- MeSH
- dospělí MeSH
- halucinogeny otrava MeSH
- kardiopulmonální resuscitace metody MeSH
- lidé MeSH
- methoxydimethyltryptaminy * otrava MeSH
- péče o pacienty v kritickém stavu MeSH
- poruchy spojené s užíváním psychoaktivních látek komplikace MeSH
- ropuchy * MeSH
- urgentní zdravotnické služby MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
BACKGROUND: 5-methoxy-N,N-dimethyltryptamine (hereinafter referred to as 5-MeO-DMT) is a psychedelic substance found in the secretion from the parotoid glands of the Bufo alvarius toad. Inhalation of vapor from toad secretion containing 5-MeO-DMT has become popular in naturalistic settings as a treatment of mental health problems or as a means for spiritual exploration. However, knowledge of the effects of 5-MeO-DMT in humans is limited. AIMS: The first objective of this study was to assess sub-acute and long-term effects of inhaling vapor from dried toad secretion containing 5-MeO-DMT on affect and cognition. The second objective was to assess whether any changes were associated with the psychedelic experience. METHODS: Assessments at baseline, within 24 h and 4 weeks following intake, were made in 42 individuals who inhaled vapor from dried toad secretion at several European locations. RESULTS: Relative to baseline, ratings of satisfaction with life and convergent thinking significantly increased right after intake and were maintained at follow-up 4 weeks later. Ratings of mindfulness also increased over time and reached statistical significance at 4 weeks. Ratings of depression, anxiety, and stress decreased after the session, and reached significance at 4 weeks. Participants that experienced high levels of ego dissolution or oceanic boundlessness during the session displayed higher ratings of satisfaction with life and lower ratings of depression and stress. CONCLUSION: A single inhalation of vapor from dried toad secretion containing 5-MeO-DMT produces sub-acute and long-term changes in affect and cognition in volunteers. These results warrant exploratory research into therapeutic applications of 5-MeO-DMT.
- MeSH
- aplikace inhalační MeSH
- dospělí MeSH
- duševní poruchy farmakoterapie epidemiologie psychologie MeSH
- halucinogeny aplikace a dávkování MeSH
- kognice účinky léků fyziologie MeSH
- lidé MeSH
- methoxydimethyltryptaminy aplikace a dávkování MeSH
- následné studie MeSH
- osobní uspokojení * MeSH
- ropuchy MeSH
- vaping psychologie MeSH
- všímavost metody MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
5-Methoxy-N,N-dimethyltryptamine (acronymized as 5-MeO-DMT) is sui generis among the numerous naturally occurring psychoactive substances due to its unparalleled ego-dissolving effects which can culminate in a state of nondual consciousness that is phenomenologically similar to transformative peak experiences described in various ancient contemplative traditions (e.g., Advaita Vedānta, Mahāyāna Buddhism, inter alia). The enigmatic molecule is endogenous to the human brain and has profound psychological effects which are hitherto only very poorly understood due to the absence of scientifically controlled human experimental trials. Its exact neuronal receptor binding profile is a matter of ongoing research; however, empirical evidence indicates that its remarkable psychoactivity is partially mediated via agonism of the 5-HT1A/2A (serotonin) receptor subtypes. Anthropological/ethnopharmacological evidence indicates that various cultures utilized 5-MeO-DMT containing plants for medicinal, psychological, and spiritual purposes for millennia. We propose that this naturally occurring serotonergic compound could be fruitfully utilized as a neurochemical research tool with the potential to significantly advance our understanding of the psychological and neuronal processes which underpin cognition and creativity (e.g., downregulation of the default mode network, increased global functional connectivity, neuroplasticity, σ1 receptor interactions, etc.). An eclectic interdisciplinary perspective is adopted, and we present converging evidence from a plurality of sources in support of our conjecture. Specifically, we argue that 5-MeO-DMT has significant neuropsychopharmacological potential due to its incommensurable capacity to completely disintegrate self-referential cognitive/neuronal processes (viz., ego death). The importance of unbiased systematic scientific research on naturally occurring endogenous psychoactive compounds is discussed from a Jamesian radical empiricism perspective, and potential scenarios of abuse are addressed, particularly in the context of neuroethics, cybernetic manipulation, and military research on torture.
