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Autor
Adami, Hans-Olov 1 Albanes, Demetrius 1 Anderson, Kenneth C 1 Ansell, Stephen M 1 Arias, Joshua 1 Bassig, Bryan 1 Becker, Nikolaus 1 Benavente, Yolanda 1 Berndt, Sonja I 1 Besson, Caroline 1 Bhatti, Parveen 1 Birmann, Brenda M 1 Boffetta, Paolo 1 Bracci, Paige M 1 Breeze, Charles 1 Brennan, Paul 1 Brooks-Wilson, Angela R 1 Brown, Elizabeth E 1 Burdett, Laurie 1 Camp, Nicola J 1
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Pracoviště
Bill Lyons Informatics Centre UCL Can... 1 CIBER de Epidemiología y Salud Públic... 1 CIRI Centre International de Recherch... 1 CPO Piemonte and Unit of Medical Stat... 1 CRESS UMR1153 INSERM Villejuif France 1 Cancer Control Research BC Cancer Age... 1 Cancer Epidemiology Division Cancer C... 1 Cancer Epidemiology Program Universit... 1 Cancer Epidemiology Research Programm... 1 Cancer Epidemiology Unit University o... 1 Cancer Genomics Research Laboratory D... 1 Cancer Prevention Institute of Califo... 1 Carolina Center for Genome Sciences U... 1 Center for Cancer Research National C... 1 Center for Health Sciences Exponent I... 1 Centre Henri Becquerel Université de ... 1 Centre Hospitalier de Versailles Le C... 1 Centre for Epidemiology and Biostatis... 1 Centre for Occupational and Environme... 1 Channing Division of Network Medicine... 1
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Autor
Adami, Hans-Olov 1 Albanes, Demetrius 1 Anderson, Kenneth C 1 Ansell, Stephen M 1 Arias, Joshua 1 Bassig, Bryan 1 Becker, Nikolaus 1 Benavente, Yolanda 1 Berndt, Sonja I 1 Besson, Caroline 1 Bhatti, Parveen 1 Birmann, Brenda M 1 Boffetta, Paolo 1 Bracci, Paige M 1 Breeze, Charles 1 Brennan, Paul 1 Brooks-Wilson, Angela R 1 Brown, Elizabeth E 1 Burdett, Laurie 1 Camp, Nicola J 1
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Pracoviště
Bill Lyons Informatics Centre UCL Can... 1 CIBER de Epidemiología y Salud Públic... 1 CIRI Centre International de Recherch... 1 CPO Piemonte and Unit of Medical Stat... 1 CRESS UMR1153 INSERM Villejuif France 1 Cancer Control Research BC Cancer Age... 1 Cancer Epidemiology Division Cancer C... 1 Cancer Epidemiology Program Universit... 1 Cancer Epidemiology Research Programm... 1 Cancer Epidemiology Unit University o... 1 Cancer Genomics Research Laboratory D... 1 Cancer Prevention Institute of Califo... 1 Carolina Center for Genome Sciences U... 1 Center for Cancer Research National C... 1 Center for Health Sciences Exponent I... 1 Centre Henri Becquerel Université de ... 1 Centre Hospitalier de Versailles Le C... 1 Centre for Epidemiology and Biostatis... 1 Centre for Occupational and Environme... 1 Channing Division of Network Medicine... 1
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- Berndt, Sonja I
- Vijai, Joseph
- Benavente, Yolanda
- Camp, Nicola J
- Nieters, Alexandra
- Wang, Zhaoming
- Smedby, Karin E
- Kleinstern, Geffen
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Hjalgrim, Henrik
Autor Hjalgrim, Henrik ORCID Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark Department of Haematology, Rigshospitalet, Copenhagen, Denmark Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark
- Besson, Caroline
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Nursing & Allied Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
36273105
DOI
10.1038/s41375-022-01711-0
Knihovny.cz E-zdroje
Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10-8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10-9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10-8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.
- MeSH
- celogenomová asociační studie MeSH
- genetická predispozice k nemoci * MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- nehodgkinský lymfom * genetika MeSH
- rizikové faktory MeSH
- studie případů a kontrol MeSH
- zárodečné buňky MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
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