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Země: Grenada

4 záznamů v Medvik Filtry

Článek

Predictors of left ventricular remodelling and failure in right ventricular pacing in the young

European heart journal. 2009 ; 30 (9) : 1097-1104.

Eur Heart J
Medvik
Zdroj

AIMS: To identify risk factors for left ventricular (LV) dysfunction in right ventricular (RV) pacing in the young. methods and results: Left ventricular function was evaluated in 82 paediatric patients with either non-surgical (n = 41) or surgical (n= 41) complete atrioventricular block who have been 100% RV paced for a mean period of 7.4 years. Left ventricular shortening fraction (SF) decreased from a median (range) of 39 (24-62)% prior to implantation to 32 (8-49)% at last follow-up (P < 0.05). Prevalence of a combination of LV dilatation (LV end-diastolic diameter >+2z-values) and dysfunction (SF < 0.26) was found to increase from 1.3% prior to pacemaker implantation to 13.4% (11/82 patients) at last follow-up (P = 0.01). Ten of these 11 patients had progressive LV remodelling and 8 of 11 were symptomatic. The only significant risk factor for the development of LV dilatation and dysfunction was the presence of epicardial RV free wall pacing (OR = 14.3, P < 0.001). Other pre-implantation demographic, diagnostic, and haemodynamic factors including block aetiology, pacing variables, and pacing duration did not show independent significance. CONCLUSION: Right ventricular pacing leads to pathologic LV remodelling in a significant proportion of paediatric patients. The major independent risk factor is the presence of epicardial RV free wall pacing, which should be avoided whenever possible.

MeSH
diastola fyziologie MeSH
dítě MeSH
dysfunkce levé srdeční komory etiologie chirurgie patofyziologie MeSH
hodnocení rizik MeSH
kardiostimulace umělá metody škodlivé účinky MeSH
kojenec MeSH
lidé MeSH
mladiství MeSH
mladý dospělý MeSH
novorozenec MeSH
předškolní dítě MeSH
remodelace komor fyziologie MeSH
srdeční blokáda chirurgie MeSH
výsledek terapie MeSH
Check Tag
dítě MeSH
kojenec MeSH
lidé MeSH
mladiství MeSH
mladý dospělý MeSH
mužské pohlaví MeSH
novorozenec MeSH
předškolní dítě MeSH
ženské pohlaví MeSH
Publikační typ
práce podpořená grantem MeSH

Článek

The identity of the transcription +1 position is crucial for changes in gene expression in response to amino acid starvation in Bacillus subtilis

Molecular microbiology. 2008 ; 69 (1) : 42-54.

Mol Microbiol
ISSN 0950-382X
Medvik
Zdroj

We identify here a pattern in the transcription start sites (+1A or +1G) of sigma(A)-dependent promoters of genes that are up-/downregulated in response to amino acid starvation (stringent response) in Bacillus subtilis. Upregulated promoters initiate mostly with ATP and downregulated promoters with GTP. These promoters appear to be sensitive to changes in initiating nucleoside triphosphate concentrations. During the stringent response in B. subtilis, when ATP and GTP levels change reciprocally, the identity of the +1 position (A or G) of these promoters is a factor important in their regulation. Mutations that change the identity of position +1 (A for G and vice versa) change the response of the promoter to amino acid starvation.