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Autor
Avivi, Irit 1 Barth, Peter 1 Bittrich, Max 1 Castillo, Jorge J 1 Chappell, Aimee 1 Chhabra, Saurabh 1 Chim, Chor S 1 Cohen, Yael 1 Coriu, Daniel 1 Czepiel, Jacek 1 Delforge, Michel 1 Długosz-Danecka, Monika 1 Gentile, Massimo 1 Goldberg, Stuart L 1 Goldman-Mazur, Sarah 1 González-Calle, Veronica 1 Gozzetti, Alessandro 1 Grząśko, Norbert 1 Hari, Parameswaran 1 Hus, Iwona 1
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Pracoviště
4th Department of Internal Medicine H... 1 Complejo Asistencial de Avila Avila S... 1 Cota Inc Boston MA USA 1 Dana Farber Cancer Institute Harvard ... 1 Department of Experimental Hematology... 1 Department of Experimental Hematology... 1 Department of Hematology Collegium Me... 1 Department of Hematology Fundeni Clin... 1 Department of Hematology Jagiellonian... 1 Department of Hematology Oncology Med... 1 Department of Hematology Oncology and... 1 Department of Hematology SPZOZ ZSM Ch... 1 Department of Hematology St John's Ca... 1 Department of Hematology UZ Leuven Le... 1 Department of Hematology Wroclaw Medi... 1 Department of Hematology and Stem Cel... 1 Department of Infectious and Tropical... 1 Department of Internal Medicine 2 Uni... 1 Department of Medicine Queen Mary Hos... 1 Department of Medicine Warren Alpert ... 1
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Autor
Avivi, Irit 1 Barth, Peter 1 Bittrich, Max 1 Castillo, Jorge J 1 Chappell, Aimee 1 Chhabra, Saurabh 1 Chim, Chor S 1 Cohen, Yael 1 Coriu, Daniel 1 Czepiel, Jacek 1 Delforge, Michel 1 Długosz-Danecka, Monika 1 Gentile, Massimo 1 Goldberg, Stuart L 1 Goldman-Mazur, Sarah 1 González-Calle, Veronica 1 Gozzetti, Alessandro 1 Grząśko, Norbert 1 Hari, Parameswaran 1 Hus, Iwona 1
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Pracoviště
4th Department of Internal Medicine H... 1 Complejo Asistencial de Avila Avila S... 1 Cota Inc Boston MA USA 1 Dana Farber Cancer Institute Harvard ... 1 Department of Experimental Hematology... 1 Department of Experimental Hematology... 1 Department of Hematology Collegium Me... 1 Department of Hematology Fundeni Clin... 1 Department of Hematology Jagiellonian... 1 Department of Hematology Oncology Med... 1 Department of Hematology Oncology and... 1 Department of Hematology SPZOZ ZSM Ch... 1 Department of Hematology St John's Ca... 1 Department of Hematology UZ Leuven Le... 1 Department of Hematology Wroclaw Medi... 1 Department of Hematology and Stem Cel... 1 Department of Infectious and Tropical... 1 Department of Internal Medicine 2 Uni... 1 Department of Medicine Queen Mary Hos... 1 Department of Medicine Warren Alpert ... 1
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PubMed
32306794
DOI
10.1080/10428194.2020.1749605
Knihovny.cz E-zdroje
The MAF translocations, t(14;16) and t(14;20), are considered as adverse prognostic factors based on few studies with small sample sizes. We report on their prognostic impact in a large group of 254 patients - 223 (87.8%) with t(14;16) and 31 (12.2%) with t(14;20). There were no intergroup differences in survival estimates. Median progression-free survival was 16.6 months for t(14;16) and 24.9 months for t(14;20) (p = 0.28). Median overall survival (OS) was 54.0 months and 49.0 months, respectively (p = 0.62). Median OS in patients who underwent double autologous stem cell transplantation (ASCT) was 107.0 months versus 60.0 months in patients who received single ASCT (p < 0.001). ISS 3 was associated with shorter OS (HR = 1.89; 95% CI 1.24-3.19; p = 0.005) in Cox analysis. Our study suggests that t(14;20) should be considered as an adverse factor of equal prognostic implication to t(14;16).
- MeSH
- autologní transplantace MeSH
- lidé MeSH
- mnohočetný myelom * diagnóza genetika terapie MeSH
- přežití po terapii bez příznaků nemoci MeSH
- prognóza MeSH
- retrospektivní studie MeSH
- transplantace hematopoetických kmenových buněk * MeSH
- výsledek terapie MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
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