V kazuistice prezentujeme případ patnáctiletého chlapce se vzácnou primární imunodeficiencí, tzv. syndromem XMEN. Tento syndrom je charakterizován zvýšenou náchylností k chronické EBV infekci a lymfoproliferacím asociovaným s EBV, dalšími klinickými znaky bývají sinopulmonární infekce, otitidy, lymfadenopatie, dysgamaglobulinemie a autoimunitní cytopenie. XMEN syndrom je způsoben mutacemi genu MAGT1, který kóduje přenašeč hořečnatých kationtů magnesium transporter protein 1. Klíčovým bodem kazuistiky je strastiplná diagnostická cesta pacienta, jemuž přes postupné návštěvy celé řady specialistů chybělo komplexní zhodnocení stavu a zachycení souvislostí různých klinických symptomů, které přinesla až návštěva v ambulanci alergologa/klinického imunologa
In this case report, we present a case of a 15 year old boy with a rare primary immunodeficiency called XMEN syndrome. XMEN syndrom is characterized by increased susceptibility to chronic EBV infection and EBV-associated lymphoproliferation, sinopulmonary and ear infections, lymphadenopathy, dysgammaglobulinemia, and autoimmune cytopenias. XMEN disease is caused by loss of function mutations in the gene MAGT1, which codes magnesium transporter protein 1.The critical point of the case report is the difficult diagnostic journey of the patient, who, despite a series of visits to several specialists, lacked a comprehensive assessment of his condition. A visit to an allergist/ clinical immunologist only gave a grasp of the context of various clinical symptoms.
Virové bradavice jsou celosvětově časté onemocnění způsobené lidským papilomavirem, který má řadu genotypů. Mnoho z těchto virů je komenzálních a u imunokompetentních hostitelů nevyvolávají žádné projevy. Za vhodných podmínek některé způsobují klinické změny na kůži nebo na sliznicích v anogenitální či orofaryngeální oblasti. U dětí se nejčastěji setkáváme s verruca vulgaris, verruca plantaris a verruca plana. Řada těchto projevů samovolně vymizí, problémem jsou perzistentní či úporně recidivující bradavice. Léčbou se snažíme nejen zlikvidovat viditelné změny za minimalizace bolesti a bez jizvení, ale také o prevenci recidivy ať již v místě původní bradavice nebo kdekoli jinde na těle.
Viral warts are a common disease worldwide caused by the human papillomavirus, which has a number of genotypes. Many of these viruses are commensal and do not cause any symptoms in immunocompetent hosts. Under appropriate conditions, however, some cause clinical changes on the skin or mucous membranes in the anogenital or oropharyngeal part. Verruca vulgaris, verruca plantaris and verruca plana are most often encountered in children. Many of these manifestations disappear on their own, the problem is persistent or stubbornly recurring warts. With the treatment, we try not only to eliminate visible changes while minimizing pain and without scarring, but also to prevent recurrence, whether at the site of the original wart or anywhere else on the body.
- MeSH
- Warts * drug therapy therapy MeSH
- Child * MeSH
- Fluorouracil pharmacology therapeutic use MeSH
- Papillomavirus Infections transmission therapy MeSH
- Keratinocytes pathology MeSH
- Cryotherapy methods MeSH
- Salicylic Acid therapeutic use MeSH
- Trichloroacetic Acid therapeutic use MeSH
- Lasers MeSH
- Humans MeSH
- Podophyllin pharmacology therapeutic use MeSH
- Check Tag
- Child * MeSH
- Humans MeSH
Virové bradavice jsou celosvětově časté onemocnění způsobené lidským papilomavirem, který má řadu genotypů. Mnoho z těchto virů je komenzálních a u imunokompetentních hostitelů nevyvolávají žádné projevy. Za vhodných podmínek některé způsobují klinické změny na kůži nebo na sliznicích v anogenitální či orofaryngeální oblasti. U dětí se nejčastěji setkáváme s verruca vulgaris, verruca plantaris a verruca plana. Řada těchto projevů samovolně vymizí, problémem jsou perzistentní či úporně recidivující bradavice. Léčbou se snažíme nejen zlikvidovat viditelné změny za minimalizace bolesti a bez jizvení, ale také o prevenci recidivy ať již v místě původní bradavice nebo kdekoli jinde na těle.
