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Autor
Antunes, Sandra 1 Bello, Yamil 1 Diago, David 1 Domingos, Ana 1 Encinosa Guzmán, Pedro E 1 Erhart, Jan 1 Estrada, Mario Pablo 1 Frantova, Helena 1 Fuentes, Alier 1 Joglar, Marisdania 1 Kopacek, Petr 1 Ledesma Bravo, Frank L 1 Méndez, Luis 1 Perner, Jan 1 Rodríguez, Rafmary 1 Rodríguez-Mallon, Alina 1 Santos, Ana Sofia 1 Velez, Rita 1
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Autor
Antunes, Sandra 1 Bello, Yamil 1 Diago, David 1 Domingos, Ana 1 Encinosa Guzmán, Pedro E 1 Erhart, Jan 1 Estrada, Mario Pablo 1 Frantova, Helena 1 Fuentes, Alier 1 Joglar, Marisdania 1 Kopacek, Petr 1 Ledesma Bravo, Frank L 1 Méndez, Luis 1 Perner, Jan 1 Rodríguez, Rafmary 1 Rodríguez-Mallon, Alina 1 Santos, Ana Sofia 1 Velez, Rita 1
- Pracoviště
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NLK
Directory of Open Access Journals
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Free Medical Journals
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PubMed Central
od 2012
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ProQuest Central
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od 2012-01-01
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ROAD: Directory of Open Access Scholarly Resources
od 2012
PubMed
38003829
DOI
10.3390/pathogens12111365
Knihovny.cz E-zdroje
The control of ticks through vaccination offers a sustainable alternative to the use of chemicals that cause contamination and the selection of resistant tick strains. However, only a limited number of anti-tick vaccines have reached commercial realization. In this sense, an antigen effective against different tick species is a desirable target for developing such vaccines. A peptide derived from the tick P0 protein (pP0) conjugated to a carrier protein has been demonstrated to be effective against the Rhipicephalus microplus, Rhipicephalus sanguineus, and Amblyomma mixtum tick species. The aim of this work was to assess the efficacy of this peptide when conjugated to the Bm86 protein against Dermacentor nitens and Ixodes ricinus ticks. An RNAi experiment using P0 dsRNA from I. ricinus showed a dramatic reduction in the feeding of injected female ticks on guinea pigs. In the follow-up vaccination experiments, rabbits were immunized with the pP0-Bm86 conjugate and challenged simultaneously with larvae, nymphs, and the adults of I. ricinus ticks. In the same way, horses were immunized with the pP0-Bm86 conjugate and challenged with D. nitens larva. The pP0-Bm86 conjugate showed efficacies of 63% and 55% against I. ricinus and D. nitens ticks, respectively. These results, combined with previous reports of efficacy for this conjugate, show the promising potential for its development as a broad-spectrum anti-tick vaccine.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.