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Autor
Attia, Tal Pal 1 Balzekas, Irena 1 Brinkmann, Benjamin H 1 Cimbalnik, Jan 1 Cook, Mark 1 Crepeau, Daniel 1 Crowe, Chelsea M 1 Denison, Timothy 1 Gregg, Nicholas M 1 Janca, Radek 1 Kim, Inyong 1 Kremen, Vaclav 1 Leyde, Kent 1 Lundstrom, Brian N 1 Marks, Victoria S 1 Miller, Kai J 1 Mivalt, Filip 1 Nejedly, Petr 1 Sladky, Vladimir 1 St Louis, Erik K 1
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Pracoviště
Cadence Neuroscience Seattle WA USA 1 Center for Sleep Medicine Departments... 1 Department of Bioengineering Oxford U... 1 Department of Neurologic Surgery Mayo... 1 Department of Neurology Bioelectronic... 1 Department of Neurology Royal Melbour... 1 Department of Veterinary Clinical Sci... 1 Faculty of Electrical Engineering Cze... 1 International Clinical Research Cente... 1
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Autor
Attia, Tal Pal 1 Balzekas, Irena 1 Brinkmann, Benjamin H 1 Cimbalnik, Jan 1 Cook, Mark 1 Crepeau, Daniel 1 Crowe, Chelsea M 1 Denison, Timothy 1 Gregg, Nicholas M 1 Janca, Radek 1 Kim, Inyong 1 Kremen, Vaclav 1 Leyde, Kent 1 Lundstrom, Brian N 1 Marks, Victoria S 1 Miller, Kai J 1 Mivalt, Filip 1 Nejedly, Petr 1 Sladky, Vladimir 1 St Louis, Erik K 1
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Pracoviště
Cadence Neuroscience Seattle WA USA 1 Center for Sleep Medicine Departments... 1 Department of Bioengineering Oxford U... 1 Department of Neurologic Surgery Mayo... 1 Department of Neurology Bioelectronic... 1 Department of Neurology Royal Melbour... 1 Department of Veterinary Clinical Sci... 1 Faculty of Electrical Engineering Cze... 1 International Clinical Research Cente... 1
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PubMed Central od 2019
Oxford Journals Open Access Collection od 2019-07-01
ROAD: Directory of Open Access Scholarly Resources od 2019
PubMed
35755635
DOI
10.1093/braincomms/fcac115
Knihovny.cz E-zdroje
Early implantable epilepsy therapy devices provided open-loop electrical stimulation without brain sensing, computing, or an interface for synchronized behavioural inputs from patients. Recent epilepsy stimulation devices provide brain sensing but have not yet developed analytics for accurately tracking and quantifying behaviour and seizures. Here we describe a distributed brain co-processor providing an intuitive bi-directional interface between patient, implanted neural stimulation and sensing device, and local and distributed computing resources. Automated analysis of continuous streaming electrophysiology is synchronized with patient reports using a handheld device and integrated with distributed cloud computing resources for quantifying seizures, interictal epileptiform spikes and patient symptoms during therapeutic electrical brain stimulation. The classification algorithms for interictal epileptiform spikes and seizures were developed and parameterized using long-term ambulatory data from nine humans and eight canines with epilepsy, and then implemented prospectively in out-of-sample testing in two pet canines and four humans with drug-resistant epilepsy living in their natural environments. Accurate seizure diaries are needed as the primary clinical outcome measure of epilepsy therapy and to guide brain-stimulation optimization. The brain co-processor system described here enables tracking interictal epileptiform spikes, seizures and correlation with patient behavioural reports. In the future, correlation of spikes and seizures with behaviour will allow more detailed investigation of the clinical impact of spikes and seizures on patients.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.