článek

Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder

Neurology. 2021 ; 96 (10) : e1402-e1412. [pub] 20210104

ISSN 1526-632X
Medvik
Zdroj

OBJECTIVE: To examine the role of genes identified through genome-wide association studies (GWASs) of Parkinson disease (PD) in the risk of isolated REM sleep behavior disorder (iRBD). METHODS: We fully sequenced 25 genes previously identified in GWASs of PD in a total of 1,039 patients with iRBD and 1,852 controls. The role of rare heterozygous variants in these genes was examined with burden tests. The contribution of biallelic variants was further tested. To examine the potential effect of rare nonsynonymous BST1 variants on the protein structure, we performed in silico structural analysis. Finally, we examined the association of common variants using logistic regression adjusted for age and sex. RESULTS: We found an association between rare heterozygous nonsynonymous variants in BST1 and iRBD (p = 0.0003 at coverage >50× and 0.0004 at >30×), driven mainly by 3 nonsynonymous variants (p.V85M, p.I101V, and p.V272M) found in 22 (1.2%) controls vs 2 (0.2%) patients. All 3 variants seem to be loss-of-function variants with a potential effect on the protein structure and stability. Rare noncoding heterozygous variants in LAMP3 were also associated with iRBD (p = 0.0006 at >30×). We found no association between rare heterozygous variants in the rest of genes and iRBD. Several carriers of biallelic variants were identified, yet there was no overrepresentation in iRBD. CONCLUSION: Our results suggest that rare coding variants in BST1 and rare noncoding variants in LAMP3 are associated with iRBD. Additional studies are required to replicate these results and to examine whether loss of function of BST1 could be a therapeutic target.

MeSH
ADP-ribosylcyklasa genetika MeSH
CD antigeny genetika MeSH
celogenomová asociační studie MeSH
databáze genetické MeSH
genetická variace MeSH
GPI-vázané proteiny genetika MeSH
heterozygot MeSH
lidé středního věku MeSH
lidé MeSH
membránové glykoproteiny asociované s lyzozomy genetika MeSH
nádorové proteiny genetika MeSH
počítačová simulace MeSH
polysomnografie MeSH
porucha chování v REM spánku epidemiologie genetika MeSH
sekundární struktura proteinů MeSH
senioři MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

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