• MeSH
• Fetomaternal Transfusion * diagnosis   drug therapy   classification   MeSH
• Case Reports as Topic MeSH
• Humans MeSH
• Infant, Newborn MeSH
• Placenta abnormalities   MeSH
• Check Tag
• Humans MeSH
• Infant, Newborn MeSH
• Female MeSH
• Publication type
• Review MeSH

Placentární mezenchymální dysplázie je vzácná jednotka charakterizovaná placentomegalií, cévními abnormalitami a tvorbou cystických útvarů v placentárním parenchymu. Tato léze může být asociována s různými genetickými abnormalitami, růstovou restrikcí plodu či nitroděložním odumřením plodu. Diferenciálně diagnosticky je důležité odlišit placentární mezenchymální dysplázii zejména od parciální hydatidózní moly. Cílem tohoto článku je poskytnout čtenářům základní přehled o morfologii a diferenciální diagnostice této patologické jednotky.

SUMMARY Placental mesenchymal dysplasia is a rare placental lesion characterized by placentomegaly, vascular abnormalities and formation of cystic structures in the placental parenchyma. It can be associated with various genetic abnormalities, fetal growth restriction or intrauterine fetal demise. Placental mesenchymal dysplasia needs to be distinguished from its main differential diagnosis, partial hydatidiform mole. The aim of this article is to provide readers with a basic overview of the morphology and differential diagnosis of this pathological entity.

• Keywords
• placentární mezenchymální dysplázie,
• MeSH
• Diagnosis, Differential MeSH
• Pregnancy Complications MeSH
• Humans MeSH
• Hydatidiform Mole * diagnosis   pathology   MeSH
• Placenta Diseases * diagnosis   pathology   MeSH
• Placenta abnormalities   anatomy & histology   pathology   MeSH
• Pregnancy MeSH
• Check Tag
• Humans MeSH
• Pregnancy MeSH
• Female MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

• MeSH
• Humans MeSH
• Placenta Diseases diagnostic imaging   epidemiology   MeSH
• Placenta Accreta mortality   surgery   MeSH
• Placenta abnormalities   MeSH
• Predictive Value of Tests MeSH
• Pregnancy MeSH
• Ultrasonography methods   standards   MeSH
• Check Tag
• Humans MeSH
• Pregnancy MeSH
• Female MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH
• Editorial MeSH

Interspecific hybridization between closely related mammalian species, including various species of the genus Mus, is commonly associated with abnormal growth of the placenta and hybrid foetuses, a phenomenon known as hybrid placental dysplasia (HPD). The role of HPD in speciation is anticipated but still poorly understood. Here, we studied placental and foetal growth in F1 crosses between four inbred mouse strains derived from two house mouse subspecies, Mus musculus musculus and Mus musculus domesticus. These subspecies are in the early stage of speciation and still hybridize in nature. In accordance with the maternal-foetal genomic conflict hypothesis, we found different parental influences on placental and foetal development, with placental weight most affected by the father's body weight and foetal weight by the mother's body weight. After removing the effects of parents' body weight, we did not find any significant differences in foetal or placental weights between intra-subspecific and inter-subspecific F1 crosses. Nevertheless, we found that the variability in placental weight in inter-subspecific crosses is linked to the X chromosome, similarly as for HPD in interspecific mouse crosses. Our results suggest that maternal-foetal genomic conflict occurs in the house mouse system, but has not yet diverged sufficiently to cause abnormalities in placental and foetal growth in inter-subspecific crosses. HPD is thus unlikely to contribute to speciation in the house mouse system. However, we cannot rule out that it might have contributed to other speciation events in the genus Mus, where differences in the levels of polyandry exist between the species.

• MeSH
• Chimera MeSH
• Genome MeSH
• Mice, Inbred Strains embryology   genetics   MeSH
• Crosses, Genetic MeSH
• Quantitative Trait Loci MeSH
• Mice, Inbred C57BL embryology   genetics   MeSH
• Mice MeSH
• Placenta abnormalities   pathology   MeSH
• Fetus MeSH
• Sex Ratio MeSH
• Pregnancy, Animal genetics   MeSH
• Pregnancy MeSH
• Body Weight MeSH
• Organ Size MeSH
• Litter Size MeSH
• Animals MeSH
• Check Tag
• Male MeSH
• Mice MeSH
• Pregnancy MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

• MeSH
• Twins, Monozygotic MeSH
• Pregnancy Complications pathology   MeSH
• Placenta abnormalities   MeSH
• Pregnancy, Multiple MeSH
• Abnormalities, Severe Teratoid embryology   pathology   MeSH

• Conspectus
• Lékařské vědy. Lékařství
• NML Fields
• patologie
• gynekologie a porodnictví
• perinatologie a neonatologie
• gynekologie a porodnictví

• MeSH
• Adult MeSH
• Placenta Accreta MeSH
• Placenta Previa MeSH
• Placenta abnormalities   MeSH
• Check Tag
• Adult MeSH
• Female MeSH
• Publication type
• Case Reports MeSH

• Keywords
• morfologické změny placenty,
• MeSH
• Biomedical Research MeSH
• Adult MeSH
• Skin Tests * methods   utilization   MeSH
• Culture Techniques methods   utilization   MeSH
• Humans MeSH
• Infant, Newborn MeSH
• Placenta * abnormalities   physiopathology   pathology   MeSH
• Pyrimethamine administration & dosage   therapeutic use   MeSH
• Statistics as Topic MeSH
• Toxoplasmosis * diagnosis   microbiology   parasitology   MeSH
• Zoonoses MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Infant, Newborn MeSH
• Female MeSH