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Autor
Berchialla, Paola 1 Bolen, Christopher R 1 Chauvie, Stephane 1 Dalmasso, Federico 1 El-Galaly, Tarec Christoffer 1 Kinahan, Paul E 1 Kostakoglu, Lale 1 Lee, Calvin 1 Martelli, Maurizio 1 Mattiello, Federico 1 Nielsen, Tina G 1 Pierce, Larry A 1 Sahin, Deniz 1 Sehn, Laurie H 1 Trněný, Marek 1 Vitolo, Umberto 1
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Pracoviště
1st Faculty of Medicine Charles Unive... 1 BC Cancer Center for Lymphoid Cancer ... 1 Department of Clinical and Biological... 1 Department of Hematology Aalborg Univ... 1 Department of Radiology University of... 1 Department of Radiology and Medical I... 1 F Hoffmann La Roche Ltd Basel Switzer... 1 Genentech Inc South San Francisco Cal... 1 Hematology Department of Translationa... 1 Medical Physics Division Santa Croce ... 1 Multidisciplinary Oncology Outpatient... 1
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Autor
Berchialla, Paola 1 Bolen, Christopher R 1 Chauvie, Stephane 1 Dalmasso, Federico 1 El-Galaly, Tarec Christoffer 1 Kinahan, Paul E 1 Kostakoglu, Lale 1 Lee, Calvin 1 Martelli, Maurizio 1 Mattiello, Federico 1 Nielsen, Tina G 1 Pierce, Larry A 1 Sahin, Deniz 1 Sehn, Laurie H 1 Trněný, Marek 1 Vitolo, Umberto 1
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Pracoviště
1st Faculty of Medicine Charles Unive... 1 BC Cancer Center for Lymphoid Cancer ... 1 Department of Clinical and Biological... 1 Department of Hematology Aalborg Univ... 1 Department of Radiology University of... 1 Department of Radiology and Medical I... 1 F Hoffmann La Roche Ltd Basel Switzer... 1 Genentech Inc South San Francisco Cal... 1 Hematology Department of Translationa... 1 Medical Physics Division Santa Croce ... 1 Multidisciplinary Oncology Outpatient... 1
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NLK
Directory of Open Access Journals
od 2020
PubMed Central
od 2020
ProQuest Central
od 2021-02-01
Wiley-Blackwell Open Access Titles
od 2019
ROAD: Directory of Open Access Scholarly Resources
od 2020
PubMed
35846039
DOI
10.1002/jha2.421
Knihovny.cz E-zdroje
Image texture analysis (radiomics) uses radiographic images to quantify characteristics that may identify tumour heterogeneity and associated patient outcomes. Using fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT)-derived data, including quantitative metrics, image texture analysis and other clinical risk factors, we aimed to develop a prognostic model that predicts survival in patients with previously untreated diffuse large B-cell lymphoma (DLBCL) from GOYA (NCT01287741). Image texture features and clinical risk factors were combined into a random forest model and compared with the international prognostic index (IPI) for DLBCL based on progression-free survival (PFS) and overall survival (OS) predictions. Baseline FDG-PET scans were available for 1263 patients, 832 patients of these were cell-of-origin (COO)-evaluable. Patients were stratified by IPI or radiomics features plus clinical risk factors into low-, intermediate- and high-risk groups. The random forest model with COO subgroups identified a clearer high-risk population (45% 2-year PFS [95% confidence interval (CI) 40%-52%]; 65% 2-year OS [95% CI 59%-71%]) than the IPI (58% 2-year PFS [95% CI 50%-67%]; 69% 2-year OS [95% CI 62%-77%]). This study confirms that standard clinical risk factors can be combined with PET-derived image texture features to provide an improved prognostic model predicting survival in untreated DLBCL.
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