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Dental Unite Department of Surgery Az... 1 Department of Biomedical Science Univ... 1 Department of Chemistry and Pharmacy ... 1 Department of Clinical and Translatio... 1 Department of Periodontology School o... 1 Faculty of Medicine Charles Universit... 1 Faculty of Pharmacy Charles Universit... 1 Institute of Experimental Botany Czec... 1 National Research Council Institute o... 1 National Research Council Institute o... 1 Surgery and Experimental Science Depa... 1
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Dental Unite Department of Surgery Az... 1 Department of Biomedical Science Univ... 1 Department of Chemistry and Pharmacy ... 1 Department of Clinical and Translatio... 1 Department of Periodontology School o... 1 Faculty of Medicine Charles Universit... 1 Faculty of Pharmacy Charles Universit... 1 Institute of Experimental Botany Czec... 1 National Research Council Institute o... 1 National Research Council Institute o... 1 Surgery and Experimental Science Depa... 1
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PubMed Central od 2012
Europe PubMed Central od 2012
ProQuest Central od 2012-01-01
Open Access Digital Library od 2012-01-01
Open Access Digital Library od 2012-01-01
ROAD: Directory of Open Access Scholarly Resources od 2012
PubMed
32466371
DOI
10.3390/antibiotics9060281
Knihovny.cz E-zdroje
BACKGROUND: Given the increasing request for natural pharmacological molecules, this study assessed the antimicrobial capacity of Pistacia lentiscus L. essential oil (PLL-EO) obtained from the leaves of wild plants growing in North Sardinia (Italy) toward a wide range of periodontal bacteria and Candida, including laboratory and clinical isolates sp., together with its anti-inflammatory activity and safety. METHODS: PLL-EO was screened by gas chromatography/mass spectrometry. The minimal inhibitory concentration (MIC) was determined. The anti-inflammatory activity was measured by cyclooxygenase (COX-1/2) and lipoxygenase (LOX) inhibition, while the antioxidant capacity was determined electro-chemically and by the MTT assay. The WST-1 assay was used to ascertain cytotoxicity toward four lines of oral cells. RESULTS: According to the concentrations of terpens, PLL-EO is a pharmacologically-active phytocomplex. MICs against periodontal bacteria ranged between 3.13 and 12.5 µg/ml, while against Candida sp. they were between 6.25 and 12.5 µg/mL. Oxidation by COX-1/2 and LOX was inhibited by 80% and 20% µg/mL of the oil, respectively. Antioxidant activity seemed negligible, and no cytotoxicity arose. CONCLUSIONS: PLL-EO exhibits a broad-spectrum activity against periodontal bacteria and Candida, with an interesting dual inhibitory capacity toward COX-2 and LOX inflammatory enzymes, and without side effects against oral cells.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.