Viral warts are a common disease worldwide caused by the human papillomavirus, which has a number of genotypes. Many of these viruses are commensal and do not cause any symptoms in immunocompetent hosts. Under appropriate conditions, however, some cause clinical changes on the skin or mucous membranes in the anogenital or oropharyngeal part. Verruca vulgaris, verruca plantaris and verruca plana are most often encountered in children. Many of these manifestations disappear on their own, the problem is persistent or stubbornly recurring warts. With the treatment, we try not only to eliminate visible changes while minimizing pain and without scarring, but also to prevent recurrence, whether at the site of the original wart or anywhere else on the body.
- MeSH
- Warts * therapy MeSH
- Child * MeSH
- Immunotherapy methods MeSH
- Papillomavirus Infections drug therapy therapy MeSH
- Keratinocytes drug effects MeSH
- Cryotherapy methods MeSH
- Salicylic Acid pharmacology therapeutic use MeSH
- Lasers MeSH
- Humans MeSH
- Retinoids pharmacology therapeutic use MeSH
- Check Tag
- Child * MeSH
- Humans MeSH
OBJECTIVES: To evaluate the results of randomised controlled trials (RCTs) regarding the efficacy of human papillomavirus (HPV) vaccination in preventing male genital-related diseases. METHODS: A systematic search of English language literature using PubMed, Scopus, and Cochrane Library was performed in April 2024 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. RESULTS: Evidence from four RCTs (including 7008 male participants) support the efficacy of the quadrivalent HPV vaccine in preventing genital warts and persistent HPV infection in HPV-naïve men. The low incidence of male genital malignancies in the control groups of the reported studies lead to underpowered evidence. However, vaccination leads to durable protection with a long-term follow-up of 10 years showing efficacy of 91.8% to prevent HPV 6-, 11-, 16-, or 18-related external genital lesions (EGLs) in HPV-naïve subjects. Additionally, the quadrivalent vaccine seems to effectively reduce the detection of DNA from all four HPV types. CONCLUSION: In summary, early quadrivalent HPV vaccination demonstrates efficacy in preventing HPV infection and EGLs in males. Well controlled prospective studies are needed to confirm the long-term efficacy, specifically in cancer prevention, in all men and specific subject subgroups, and to identify the targeted population who is most likely to benefit from early vaccination.
- MeSH
- Papillomavirus Infections * prevention & control MeSH
- Condylomata Acuminata * prevention & control virology MeSH
- Humans MeSH
- Genital Diseases, Male * prevention & control virology MeSH
- Randomized Controlled Trials as Topic MeSH
- Papillomavirus Vaccines * administration & dosage MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Systematic Review MeSH
Bradavice jsou benigní útvary vyskytující se na kůži, méně často na sliznicích. Nejčastěji jsou jimi postiženy děti, adolescenti a imunosuprimovaní pacienti. Příčinou vzniku jsou viry patřící do skupiny humánních papillomavirů (HPV). Klinický obraz je variabilní. Bradavice mají značný sklon k recidivám. Rozlišujeme několik typů: vulgární bradavice - verrucae vulgares, plantární bradavice - verrucae plantares, ploché bradavice - verrucae planae juvenilis, střapcovité bradavice - verrucae filliformes a genitální bradavice - condylomata accuminata.
The warts are benign lesions, which occur on the skin, rarely on the mucosa. Children, adolescents, and people with diminished resistance are mostly infected. Human papillomavirus (HPV) is responsible for many lesions. The warts tend to relapse. We differentiate several types of warts - verrucae vulgares, verrucae plantares, verrucae planea juvenilis, verrucae filliformis, and condylomata accuminata.
