-
Autor
Agudo, Antonio 1 Ahrens, Wolfgang 1 Alemany, Laia 1 Brennan, Paul 1 Canova, Cristina 1 Conway, David I 1 Diergaarde, Brenda 1 Hayes, D Neil 1 Healy, Claire M 1 Heijne, Janneke C M 1 Holcátová, Ivana 1 Hueniken, Katrina 1 Hung, Rayjean J 1 Kusters, Johannes M A 1 Lagiou, Areti 1 Lagiou, Pagona 1 Liu, Geoffrey 1 Macfarlane, Gary J 1 McKay, James D 1 Ness, Andrew 1
-
Pracoviště
1st Faculty of Medicine Institute of ... 1 Bristol Dental School University of B... 1 Centre for Infectious Diseases Contro... 1 Centro de Investigación Biomédica en ... 1 Centro di Riferimento Oncologico di A... 1 Dalla Lana School of Public Health Un... 1 Department of Cellular Pathology Roya... 1 Department of Infectious Diseases Pub... 1 Department of Social Medicine Care an... 1 Division of Medical Oncology and Cent... 1 Epidemiology Group School of Medicine... 1 Genomic Epidemiology Group Internatio... 1 Infections and Cancer Epidemiology Ge... 1 Institute for Infection and Immunity ... 1 NIHR Bristol Biomedical Research Cent... 1 Nutrition and Cancer Group Epidemiolo... 1 Princess Margaret Cancer Centre Temer... 1 Prosserman Centre for Population Heal... 1 Reference Center for Epidemiology and... 1 School of Medicine Dentistry and Nurs... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Vlastník
-
Autor
Agudo, Antonio 1 Ahrens, Wolfgang 1 Alemany, Laia 1 Brennan, Paul 1 Canova, Cristina 1 Conway, David I 1 Diergaarde, Brenda 1 Hayes, D Neil 1 Healy, Claire M 1 Heijne, Janneke C M 1 Holcátová, Ivana 1 Hueniken, Katrina 1 Hung, Rayjean J 1 Kusters, Johannes M A 1 Lagiou, Areti 1 Lagiou, Pagona 1 Liu, Geoffrey 1 Macfarlane, Gary J 1 McKay, James D 1 Ness, Andrew 1
-
Pracoviště
1st Faculty of Medicine Institute of ... 1 Bristol Dental School University of B... 1 Centre for Infectious Diseases Contro... 1 Centro de Investigación Biomédica en ... 1 Centro di Riferimento Oncologico di A... 1 Dalla Lana School of Public Health Un... 1 Department of Cellular Pathology Roya... 1 Department of Infectious Diseases Pub... 1 Department of Social Medicine Care an... 1 Division of Medical Oncology and Cent... 1 Epidemiology Group School of Medicine... 1 Genomic Epidemiology Group Internatio... 1 Infections and Cancer Epidemiology Ge... 1 Institute for Infection and Immunity ... 1 NIHR Bristol Biomedical Research Cent... 1 Nutrition and Cancer Group Epidemiolo... 1 Princess Margaret Cancer Centre Temer... 1 Prosserman Centre for Population Heal... 1 Reference Center for Epidemiology and... 1 School of Medicine Dentistry and Nurs... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Vlastník
-
Kusters, Johannes M A
Autor Kusters, Johannes M A ORCID Centre for Infectious Diseases Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands Institute for Infection and Immunity (AII), Amsterdam UMC, Amsterdam, The Netherlands Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
- Diergaarde, Brenda
- Ness, Andrew
- Schim van der Loeff, Maarten F
- Heijne, Janneke C M
- Schroeder, Lea
- Hueniken, Katrina
- McKay, James D
- Macfarlane, Gary J
- Lagiou, Pagona
PubMed
37694289
DOI
10.1002/ijc.34710
Knihovny.cz E-zdroje
A growing proportion of head and neck cancer (HNC), especially oropharyngeal cancer (OPC), is caused by human papillomavirus (HPV). There are several markers for HPV-driven HNC, one being HPV early antigen serology. We aimed to investigate the diagnostic accuracy of HPV serology and its performance across patient characteristics. Data from the VOYAGER consortium was used, which comprises five studies on HNC from North America and Europe. Diagnostic accuracy, that is, sensitivity, specificity, Cohen's kappa and correctly classified proportions of HPV16 E6 serology, was assessed for OPC and other HNC using p16INK4a immunohistochemistry (p16), HPV in situ hybridization (ISH) and HPV PCR as reference methods. Stratified analyses were performed for variables including age, sex, smoking and alcohol use, to test the robustness of diagnostic accuracy. A risk-factor analysis based on serology was conducted, comparing HPV-driven to non-HPV-driven OPC. Overall, HPV serology had a sensitivity of 86.8% (95% CI 85.1-88.3) and specificity of 91.2% (95% CI 88.6-93.4) for HPV-driven OPC using p16 as a reference method. In stratified analyses, diagnostic accuracy remained consistent across sex and different age groups. Sensitivity was lower for heavy smokers (77.7%), OPC without lymph node involvement (74.4%) and the ARCAGE study (66.7%), while specificity decreased for cases with <10 pack-years (72.1%). The risk-factor model included study, year of diagnosis, age, sex, BMI, alcohol use, pack-years, TNM-T and TNM-N stage. HPV serology is a robust biomarker for HPV-driven OPC, and its diagnostic accuracy is independent of age and sex. Future research is suggested on the influence of smoking on HPV antibody levels.
- MeSH
- infekce papilomavirem * MeSH
- lidé MeSH
- lidské papilomaviry MeSH
- lidský papilomavirus 16 MeSH
- nádory hlavy a krku * diagnóza MeSH
- nádory orofaryngu * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Sdílet
Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.