Ayahuasca is a drink made from two plants native to the Amazon, Banisteriopsis caapi and Psychotria viridis, which contain the psychoactive chemicals: harmala alkaloids and dimethyltryptamine (DMT). The drink has long been used by aboriginal populations for its putative spiritual and medicinal benefits in countries such as Brazil, Ecuador and Peru. In the 20th century, ayahuasca spread beyond its native habitat and has been incorporated into syncretistic practices that are being adopted by non-indigenous peoples in modern Western contexts. Ayahuasca‘s globalization in the past few decades has led to a number of legal cases which pit religious freedom against national drug control laws. Two principal constituents of ayahuasca are harmala alkaloids and DMT. These compounds, when ingested in combination, produce a unique biochemical synergy resulting in profound idiosyncratic psychoactive effects. Harmala alkaloids are controlled substances in some countries and DMT is prohibited by international drug control conventions. Therefore relatively little is known about therapeutic use of ayahuasca. This article provides an overview of ayahuasca and explores some of the medical and philosophical implications of contemporary ayahuasca use.
- Klíčová slova
- ayahuasca, globalizace, tradiční místní znalosti, využití v medicíně, harmalové alkaloidy,
- MeSH
- Banisteriopsis chemie MeSH
- halucinace MeSH
- halucinogeny farmakokinetika farmakologie MeSH
- kardiovaskulární systém účinky léků MeSH
- LD50 MeSH
- lidé MeSH
- modely u zvířat MeSH
- N,N-dimethyltryptamin MeSH
- rostlinné extrakty farmakokinetika farmakologie MeSH
- serotonin MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- Amanita chemie MeSH
- atropin farmakokinetika farmakologie izolace a purifikace MeSH
- halucinogeny farmakokinetika farmakologie chemie MeSH
- houby chemie MeSH
- indolové alkaloidy farmakologie izolace a purifikace MeSH
- isoxazoly farmakokinetika farmakologie izolace a purifikace MeSH
- kyselina ibotenová farmakokinetika farmakologie izolace a purifikace MeSH
- lidé MeSH
- muscimol farmakokinetika farmakologie izolace a purifikace MeSH
- N,N-dimethyltryptamin farmakokinetika farmakologie izolace a purifikace MeSH
- psilocybin farmakokinetika farmakologie izolace a purifikace MeSH
- rostlinné přípravky farmakokinetika farmakologie izolace a purifikace MeSH
- skopolamin farmakokinetika farmakologie izolace a purifikace MeSH
- Solanaceae chemie MeSH
- tropany farmakokinetika farmakologie izolace a purifikace MeSH
- Check Tag
- lidé MeSH
- MeSH
- bufotenin farmakologie MeSH
- centrální nervový systém MeSH
- halucinogeny * farmakologie klasifikace MeSH
- ibogain farmakologie MeSH
- jedy obojživelníků MeSH
- lidé MeSH
- N,N-dimethyltryptamin MeSH
- otrava houbami MeSH
- poruchy spojené s užíváním psychoaktivních látek * MeSH
- psilocybin farmakologie MeSH
- schizofrenie MeSH
- soudní toxikologie zákonodárství a právo MeSH
- toxické psychózy MeSH
- toxikologie MeSH
- tryptaminy farmakologie MeSH
- Check Tag
- lidé MeSH
1. vyd. 364 s. : il. ; 20 cm
Tato kniha popisuje experimentální výzkum známého psychedelika. Naznačuje spoustu tendencí, které se snaží odpovědět, kdo jsme a proč tu jsme. Také se zamýšlí nad nebezpečím i očekáváním těch, kteří se rozhodli do sfér duše záměrně vztoupit.
- Klíčová slova
- psychedelika,
- MeSH
- epifýza mozková MeSH
- metafyzické vztahy mezi duší a tělem MeSH
- N,N-dimethyltryptamin MeSH
- psychofyziologie MeSH
- serotonin farmakologie MeSH
- výzkum MeSH
- Publikační typ
- eseje MeSH
- Konspekt
- Farmacie. Farmakologie
- NLK Obory
- psychofarmakologie
- adiktologie
- okultní vědy
