Over a century ago, hyperplasia and hypertrophy of astrocytes was noted as a histopathological hallmark of multiple sclerosis and was hypothesized to play an important role in the development and course of this disease. However until today, the factual contribution of astrocytes to multiple sclerosis is elusive. Astrocytes may play an active role during degeneration and demyelination by controlling local inflammation in the CNS, provoking damage of oligodendrocytes and axons, and glial scarring but might also be beneficial by creating a permissive environment for remyelination and oligodendrocyte precursor migration, proliferation, and differentiation. Recent findings from our lab suggest that brain lipid binding protein (FABP7) is implicated in the course of multiple sclerosis and the regulation of astrocyte function. The relevance of our findings and data from other groups are highlighted and discussed in this paper in the context of myelin repair.
- MeSH
- astrocyty cytologie fyziologie chemie MeSH
- axony fyziologie patologie MeSH
- centrální nervový systém patofyziologie patologie MeSH
- demyelinizační nemoci diagnóza etiologie patologie MeSH
- fyziologie buňky fyziologie MeSH
- lidé MeSH
- metaanalýza jako téma MeSH
- myelinové proteiny chemie metabolismus MeSH
- myši MeSH
- nádorové supresorové proteiny fyziologie chemie MeSH
- oligodendroglie cytologie fyziologie patologie MeSH
- poranění mozku patofyziologie patologie MeSH
- regenerace fyziologie imunologie MeSH
- roztroušená skleróza etiologie patofyziologie patologie MeSH
- transportní proteiny fyziologie chemie MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- Publikační typ
- přehledy MeSH
