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Autor
Alexanderson, Helene 1 Andersson, Helena 1 Ceribelli, Angela 1 Chinoy, Hector 1 Dastmalchi, Maryam 1 Espinosa-Ortega, Fabricio 1 Griger, Zoltan 1 Leonard, Dag 1 Lilleker, James B 1 Lodin, Karin 1 Lundberg, Ingrid E 1 Maurer, Britta 1 Mercado M, Vazquez-Del 1 Shinjo, Samuel Katsuyuki 1 Torres-Ruiz, Jiram 1 Vencovsky, Jiri 1
- Organizace
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Pracoviště
Department of Biomedical Sciences Hum... 1 Department of Gastroenterology Dermat... 1 Department of Immunology and Rheumato... 1 Department of Medical Sciences Sectio... 1 Department of Medicine Division of Rh... 1 Department of Rheumatology Oslo Unive... 1 Department of Rheumatology Salford Ro... 1 Department of Rheumatology and Immuno... 1 Division of Clinical Immunology Facul... 1 Division of Musculoskeletal and Derma... 1 Division of Rheumatology Faculdade de... 1 Division of Rheumatology and Clinical... 1 Institute of Rheumatology and Departm... 1 Manchester Centre for Clinical Neuros... 1 National Institute for Health Researc... 1 Universidad de Guadalajara Centro Uni... 1 Women's Health and Health Professiona... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Vlastník
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Autor
Alexanderson, Helene 1 Andersson, Helena 1 Ceribelli, Angela 1 Chinoy, Hector 1 Dastmalchi, Maryam 1 Espinosa-Ortega, Fabricio 1 Griger, Zoltan 1 Leonard, Dag 1 Lilleker, James B 1 Lodin, Karin 1 Lundberg, Ingrid E 1 Maurer, Britta 1 Mercado M, Vazquez-Del 1 Shinjo, Samuel Katsuyuki 1 Torres-Ruiz, Jiram 1 Vencovsky, Jiri 1
- Organizace
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Pracoviště
Department of Biomedical Sciences Hum... 1 Department of Gastroenterology Dermat... 1 Department of Immunology and Rheumato... 1 Department of Medical Sciences Sectio... 1 Department of Medicine Division of Rh... 1 Department of Rheumatology Oslo Unive... 1 Department of Rheumatology Salford Ro... 1 Department of Rheumatology and Immuno... 1 Division of Clinical Immunology Facul... 1 Division of Musculoskeletal and Derma... 1 Division of Rheumatology Faculdade de... 1 Division of Rheumatology and Clinical... 1 Institute of Rheumatology and Departm... 1 Manchester Centre for Clinical Neuros... 1 National Institute for Health Researc... 1 Universidad de Guadalajara Centro Uni... 1 Women's Health and Health Professiona... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Vlastník
- Lodin, Karin
- Espinosa-Ortega, Fabricio
- Dastmalchi, Maryam
- Vencovsky, Jiri
- Andersson, Helena
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Chinoy, Hector
Autor Chinoy, Hector National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, The University of Manchester, Manchester, United Kingdom Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, United Kingdom Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
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Lilleker, James B
Autor Lilleker, James B Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Salford, United Kingdom
- Shinjo, Samuel Katsuyuki
- Maurer, Britta
- Griger, Zoltan
AIM: To explore if patient global assessment (PGA) is associated with inflammation over time and if associations are explained by other measures of disease activity and function in patients with idiopathic inflammatory myopathies (IIM). METHODS: PGA and systemic inflammatory markers prospectively collected over five years were retrieved from the International MyoNet registry for 1200 patients with IIM. Associations between PGA, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and creatine kinase (CK) were analyzed using mixed models. Mediation analysis was used to test if the association between PGA and inflammatory markers during the first year of observation could be explained by measures of disease activity and function. RESULTS: PGA improved, and inflammatory markers decreased during the first year of observation. In the mixed models, high levels of inflammatory markers were associated with worse PGA in both men and women across time points during five years of observation. In men, but not in women, the association between elevated ESR, CRP and poorer PGA was explained by measures of function and disease activity. With a few exceptions, the association between improved PGA and reduced inflammatory markers was partially mediated by improvements in all measures of function and disease activity. CONCLUSION: Increased levels of systemic inflammation are associated with poorer PGA in patients with IIM. In addition to known benefits of lowered inflammation, these findings emphasize the need to reduce systemic inflammation to improve subjective health in patients with IIM. Furthermore, the results demonstrate the importance of incorporating PGA as an outcome measure in clinical practice and clinical trials.
- MeSH
- hodnocení výsledků zdravotní péče MeSH
- krevní sedimentace MeSH
- lidé MeSH
- longitudinální studie MeSH
- myozitida * komplikace MeSH
- zánět MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
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