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1st Faculty of Medicine and General F... 1 Arthritis Research UK Centre for Gene... 1 Centre for Health Services Research S... 1 Department of Clinical Chemistry Eras... 1 Department of Epidemiology and Biosta... 1 Department of Paediatric Immunology U... 1 Department of Statistical Sciences Un... 1 Institute of Child Health Birmingham ... 1 Rheumatology Unit UCL Institute of Ch... 1 ] Arthritis Research UK Centre for Ge... 1 ] Rheumatology Unit UCL Institute of ... 1
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1st Faculty of Medicine and General F... 1 Arthritis Research UK Centre for Gene... 1 Centre for Health Services Research S... 1 Department of Clinical Chemistry Eras... 1 Department of Epidemiology and Biosta... 1 Department of Paediatric Immunology U... 1 Department of Statistical Sciences Un... 1 Institute of Child Health Birmingham ... 1 Rheumatology Unit UCL Institute of Ch... 1 ] Arthritis Research UK Centre for Ge... 1 ] Rheumatology Unit UCL Institute of ... 1
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Cobb, J
Autor Cobb, J ] Arthritis Research UK Centre for Genetics and Genomics, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK [2] NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
- Cule, E
- Moncrieffe, H
- Hinks, A
- Ursu, S
- Patrick, F
- Kassoumeri, L
- Flynn, E
- Bulatović, M
- Wulffraat, N
Open Access Digital Library od 2001-01-01
Medline Complete (EBSCOhost) od 2001-01-01 do 2015-12-31
Health & Medicine (ProQuest) od 2001-01-01 do Před 1 rokem
PubMed
24709693
DOI
10.1038/tpj.2014.3
Knihovny.cz E-zdroje
Clinical response to methotrexate (MTX) treatment for children with juvenile idiopathic arthritis (JIA) displays considerable heterogeneity. Currently, there are no reliable predictors to identify non-responders: earlier identification could lead to a targeted treatment. We genotyped 759 JIA cases from the UK, the Netherlands and Czech Republic. Clinical variables were measured at baseline and 6 months after start of the treatment. In Phase I analysis, samples were analysed for the association with MTX response using ordinal regression of ACR-pedi categories and linear regression of change in clinical variables, and identified 31 genetic regions (P<0.001). Phase II analysis increased SNP density in the most strongly associated regions, identifying 14 regions (P<1 × 10(-5)): three contain genes of particular biological interest (ZMIZ1, TGIF1 and CFTR). These data suggest a role for novel pathways in MTX response and further investigations within associated regions will help to reach our goal of predicting response to MTX in JIA.
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- dítě MeSH
- jednonukleotidový polymorfismus MeSH
- juvenilní artritida farmakoterapie genetika MeSH
- kohortové studie MeSH
- lidé MeSH
- methotrexát terapeutické užití MeSH
- předškolní dítě MeSH
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- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
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- časopisecké články MeSH
- práce podpořená grantem MeSH
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