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Autor
Balaci, Alexandra J 1 Buechler, Connor R 1 Cawood, Ryan 1 Darrah, Patricia A 1 Dulcey, Andrés E 1 Esser-Kahn, Aaron P 1 Etrych, Tomas 1 Fisher, Kerry D 1 Francica, Joseph R 1 Gerner, Michael Y 1 Hills, Thomas 1 Ishizuka, Andrew S 1 Kastenmüller, Kathrin 1 Laga, Richard 1 Lynn, Geoffrey M 1 Pechar, Michal 1 Pola, Robert 1 Quinn, Kylie M 1 Ryu, Keun Ah 1 Seder, Robert A 1
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Pracoviště
Biological Imaging Section Research T... 1 Department of Biochemistry Faculty of... 1 Department of Chemistry University of... 1 Department of Oncology University of ... 1 Department of Oncology University of ... 1 Imaging Probe Development Center Nati... 1 Institute of Macromolecular Chemistry... 1 Lymphocyte Biology Section Laboratory... 1 Vaccine Research Center National Inst... 1 Vaccine Research Center National Inst... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
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Autor
Balaci, Alexandra J 1 Buechler, Connor R 1 Cawood, Ryan 1 Darrah, Patricia A 1 Dulcey, Andrés E 1 Esser-Kahn, Aaron P 1 Etrych, Tomas 1 Fisher, Kerry D 1 Francica, Joseph R 1 Gerner, Michael Y 1 Hills, Thomas 1 Ishizuka, Andrew S 1 Kastenmüller, Kathrin 1 Laga, Richard 1 Lynn, Geoffrey M 1 Pechar, Michal 1 Pola, Robert 1 Quinn, Kylie M 1 Ryu, Keun Ah 1 Seder, Robert A 1
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Pracoviště
Biological Imaging Section Research T... 1 Department of Biochemistry Faculty of... 1 Department of Chemistry University of... 1 Department of Oncology University of ... 1 Department of Oncology University of ... 1 Imaging Probe Development Center Nati... 1 Institute of Macromolecular Chemistry... 1 Lymphocyte Biology Section Laboratory... 1 Vaccine Research Center National Inst... 1 Vaccine Research Center National Inst... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
Medline Complete (EBSCOhost) od 1998-11-01 do 2015-11-30
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem
PubMed
26501954
DOI
10.1038/nbt.3371
Knihovny.cz E-zdroje
The efficacy of vaccine adjuvants such as Toll-like receptor agonists (TLRa) can be improved through formulation and delivery approaches. Here, we attached small molecule TLR-7/8a to polymer scaffolds (polymer-TLR-7/8a) and evaluated how different physicochemical properties of the TLR-7/8a and polymer carrier influenced the location, magnitude and duration of innate immune activation in vivo. Particle formation by polymer-TLR-7/8a was the most important factor for restricting adjuvant distribution and prolonging activity in draining lymph nodes. The improved pharmacokinetic profile by particulate polymer-TLR-7/8a was also associated with reduced morbidity and enhanced vaccine immunogenicity for inducing antibodies and T cell immunity. We extended these findings to the development of a modular approach in which protein antigens are site-specifically linked to temperature-responsive polymer-TLR-7/8a adjuvants that self-assemble into immunogenic particles at physiologic temperatures in vivo. Our findings provide a chemical and structural basis for optimizing adjuvant design to elicit broad-based antibody and T cell responses with protein antigens.
- MeSH
- adjuvancia imunologická chemie MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- nosiče léků chemie MeSH
- T-lymfocyty imunologie MeSH
- toll-like receptory agonisté MeSH
- vakcíny imunologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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