- Keywords
- xenoestrogeny,
- MeSH
- Estrogens physiology deficiency MeSH
- Humans MeSH
- Progesterone physiology deficiency MeSH
- Check Tag
- Humans MeSH
- MeSH
- Food Analysis MeSH
- Estrogens physiology MeSH
- Phytoestrogens * pharmacology classification MeSH
- Nutritional Physiological Phenomena MeSH
- Isoflavones administration & dosage MeSH
- Climacteric * physiology MeSH
- Humans MeSH
- Food classification MeSH
- Diet, Healthy MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Popular Work MeSH
- MeSH
- Estrogens physiology MeSH
- Hormones physiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Menopause * physiology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Newspaper Article MeSH
- Keywords
- studie WHIMS,
- MeSH
- Alzheimer Disease prevention & control MeSH
- Central Nervous System metabolism MeSH
- Dementia * epidemiology etiology prevention & control MeSH
- Estrogens * pharmacology physiology MeSH
- Hormone Replacement Therapy MeSH
- Cognition * MeSH
- Drug Therapy, Combination MeSH
- Middle Aged MeSH
- Humans MeSH
- Menopause MeSH
- Postmenopause MeSH
- Observational Studies as Topic MeSH
- Randomized Controlled Trials as Topic MeSH
- Risk Factors MeSH
- Aged MeSH
- Sex Factors MeSH
- Age Factors MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- MeSH
- Androgens MeSH
- Estrogen Replacement Therapy MeSH
- Estrogens * pharmacology physiology therapeutic use MeSH
- Breast Feeding MeSH
- Pregnancy Complications MeSH
- Bone and Bones * physiology physiopathology MeSH
- Bone Density physiology MeSH
- Humans MeSH
- Menopause MeSH
- Vitamin D Deficiency MeSH
- Bone Diseases etiology classification physiopathology pathology MeSH
- Osteoporosis etiology classification pathology MeSH
- Osteoporosis, Postmenopausal drug therapy prevention & control MeSH
- Calcium therapeutic use MeSH
- Age Factors MeSH
- Vitamin D MeSH
- Malpractice MeSH
- Check Tag
- Humans MeSH
- Female MeSH
BACKGROUND: The harmful effects of endocrine disrupting compounds (EDCs) on human health are generally well-known, and exposure during fetal development may have lasting effects. Fetal exposure to bisphenol A (BPA) has been recently relatively well-studied; however, less is known about alternatives such as bisphenol S (BPS), bisphenol F (BPF) and bisphenol AF (BPAF), which have started to appear in consumer products. Parabens are another widespread group of EDCs, with confirmed transplacental passage. The usage of many cosmetic, pharmaceutical and consumer products during the pregnancy that may contain parabens and bisphenols has led to the need for investigation. OBJECTIVES: To shed more light into the transplacental transport of BPA, its alternatives, and parabens, and to study their relation to fetal steroidogenesis. METHODS: BPA, BPS, BPF, BPAF, methylparaben, ethylparaben, propylparaben, butylparaben, benzylparaben and 15 steroids including estrogens, corticoids, androgens and immunomodulatory ones were determined in 27 maternal (37th week of pregnancy) and cord plasma samples using liquid chromatography - tandem mass spectrometry methods. RESULTS: In cord blood, significantly higher BPA levels (p=0.0455) were observed compared to maternal plasma. The results from multiple regression models showed that in cord blood, methylparaben (β=-0.027, p=0.027), propylparaben (β=-0.025, p=0.03) and the sum of all measured parabens (β=-0.037, p=0.015) were inversely associated with testosterone levels. CONCLUSION: To the best of our knowledge, this is the first study reporting the simultaneous detection of BPA, alternative bisphenols, parabens and steroids in maternal and cord plasma. Our study confirmed the transplacental transport of BPA, with likely accumulation in the fetal compartment. The negative association of cord blood parabens and testosterone levels points to possible risks with respect to importance of testosterone for prenatal male development.
- MeSH
- Benzhydryl Compounds pharmacokinetics pharmacology MeSH
- Chromatography, Liquid MeSH
- Adult MeSH
- Endocrine Disruptors * pharmacokinetics MeSH
- Estrogens physiology MeSH
- Phenols pharmacokinetics MeSH
- Fetal Blood * chemistry MeSH
- Humans MeSH
- Maternal Exposure MeSH
- Infant, Newborn MeSH
- Parabens * pharmacokinetics MeSH
- Pregnancy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- MeSH
- Estrogens physiology MeSH
- Clinical Studies as Topic MeSH
- Bone Density drug effects MeSH
- Humans MeSH
- Osteoporosis prevention & control MeSH
- Postmenopause * physiology drug effects MeSH
- Pregnancy MeSH
- Calcium * pharmacology metabolism therapeutic use MeSH
- Check Tag
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
