V práci sme opísali prípadovú štúdiu pacienta s diagnózou Juvenilná dermatomyozitída. Použili sme 2 svalové testy v štandardizovanej podobe: CMAS - Childhood Myositis Assessment Scale a MMT - Manual Muscle Test, Kendallov test. Sledovali sme hodnoty svalových testov v časovom rozpätí máj 2012 - marec 2014 počas celej liečby v pravidelných časových intervaloch. Hodnoty oboch testov počas prvých štyroch mesiacov výrazne klesali, čo by sme mohli pripísať rozvíjajúcemu sa ochoreniu. Po 21 mesiacoch liečby hodnoty svalových testov sú na podobnej úrovni ako na začiatku ochorenia. Z 3 položiek CMAS na hodnotenie svalovej vytrvalosti došlo k výraznej aktivácii hlbokých flexorov krku. Brušné svalstvo ostalo naďalej oslabené.

We describe the case report of a patient with Juvenile Dermatomyositis . In the thesis we used 2 standardized muscle tests: CMAS - Childhood Myositis Assessment Scale and MMT- Manual Muscle Test, Kendall test. We observed muscle test values in the timeframe May 2012- March 2014 during the whole cure in regular intervals. The values of the both tests were significantly dropping during the first four months this can be attributed to development of the disease. After 21 months of the cure, the muscle tests results are rather close to the results at the beginning of the disease. Of the 3 parts of evaluating muscle endurance, the deep neck flexors have improved by great margin. Abdominal muscles remain weak.

• Klíčová slova
• CMAS - Childhood Myositis Assessment Scale, MMT - Manual Muscle Test,
• MeSH
• časové faktory MeSH
• dermatomyozitida * diagnóza   terapie   MeSH
• dítě MeSH
• dolní končetina fyziologie   MeSH
• hlava fyziologie   MeSH
• kosterní svaly fyziologie   MeSH
• lidé MeSH
• pohybová aktivita fyziologie   MeSH
• progrese nemoci MeSH
• rameno fyziologie   MeSH
• statistika jako téma MeSH
• stupeň závažnosti nemoci MeSH
• svalová síla * fyziologie   MeSH
• techniky fyzikální terapie * MeSH
• terapie cvičením metody   psychologie   MeSH
• tolerance zátěže MeSH
• výsledek terapie MeSH
• zátěžový test statistika a číselné údaje   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH

BACKGROUND: The structural and functional changes of the skeletal muscles in idiopathic inflammatory myopathies (IIM) caused by inflammation and immune changes can be severely disabling. The objective of this study was to assess the effect of a 24-week program combining a supervised training of activities of daily living (ADL), resistance, and stability with home exercise for improving muscle function, compared to a daily home-based exercise representing the regular outpatient care. METHODS: Fifty-seven patients with IIM were consecutively and non-selectively enrolled in an intervention (IG, n = 30) or control (CG, n = 27) group. Both groups were provided a standard-of-care pharmacological treatment and follow-up. Only the IG underwent the supervised intervention twice a week for 1 h per session. At baseline, 12, 24, and 48 weeks, all patients were assessed by an assessor blinded to the intervention for primary outcomes: muscle strength (Manual Muscle Testing of eight muscle groups [MMT-8]) and endurance (Functional Index-2 [FI-2]), and secondary outcomes: stability and body composition. Secondary outcomes also included questionnaires evaluating disability (Health Assessment Questionnaire [HAQ]), quality of life (Short Form 36 [SF-36]), depression (Beck's Depression Inventory-II [BDI-II]), and fatigue (Fatigue Impact Scale [FIS]), and analysis of the systemic and local inflammatory response and perceived exertion to assess the safety of the intervention. RESULTS: Twenty-seven patients in the IG and 23 in the CG completed the entire program and follow-up. At week 24, compared to deterioration in the CG, we found a significant improvement in the IG in muscle strength (mean % improvement compared to baseline by 26%), endurance (135%), disability (39%), depression (26%), stability (11%), and basal metabolism (2%) and a stabilization of fitness for physical exercise. The improvement was clinically meaningful (a 24-week change by >20%) in most outcomes in a substantial proportion of patients. Although the improvement was still present at 48 weeks, the effect was not sustained during follow-up. No significant increase in the systemic or local expression of inflammatory markers was found throughout the intervention. CONCLUSIONS: This 24-week supervised intervention focused on ADL training proved to be safe and effective. It not only prevented the progressive deterioration, but also resulted in a significant improvement in muscle strength, endurance, stability, and disability, which was clinically meaningful in a substantial proportion of patients. TRIAL REGISTRATION: ISRCTN35925199 (retrospectively registered on 22 May 2020).

• MeSH
• činnosti denního života * MeSH
• kosterní svaly MeSH
• kvalita života MeSH
• lidé MeSH
• myozitida * MeSH
• následné studie MeSH
• svalová síla MeSH
• terapie cvičením MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

• Klíčová slova
• Angličtina, Fyziatrie, rehabilitace, balneologie, Jazyky, komunikace, etika,
• MeSH
• fyzioterapie (obor) výchova   MeSH
• lingvistika MeSH
• studium lékařství MeSH
• terminologie jako téma MeSH

• NLK Obory
• lingvistika, lékařská terminologie
• rehabilitační a fyzikální medicína
• pedagogika

• Klíčová slova
• angličtina,
• MeSH
• fyzioterapie (obor) výchova   MeSH
• lingvistika MeSH
• studium lékařství MeSH
• terminologie jako téma MeSH
• Publikační typ
• učebnice MeSH

• Konspekt
• Angličtina
• Učební osnovy. Vyučovací předměty. Učebnice
• NLK Obory
• lingvistika, lékařská terminologie
• rehabilitační a fyzikální medicína
• pedagogika