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Autor
Adams, Mark 1 Adolfsson, Rolf 1 Agartz, Ingrid 1 Agerbo, Esben 1 Air, Tracy M 1 Alda, Martin 1 Alfredsson, Lars 1 Andreassen, Ole A 1 Anjorin, Adebayo 1 Appadurai, Vivek 1 Ashley-Koch, Allison E 1 Awasthi, Swapnil 1 Azevedo, M Helena 1 Bass, Nicholas 1 Bau, Claiton H D 1 Baune, Bernhard T 1 Beckham, Jean C 1 Bellivier, Frank 1 Bergen, Andrew W 1 Berger, Klaus 1
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ADHD Outpatient Program Adult Divisio... 1 Analytical and Translational Genetics... 1 BESE Division King Abdullah Universit... 1 Behavioral Health Services Kaiser Per... 1 BioRealm LLC Walnut California 1 Biochemistry and Molecular Biology In... 1 Biomedical Informatics University of ... 1 Biomedical Network Research Centre on... 1 Biometric Psychiatric Genetics Resear... 1 Biostatistics Research Center Herbert... 1 Cancer Epidemiology and Prevention Sk... 1 Center for Applied Genomics Children'... 1 Center for Behavioral Genomics Depart... 1 Center for Eating Disorders at Sheppa... 1 Center for Neonatal Screening Departm... 1 Center for Neuropsychiatric Research ... 1 Center for Research in Environmental ... 1 Center for Statistical Genetics and D... 1 Center of Mental Health Research Aust... 1 Centre for Addiction and Mental Healt... 1
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Autor
Adams, Mark 1 Adolfsson, Rolf 1 Agartz, Ingrid 1 Agerbo, Esben 1 Air, Tracy M 1 Alda, Martin 1 Alfredsson, Lars 1 Andreassen, Ole A 1 Anjorin, Adebayo 1 Appadurai, Vivek 1 Ashley-Koch, Allison E 1 Awasthi, Swapnil 1 Azevedo, M Helena 1 Bass, Nicholas 1 Bau, Claiton H D 1 Baune, Bernhard T 1 Beckham, Jean C 1 Bellivier, Frank 1 Bergen, Andrew W 1 Berger, Klaus 1
- Organizace
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Pracoviště
ADHD Outpatient Program Adult Divisio... 1 Analytical and Translational Genetics... 1 BESE Division King Abdullah Universit... 1 Behavioral Health Services Kaiser Per... 1 BioRealm LLC Walnut California 1 Biochemistry and Molecular Biology In... 1 Biomedical Informatics University of ... 1 Biomedical Network Research Centre on... 1 Biometric Psychiatric Genetics Resear... 1 Biostatistics Research Center Herbert... 1 Cancer Epidemiology and Prevention Sk... 1 Center for Applied Genomics Children'... 1 Center for Behavioral Genomics Depart... 1 Center for Eating Disorders at Sheppa... 1 Center for Neonatal Screening Departm... 1 Center for Neuropsychiatric Research ... 1 Center for Research in Environmental ... 1 Center for Statistical Genetics and D... 1 Center of Mental Health Research Aust... 1 Centre for Addiction and Mental Healt... 1
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- Mullins, Niamh
- Kang, JooEun
- Campos, Adrian I
- Coleman, Jonathan R I
- Edwards, Alexis C
- Galfalvy, Hanga
- Levey, Daniel F
- Lori, Adriana
- Shabalin, Andrey
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Starnawska, Anna
Autor Starnawska, Anna Centre for Genomics and Personalized Medicine, Aarhus University, Aarhus, Denmark Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark Department of Biomedicine, Aarhus University, Aarhus, Denmark Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark
BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.
- MeSH
- celogenomová asociační studie MeSH
- depresivní porucha unipolární * genetika MeSH
- duševní poruchy * genetika MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- pokus o sebevraždu MeSH
- rizikové faktory MeSH
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- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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