- MeSH
- Warts * classification transmission therapy MeSH
- Humans MeSH
- Human Papillomavirus Viruses pathogenicity MeSH
- Primary Health Care MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
BACKGROUND: The aim of the study was to assess socio-demographical characteristics, clinical presentation, and outcomes in patients diagnosed with mpox. METHODS: A survey on patients diagnosed with mpox was performed in 14 countries from Central and Eastern Europe. Data was compared according to HIV status and country of origin (EU vs. non-EU). Mpox diagnosis was confirmed by RT-PCR from oropharyngeal swabs, skin lesions, and other body fluids. RESULTS: Out of 154 patients confirmed with mpox in 2022, 99.3% were males, with a median age (years) of 35 (IQR 30-39), 90.2% MSM and 48.7% PLWH. Compared to HIV-negative subjects, PLWH had more frequent high-risk behaviours:chemsex (p = 0.015), group sex (p = 0.027), and a history of sexually transmitted infections (STIs) (p = 0.004). Persons from EU were more often PLWH (p = 0.042), MSM (p < 0.0001), had multiple sexual partners (p = 0.025), practiced chemsex (p = 0.008) or group-sex (p = 0.005) and had more often history of STIs (p < 0.0001). The median CD4 cell count/mL at mpox diagnosis was 713 (IQR 486-996) and 73.5% had undetectable HIV VL. The commonest clinical features were fever (108 cases), lymphadenopathy (78), and vesiculo-pustular rash: penile (76), perianal (48), limbs (67). Fifty-one (31%) persons were hospitalized due to complications or epidemiological reasons. Three patients received tecovirimat or cidofovir. The outcome was favorable for all patients, including 4 with severe forms. CONCLUSIONS: Mpox was diagnosed predominantly in young MSM, with high-risk behaviors and history of STIs. Effective contact tracing and vaccination are important strategic pillars to control mpox outbreaks.
- MeSH
- Adult MeSH
- Disease Outbreaks * MeSH
- HIV Infections epidemiology MeSH
- Condylomata Acuminata epidemiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Sexually Transmitted Diseases epidemiology diagnosis MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Europe MeSH
- Europe, Eastern MeSH
- MeSH
- Dermatitis, Atopic classification pathology therapy MeSH
- Warts drug therapy classification therapy MeSH
- Child MeSH
- Impetigo drug therapy pathology MeSH
- Skin Diseases * classification pathology therapy MeSH
- Humans MeSH
- Molluscum Contagiosum pathology therapy MeSH
- Diaper Rash classification therapy MeSH
- Dermatitis, Seborrheic pathology therapy MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Review MeSH
Epidermodysplasia verruciformis je extrémně vzácné autozomálně recesivně dědičné kožní onemocnění se známými mutacemi v genech EVER1/TMC6 a EVER2/TMC8, nazývané také Lewandowského-Lutzův syndrom. Onemocnění je asociované s různými typy HPV virů, např. 5 a 8. V klinickém obraze, na místech ozářených sluncem, vznikají generalizované makuly až plaky připomínající kůru stromu, narůstající někdy do gigantických rozměrů. V níže uvedené kazuistice popisujeme případ mladého pacienta s anamnézou získané formy epidermodysplasia verruciformis při imunosupresi.
Epidermodysplasia verruciformis is an extremely rare autosomal recessive inherited skin disease, with known mutations in the EVER1/TMC6 and EVER2/TMC8 genes, also called Lewandowski-Lutz syndrome. The disease is associated with different types of HPV viruses, e.g. 5 and 8. In the clinical picture, generalized macules or plaques sometimes grow to gigantic dimensions, resembling the bark of a tree, in places exposed to the sun. In the case report below, we describe the case of a young patient with a history of acquired epidermodysplasia verruciformis during immunosuppression.
- MeSH
- Warts etiology pathology MeSH
- Adult MeSH
- Epidermodysplasia Verruciformis * diagnosis etiology pathology therapy MeSH
- Immunosuppression Therapy * methods adverse effects MeSH
- Humans MeSH
- Drug Substitution MeSH
- Tacrolimus adverse effects MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Fissure in Ano diagnosis etiology therapy MeSH
- Child MeSH
- Enterobiasis diagnosis drug therapy MeSH
- Hemorrhoids diagnosis drug therapy prevention & control MeSH
- Colorectal Surgery * classification methods MeSH
- Condylomata Acuminata diagnosis drug therapy classification microbiology MeSH
- Humans MeSH
- Pilonidal Sinus diagnosis classification MeSH
- Rectal Prolapse diagnosis drug therapy prevention & control MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Review MeSH
- MeSH
- Warts diagnosis transmission therapy MeSH
- Condylomata Acuminata diagnosis therapy MeSH
- Humans MeSH
- Molluscum Contagiosum diagnosis transmission therapy MeSH
- Skin Diseases, Viral * diagnosis transmission therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
