- MeSH
- almitrin aplikace a dávkování MeSH
- baroreflex fyziologie účinky léků MeSH
- experimenty na lidech MeSH
- hypoxie MeSH
- krevní oběh MeSH
- lidé MeSH
- měření krevního tlaku MeSH
- mladý dospělý MeSH
- senzitivita a specificita MeSH
- srdeční frekvence MeSH
- statistika jako téma MeSH
- Check Tag
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
To test whether the effect of almitrine on hypoxic pulmonary vasoconstriction was dose-dependent, two series of experiments were performed on isolated rat lungs perfused with constant flow of blood. In the first series, the effects of different doses of almitrine on perfusion pressure were measured. Baseline perfusion pressure was not changed by solvent or by 0.25 micrograms.ml-1 almitrine, but it was increased by 0.5 and 2.0 micrograms.ml-1 almitrine. The increase in perfusion pressure in response to 10 min ventilation with hypoxic gas mixture (5% O2) was significantly (p less than 0.05) higher after 0.25 micrograms.ml-1 almitrine (12.0 +/- 0.8 torr) than before addition of the drug (5.43 +/- 1.8 torr). Responses to hypoxia were insignificant after higher doses (0.5 and 2.0 micrograms.ml-1) of almitrine. In the second series of experiments the responses to varying degrees of hypoxia were measured after administration of one dose of almitrine (0.25 micrograms.ml-1). Almitrine, compared to solvent alone, significantly altered the shape of the dose-response curve to hypoxia. Increases in perfusion pressure in response to moderate degrees of hypoxia were potentiated (10% O2: 8.7 +/- 1.8 torr after almitrine, 2.1 +/- 0.6 torr after solvent, p less than 0.05), whereas responses to severe hypoxia (3% O2) were not changed by almitrine. Reactivity to angiotensin II was decreased by 0.25 micrograms.ml-1 almitrine. We conclude that almitrine in low but not in high dose augments pulmonary vasoconstriction induced by mild degrees of hypoxia.
- MeSH
- almitrin aplikace a dávkování farmakologie MeSH
- arteria pulmonalis * patofyziologie účinky léků MeSH
- hypoxie * patofyziologie MeSH
- inbrední kmeny potkanů MeSH
- krysa rodu rattus MeSH
- plíce * krevní zásobení patofyziologie MeSH
- vazokonstrikce * fyziologie účinky léků MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
Bulletin Européen de physiopathologie respiratoire, ISSN 0272-7587 vol. 23, suppl. 11, 1987
151s-216s s. : tab., grafy ; 30 cm
- Konspekt
- Farmacie. Farmakologie
- NLK Obory
- farmacie a farmakologie
- farmakoterapie
- pneumologie a ftizeologie
Revue des maladies respiratoires, ISSN 0761-8425 tome 2, suppl. 1, 1985
S1-S67 s. : tab. ; 30 cm
- MeSH
- almitrin MeSH
- obstrukční plicní nemoci terapie MeSH
- poměr plicní ventilace a perfuze fyziologie MeSH
- Publikační typ
- abstrakt z konference MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- pneumologie a ftizeologie
