This study describes a one-pot synthesis of superparamagnetic maghemite-based 4-aminobenzoic acid-coated spherical core-shell nanoparticles (PABA@FeNPs) as suitable nanocomposites potentially usable as magnetic carriers for drug delivery. The PABA@FeNPs system was subsequently functionalized by the activated species (1* and 2*) of highly in vitro cytotoxic cis-[PtCl2(3Claza)2] (1; 3Claza stands for 3-chloro-7-azaindole) or cis-[PtCl2(5Braza)2] (2; 5Braza stands for 5-bromo-7-azaindole), which were prepared by a silver(I) ion assisted dechlorination of the parent dichlorido complexes. The products 1*@PABA@FeNPs and 2*@PABA@FeNPs, as well as an intermediate PABA@FeNPs, were characterized by a combination of various techniques, such as Mössbauer, FTIR and EDS spectroscopy, thermal analysis, SEM and TEM. The results showed that the products consist of well-dispersed maghemite-based nanoparticles of 13 nm average size that represent an easily obtainable system for delivery of highly cytotoxic cisplatin-like complexes in oncological practice.
- MeSH
- cisplatina aplikace a dávkování chemie MeSH
- indoly chemická syntéza chemie MeSH
- kyselina 4-aminobenzoová aplikace a dávkování chemická syntéza chemie MeSH
- lékové transportní systémy * MeSH
- lidé MeSH
- nádory farmakoterapie MeSH
- nanočástice chemie MeSH
- nosiče léků chemická syntéza chemie MeSH
- protinádorové látky chemie MeSH
- stříbro chemie MeSH
- železité sloučeniny chemická syntéza chemie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Klíčová slova
- POTABA,
- MeSH
- indurace penisu farmakoterapie patologie MeSH
- kyselina 4-aminobenzoová aplikace a dávkování farmakologie MeSH
- lidé MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
