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CONACyT Centro de Investigación en Ma... 1 Department of Biochemistry University... 1 Groningen Biomolecular Sciences and B... 1 Guangzhou Key Laboratory of Subtropic... 1 Institute for Comparative Genomics De... 1 Institute for Comparative Genomics De... 1 Institute of Parasitology Biology Cen... 1 Oncode Institute Hubrecht Institute K... 1
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CONACyT Centro de Investigación en Ma... 1 Department of Biochemistry University... 1 Groningen Biomolecular Sciences and B... 1 Guangzhou Key Laboratory of Subtropic... 1 Institute for Comparative Genomics De... 1 Institute for Comparative Genomics De... 1 Institute of Parasitology Biology Cen... 1 Oncode Institute Hubrecht Institute K... 1
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PubMed
34650064
DOI
10.1038/s41467-021-26077-2
Knihovny.cz E-zdroje
Cells replicate and segregate their DNA with precision. Previous studies showed that these regulated cell-cycle processes were present in the last eukaryotic common ancestor and that their core molecular parts are conserved across eukaryotes. However, some metamonad parasites have secondarily lost components of the DNA processing and segregation apparatuses. To clarify the evolutionary history of these systems in these unusual eukaryotes, we generated a genome assembly for the free-living metamonad Carpediemonas membranifera and carried out a comparative genomics analysis. Here, we show that parasitic and free-living metamonads harbor an incomplete set of proteins for processing and segregating DNA. Unexpectedly, Carpediemonas species are further streamlined, lacking the origin recognition complex, Cdc6 and most structural kinetochore subunits. Carpediemonas species are thus the first known eukaryotes that appear to lack this suite of conserved complexes, suggesting that they likely rely on yet-to-be-discovered or alternative mechanisms to carry out these fundamental processes.
- MeSH
- biologická evoluce * MeSH
- DNA metabolismus MeSH
- Eukaryota genetika MeSH
- eukaryotické buňky metabolismus MeSH
- genom * MeSH
- genomika * MeSH
- mikrobiologie MeSH
- paraziti genetika MeSH
- proteiny genetika metabolismus MeSH
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- časopisecké články MeSH
- práce podpořená grantem MeSH
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