- Autor
-
Pracoviště
Canada Excellence Research Chair on t... 1 Central Nervous System Diseases Resea... 1 Department of Biomedical and Biotechn... 1 Department of Pharmacology Faculty of... 1 Endocannabinoid Research Group Instit... 1 Faculty of Bioscience and Technology ... 1 Scientific Core Unit Neuroimaging Max... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
- Autor
-
Pracoviště
Canada Excellence Research Chair on t... 1 Central Nervous System Diseases Resea... 1 Department of Biomedical and Biotechn... 1 Department of Pharmacology Faculty of... 1 Endocannabinoid Research Group Instit... 1 Faculty of Bioscience and Technology ... 1 Scientific Core Unit Neuroimaging Max... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
- Stark, Tibor
- Iannotti, Fabio Arturo
- Di Martino, Serena
- Di Bartolomeo, Martina
- Ruda-Kucerova, Jana
- Piscitelli, Fabiana
- Wotjak, Carsten T
- D'Addario, Claudio
- Drago, Filippo
-
Di Marzo, Vincenzo
Autor Di Marzo, Vincenzo ORCID Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli, Italy Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health, Faculty of Medicine and Faculty of Agricultural and Food Sciences, Centre de Recherche de l'Institut de Cardiologie et Pneumologie de l'Université et Institut sur la Nutrition et les Aliments Fonctionnels, Centre NUTRISS, Université Laval, Quebec City, QC G1V 4G5, Canada
NLK
Directory of Open Access Journals
od 2011
PubMed Central
od 2011
Europe PubMed Central
od 2011
ProQuest Central
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Health & Medicine (ProQuest)
od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2011
PubMed
35053256
DOI
10.3390/biom12010108
Knihovny.cz E-zdroje
In agreement with the neurodevelopmental hypothesis of schizophrenia, prenatal exposure of Sprague-Dawley rats to the antimitotic agent methylazoxymethanol acetate (MAM) at gestational day 17 produces long-lasting behavioral alterations such as social withdrawal and cognitive impairment in adulthood, mimicking a schizophrenia-like phenotype. These abnormalities were preceded at neonatal age both by the delayed appearance of neonatal reflexes, an index of impaired brain maturation, and by higher 2-arachidonoylglycerol (2-AG) brain levels. Schizophrenia-like deficits were reversed by early treatment [from postnatal day (PND) 2 to PND 8] with the CB1 antagonist/inverse agonist AM251 (0.5 mg/kg/day). By contrast, early CB1 blockade affected the behavioral performance of control rats which was paralleled by enhanced 2-AG content in the prefrontal cortex (PFC). These results suggest that prenatal MAM insult leads to premorbid anomalies at neonatal age via altered tone of the endocannabinoid system, which may be considered as an early marker preceding the development of schizophrenia-like alterations in adulthood.
- MeSH
- krysa rodu rattus MeSH
- methylazoxymethanolacetát * MeSH
- modely nemocí na zvířatech MeSH
- potkani Sprague-Dawley MeSH
- receptor kanabinoidní CB1 MeSH
- schizofrenie * chemicky indukované farmakoterapie genetika MeSH
- těhotenství MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Sdílet
Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.