- MeSH
- Congresses as Topic MeSH
- Tobacco Smoking * adverse effects MeSH
- Humans MeSH
- Smoking Cessation MeSH
- Vaping * MeSH
- Check Tag
- Humans MeSH
- Publication type
- News MeSH
- MeSH
- Congresses as Topic MeSH
- Smoking Cessation methods MeSH
- Tobacco Use Cessation Devices classification MeSH
- Electronic Nicotine Delivery Systems classification statistics & numerical data MeSH
- Vaping * prevention & control adverse effects trends MeSH
- Publication type
- News MeSH
- Geographicals
- England MeSH
- MeSH
- Cigarette Smoking prevention & control therapy MeSH
- Humans MeSH
- Smoking Cessation methods MeSH
- Smoking Reduction * methods MeSH
- Secondary Prevention methods MeSH
- Harm Reduction MeSH
- Electronic Nicotine Delivery Systems MeSH
- Vaping * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Newspaper Article MeSH
- MeSH
- Congresses as Topic MeSH
- Tobacco Smoking adverse effects MeSH
- Humans MeSH
- Smoking Cessation * methods MeSH
- Electronic Nicotine Delivery Systems * MeSH
- Vaping MeSH
- Check Tag
- Humans MeSH
- Publication type
- Newspaper Article MeSH
- News MeSH
Elektronické cigarety a ich používanie známe aj pod pojmom vaping sa stali v poslednej dobe celosvetovým trendom a to najmä v populácii adolescentov a mladých dospelých. Napriek ich popularite však doposiaľ nie sú dostatočne preštudované a môžu predstavovať závažné riziko pre naše zdravie. EVALI (E-cigarette or vaping use-associated lung injury) je nedávno popísaný pojem, ktorý predstavuje poškodenie pľúc v dôsledku inhalácie látok obsiahnutých v e-cigaretách a v súčasnosti je predmetom viacerých výskumov. Ochorenie je sprevádzané širokou škálou symptómov, diagnostika je náročná a spočíva vo vylúčení iných príčin. Takisto pri liečbe neexistujú jednoznačné odporúčania, dobrá klinická odpoveď je na liečbu kortikoidmi. Tento prehľadový článok je doplnený o kazuistiku 17. ročného pacienta, ktorá poukazuje na to, že aj v našich podmienkach je možné sa s EVALI stretnúť a je potrebné po abúze e-cigariet najmä u pacientov v adolescentnom veku anamnesticky pátrať.
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- MeSH
- Humans MeSH
- Adolescent MeSH
- Lung Injury * diagnosis drug therapy therapy MeSH
- Electronic Nicotine Delivery Systems * MeSH
- Vaping pathology prevention & control adverse effects MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Smoking epidemiology adverse effects MeSH
- Smoking Cessation Agents therapeutic use MeSH
- Humans MeSH
- Nicotine Replacement Therapy MeSH
- Smoking Cessation * MeSH
- Tobacco Use Disorder therapy MeSH
- Electronic Nicotine Delivery Systems MeSH
- Tobacco Use Cessation MeSH
- Vaping MeSH
- Check Tag
- Humans MeSH
UNLABELLED: Tobacco use is a major modifiable risk factor for adverse health outcomes, including cancer, and elicits profound epigenetic changes thought to be associated with long-term cancer risk. While electronic cigarettes (e-cigarettes) have been advocated as harm reduction alternatives to tobacco products, recent studies have revealed potential detrimental effects, highlighting the urgent need for further research into the molecular and health impacts of e-cigarettes. Here, we applied computational deconvolution methods to dissect the cell- and tissue-specific epigenetic effects of tobacco or e-cigarette use on DNA methylation (DNAme) in over 3,500 buccal/saliva, cervical, or blood samples, spanning epithelial and immune cells at directly and indirectly exposed sites. The 535 identified smoking-related DNAme loci [cytosine-phosphate-guanine sites (CpG)] clustered into four functional groups, including detoxification or growth signaling, based on cell type and anatomic site. Loci hypermethylated in buccal epithelial cells of smokers associated with NOTCH1/RUNX3/growth factor receptor signaling also exhibited elevated methylation in cancer tissue and progressing lung carcinoma in situ lesions, and hypermethylation of these sites predicted lung cancer development in buccal samples collected from smokers up to 22 years prior to diagnosis, suggesting a potential role in driving carcinogenesis. Alarmingly, these CpGs were also hypermethylated in e-cigarette users with a limited smoking history. This study sheds light on the cell type-specific changes to the epigenetic landscape induced by smoking-related products. SIGNIFICANCE: The use of both cigarettes and e-cigarettes elicits cell- and exposure-specific epigenetic effects that are predictive of carcinogenesis, suggesting caution when broadly recommending e-cigarettes as aids for smoking cessation.
- MeSH
- Adult MeSH
- Epigenesis, Genetic * MeSH
- Carcinogenesis * genetics MeSH
- Cigarette Smoking * adverse effects genetics MeSH
- Humans MeSH
- DNA Methylation * MeSH
- Lung Neoplasms genetics etiology pathology MeSH
- Receptor, Notch1 genetics MeSH
- Electronic Nicotine Delivery Systems * MeSH
- Vaping adverse effects MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- MeSH
- Tobacco Smoking * adverse effects MeSH
- Humans MeSH
- Neoplasms * etiology MeSH
- Risk Factors MeSH
- Vaping MeSH
- Check Tag
- Humans MeSH
Over the past decade, there has been a significant rise in the use of vaping devices, particularly among adolescents, raising concerns for effects on respiratory health. Pressingly, many recent vaping-related lung injuries are unexplained by current knowledge, and the overall implications of vaping for respiratory health are poorly understood. This study investigates the effect of hydrophobic vaping liquid chemicals on the pulmonary surfactant biophysical function. We focus on the commonly used flavoring benzaldehyde and its vaping byproduct, benzaldehyde propylene glycol acetal. The study involves rigorous testing of the surfactant biophysical function in Langmuir trough and constrained sessile drop surfactometer experiments with both protein-free synthetic surfactant and hydrophobic protein-containing clinical surfactant models. The study reveals that exposure to these vaping chemicals significantly interferes with the synthetic and clinical surfactant biophysical function. Further atomistic simulations reveal preferential interactions with SP-B and SP-C surfactant proteins. Additionally, data show surfactant lipid-vaping chemical interactions and suggest significant transfer of vaping chemicals to the experimental subphase, indicating a toxicological mechanism for the alveolar epithelium. Our study, therefore, reveals novel mechanisms for the inhalational toxicity of vaping. This highlights the need to reassess the safety of vaping liquids for respiratory health, particularly the use of aldehyde chemicals as vaping flavorings.
