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Autor
Aufricht, Christoph 1 Battelino, Nina 1 Bjerre, Anna 1 Boehm, Michael 1 Bonthuis, Marjolein 1 Edvardsson, Vidar O 1 Groothoff, Jaap 1 Harambat, Jérôme 1 Herthelius, Maria 1 Hubmann, Holger 1 Jager, Kitty J 1 Jahnukainen, Timo 1 Laube, Guido F 1 Mattozzi, Francesca 1 Molchanova, Elena A 1 Muñoz, Marina 1 Noyan, Aytul 1 Pape, Lars 1 Printza, Nikoleta 1 Reusz, George 1
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Pracoviště
1st Department of Pediatrics Semmelwe... 1 1st Pediatric Department Aristotle Un... 1 Children's Medical Center Landspitali... 1 Department of Kidney Transplantation ... 1 Department of Nephrology Kidney Trans... 1 Department of Nephrology University C... 1 Department of Pediatric Nephrology Am... 1 Department of Pediatric Nephrology Er... 1 Department of Pediatric Nephrology Ev... 1 Department of Pediatric Nephrology Fa... 1 Department of Pediatric Nephrology Ha... 1 Department of Pediatric Nephrology Un... 1 Department of Pediatric Nephrology Un... 1 Department of Pediatric Nephrology an... 1 Department of Pediatrics 2nd Medical ... 1 Department of Pediatrics Medical Univ... 1 Division of Paediatric and Adolescent... 1 Division of Pediatric Nephrology and ... 1 Division of Pediatrics Department of ... 1 ESPN ERA EDTA Registry Department of ... 1
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Autor
Aufricht, Christoph 1 Battelino, Nina 1 Bjerre, Anna 1 Boehm, Michael 1 Bonthuis, Marjolein 1 Edvardsson, Vidar O 1 Groothoff, Jaap 1 Harambat, Jérôme 1 Herthelius, Maria 1 Hubmann, Holger 1 Jager, Kitty J 1 Jahnukainen, Timo 1 Laube, Guido F 1 Mattozzi, Francesca 1 Molchanova, Elena A 1 Muñoz, Marina 1 Noyan, Aytul 1 Pape, Lars 1 Printza, Nikoleta 1 Reusz, George 1
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Pracoviště
1st Department of Pediatrics Semmelwe... 1 1st Pediatric Department Aristotle Un... 1 Children's Medical Center Landspitali... 1 Department of Kidney Transplantation ... 1 Department of Nephrology Kidney Trans... 1 Department of Nephrology University C... 1 Department of Pediatric Nephrology Am... 1 Department of Pediatric Nephrology Er... 1 Department of Pediatric Nephrology Ev... 1 Department of Pediatric Nephrology Fa... 1 Department of Pediatric Nephrology Ha... 1 Department of Pediatric Nephrology Un... 1 Department of Pediatric Nephrology Un... 1 Department of Pediatric Nephrology an... 1 Department of Pediatrics 2nd Medical ... 1 Department of Pediatrics Medical Univ... 1 Division of Paediatric and Adolescent... 1 Division of Pediatric Nephrology and ... 1 Division of Pediatrics Department of ... 1 ESPN ERA EDTA Registry Department of ... 1
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BACKGROUND: Many centers accept a minimum body weight of 10 kg as threshold for kidney transplantation (Tx) in children. As solid evidence for clinical outcomes in multinational studies is lacking, we evaluated practices and outcomes in European children weighing below 10 kg at Tx. METHODS: Data were obtained from the European Society of Paediatric Nephrology/European Renal Association and European Dialysis and Transplant Association Registry on all children who started kidney replacement therapy at <2.5 y of age and received a Tx between 2000 and 2016. Weight at Tx was categorized (<10 versus ≥10 kg) and Cox regression analysis was used to evaluate its association with graft survival. RESULTS: One hundred of the 601 children received a Tx below a weight of 10 kg during the study period. Primary renal disease groups were equal, but Tx <10 kg patients had lower pre-Tx weight gain per year (0.2 versus 2.1 kg; P < 0.001) and had a higher preemptive Tx rate (23% versus 7%; P < 0.001). No differences were found for posttransplant estimated glomerular filtration rates trajectories (P = 0.23). The graft failure risk was higher in Tx <10 kg patients at 1 y (graft survival: 90% versus 95%; hazard ratio, 3.84; 95% confidence interval, 1.24-11.84), but not at 5 y (hazard ratio, 1.71; 95% confidence interval, 0.68-4.30). CONCLUSIONS: Despite a lower 1-y graft survival rate, graft function, and survival at 5 y were identical in Tx <10 kg patients when compared with Tx ≥10 kg patients. Our results suggest that early transplantation should be offered to a carefully selected group of patients weighing <10 kg.
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