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Autor
Atıcı, Serkan 1 Badali, Hamid 1 Baddley, John W 1 Benítez-Peñuela, Miguel-Ángel 1 Cesaro, Simone 1 Chakrabarti, Arunaloke 1 Chander, Jagdish 1 Chen, Sharon C-A 1 Cornely, Oliver A 1 Desoubeaux, Guillaume 1 Dupont, Damien 1 Falces-Romero, Iker 1 García-Rodríguez, Julio 1 González, Gloria M 1 Hatvani, Lóránt 1 Herbrecht, Raoul 1 Hoenigl, Martin 1 Ingram, Paul R 1 Kindo, Anupma 1 Klimko, Nikolai 1
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Center for Molecular Medicine Cologne... 1 Center of Microbiological Research of... 1 Centre d'Etude des Pathologies Respir... 1 Centre for Diseases and Microbiology ... 1 Clinical Microbiology and Parasitolog... 1 Clinical Trials Centre Cologne Univer... 1 Clinical and Translational Fungal Wor... 1 Department of Infectious Diseases Roy... 1 Department of Internal Medicine Divis... 1 Department of Internal Medicine Divis... 1 Department of Internal Medicine Hemat... 1 Department of Medical Microbiology Po... 1 Department of Medical Microbiology an... 1 Department of Medicine Division of In... 1 Department of Medicine Section of Inf... 1 Department of Microbiology Faculty of... 1 Department of Microbiology Government... 1 Department of Microbiology School of ... 1 Department of Microbiology Sri Ramach... 1 Department of Oncology and Hematology... 1
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Autor
Atıcı, Serkan 1 Badali, Hamid 1 Baddley, John W 1 Benítez-Peñuela, Miguel-Ángel 1 Cesaro, Simone 1 Chakrabarti, Arunaloke 1 Chander, Jagdish 1 Chen, Sharon C-A 1 Cornely, Oliver A 1 Desoubeaux, Guillaume 1 Dupont, Damien 1 Falces-Romero, Iker 1 García-Rodríguez, Julio 1 González, Gloria M 1 Hatvani, Lóránt 1 Herbrecht, Raoul 1 Hoenigl, Martin 1 Ingram, Paul R 1 Kindo, Anupma 1 Klimko, Nikolai 1
- Organizace
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Pracoviště
Center for Molecular Medicine Cologne... 1 Center of Microbiological Research of... 1 Centre d'Etude des Pathologies Respir... 1 Centre for Diseases and Microbiology ... 1 Clinical Microbiology and Parasitolog... 1 Clinical Trials Centre Cologne Univer... 1 Clinical and Translational Fungal Wor... 1 Department of Infectious Diseases Roy... 1 Department of Internal Medicine Divis... 1 Department of Internal Medicine Divis... 1 Department of Internal Medicine Hemat... 1 Department of Medical Microbiology Po... 1 Department of Medical Microbiology an... 1 Department of Medicine Division of In... 1 Department of Medicine Section of Inf... 1 Department of Microbiology Faculty of... 1 Department of Microbiology Government... 1 Department of Microbiology School of ... 1 Department of Microbiology Sri Ramach... 1 Department of Oncology and Hematology... 1
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Salmanton-García, Jon
Autor Salmanton-García, Jon University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), Herderstrasse 52-54, 50931 Cologne, Germany. Electronic address: jon.salmanton-garcia@uk-koeln.de
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Koehler, Philipp
Autor Koehler, Philipp University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), Herderstrasse 52-54, 50931 Cologne, Germany University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany
- Kindo, Anupma
- Falces-Romero, Iker
- García-Rodríguez, Julio
- Ráčil, Zdeněk
- Chen, Sharon C-A
- Klimko, Nikolai
- Desoubeaux, Guillaume
- Thompson, George R
OBJECTIVES: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. METHODS: Extremely rare IFI collected in the FungiScopeⓇ registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. RESULTS: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScopeⓇ. Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. CONCLUSIONS: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens.
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