The guidelines focus on the clinical managment of α-thalassaemia syndromes. Intended for professional public.

• MeSH
• alfa-talasemie MeSH
• chelátová terapie MeSH
• krevní transfuze MeSH
• management nemoci MeSH
• Publikační typ
• směrnice pro lékařskou praxi MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• hematologie a transfuzní lékařství
• genetika, lékařská genetika

The guidelines focus on nutrition and diet therapy in thalassaemia and pyruvate kinase deficiency. Intended for professional public.

• MeSH
• dietoterapie MeSH
• fyziologie výživy MeSH
• pyruvátkinasa nedostatek   MeSH
• talasemie dietoterapie   MeSH
• vrozené poruchy metabolismu pyruvátu dietoterapie   MeSH
• Publikační typ
• směrnice pro lékařskou praxi MeSH

• Konspekt
• Hygiena. Lidské zdraví
• NLK Obory
• nutriční terapie, dietoterapie a výživa
• hematologie a transfuzní lékařství

Guidelines that focus on thalassaemia management and basic treatment. Intended for professional public.

• MeSH
• chelátová terapie MeSH
• krevní transfuze MeSH
• management nemoci MeSH
• talasemie terapie   MeSH
• Publikační typ
• příručky MeSH
• směrnice pro lékařskou praxi MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• hematologie a transfuzní lékařství
• genetika, lékařská genetika

Guidelines that focus on thalassaemia management and basic treatment. Intended for professional public.

• MeSH
• chelátová terapie MeSH
• krevní transfuze MeSH
• management nemoci MeSH
• talasemie terapie   MeSH
• Publikační typ
• směrnice pro lékařskou praxi MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• hematologie a transfuzní lékařství
• genetika, lékařská genetika

• O autorovi
• Thalassaemia International Federation Autorita

Guidelines that focus on thalassaemia management and basic treatment. Intended for professional public.

• MeSH
• chelátová terapie MeSH
• krevní transfuze MeSH
• management nemoci MeSH
• talasemie MeSH
• Publikační typ
• směrnice pro lékařskou praxi MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• hematologie a transfuzní lékařství
• genetika, lékařská genetika

• O autorovi
• Thalassaemia International Federation Autorita

PURPOSE: This paper compares individual radiation therapy techniques used for prostate cancer and their benefits in clinical practice. METHODS: We retrospectively analyzed 921 patients with localized prostate tumors treated between 1997 and 2012. We divided the patients into four groups according to the selected treatment technique (conformal radiation therapy [3DCRT], intensity-modulated radiation therapy [IMRT], image-guided radiation therapy [IGRT], and volumetric-modulated arc therapy [VMAT]) and evaluated the incidence of acute and chronic gastrointestinal (GI) and genitourinary (GU) toxicity. RESULTS: The incidence of grade 2 or greater acute GU and GI toxicity was significantly higher among techniques other than IGRT (p˂0.001). We found the same results in the case of grade 3 or greater acute GU toxicity (p˂0.001). Grade 3 or higher acute GI toxicity occurred only in one patient treated by 3DCRT. Cumulative late GI toxicity of grade 2 or higher and grade 3 or higher was recorded over 3 years significantly more frequently among non-IGRT techniques as compared to IGRT (p˂0.001). As regards GU toxicity, we found significantly higher incidence only for grade 2 or higher (p˂0.001), not for grade 3 or higher. No occurrence of grade 4 toxicity was recorded. The greatest incidence of patients without acute and chronic GI/GU toxicity was recorded in connection with VMAT. CONCLUSION: IGRT demonstrated a pronounced reduction in acute and chronic GU and GI toxicity as compared to non-IGRT techniques in the treatment of localized prostate cancer.

• MeSH
• akutní nemoc MeSH
• chronická nemoc MeSH
• gastrointestinální trakt patofyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory prostaty komplikace   MeSH
• radioterapie řízená obrazem metody   MeSH
• retrospektivní studie MeSH
• senioři MeSH
• urogenitální systém patofyziologie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH

PURPOSE: Prolongation of radiotherapy worsens the results of treatment of head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to identify the prognostic factors most affected by the prolongation of treatment. METHODS: 184 patients with locally advanced HNSCC were treated with curative chemo-radiation using SIB-IMRT from 2008 to 2016 and the influence of radiotherapy time (RTT) in groups of patients according to prognostic factors was retrospectively evaluated. RESULTS: Median overall survival (OS) was 45 months, median disease-free survival (DFS) was 41 months and median local control (LC) was not reached (mean LRC 68 months). In the multivariate analysis the radiotherapy prolongation negatively affected the LC in stage IV patients, T3/T4, in neck nodes positive disease, in oropharyngeal and oral cavity cancers, after neoadjuvant chemotherapy and in men. The RTT effect on DFS was significant in stage IV patients, patients with neck nodes positive disease and oropharyngeal cancer. RTT prolongation decreased OS within the groups of stage IV and grade 3 tumours. CONCLUSION: Prolonged RTT was associated with worsened OS and LRC, especially in stage IV patients and/or neck node positive disease and/or oropharyngeal cancer and we recommend that these patients should be prioritized in treatment gap compensation in radical radiotherapy for locally advanced HNSCC.

• MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory hlavy a krku patologie   radioterapie   MeSH
• radioterapie s modulovanou intenzitou metody   MeSH
• retrospektivní studie MeSH
• riziko MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• staging nádorů MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH