Although Pasteurella multocida serogroup F has been described as an avian-adapted serogroup, it was recently found in rabbit nests in the Czech Republic. Therefore, the ability of 2 avian P. multocida serogroup F strains to induce disease in rabbits was investigated. Two groups of 18 Pasteurella-free rabbits were intranasally challenged with strains isolated from chickens and turkeys. Half of the animals in each challenge group were immunosuppressed using dexamethasone. All of the challenged rabbits exhibited clinical signs of peracute septicemic disease, ending with shock, and died or were euthanized in the terminal stages of the disease 1 to 2 d post-infection. Gross pathological changes included systemic vascular collapse and vascular leak syndrome. Hyperemia, hemorrhage, edema, inflammatory cell infiltrates, focal necrosis, and degenerative changes were observed histologically in parenchymatous organs. This is the first study directly demonstrating that avian P. multocida serogroup F strains are highly virulent in rabbits and that avian hosts cannot be excluded as a possible source of rabbit infection with serogroup F.

• MeSH
• cholera veterinární   MeSH
• DNA bakterií analýza   genetika   MeSH
• infekce bakteriemi rodu Pasteurella mikrobiologie   patologie   přenos   veterinární   MeSH
• králíci mikrobiologie   MeSH
• krocani mikrobiologie   MeSH
• kur domácí mikrobiologie   MeSH
• multilokusová sekvenční typizace veterinární   MeSH
• nemoci drůbeže MeSH
• Pasteurella multocida klasifikace   genetika   izolace a purifikace   patogenita   MeSH
• pulzní gelová elektroforéza veterinární   MeSH
• techniky typizace bakterií veterinární   MeSH
• virulence MeSH
• zvířata MeSH
• Check Tag
• králíci mikrobiologie   MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH