Mosquito-borne diseases (including malaria) belong among the leading causes of death in humans. Vector control is a crucial part of the global strategy for management of mosquito-associated diseases, when insecticide use is the most important component in this effort. However, drug and insecticide resistance threaten the successes made with existing methods. Reduction or elimination of malaria is not possible without effective mosquito control. This article reviews current strategies of intervention in vector control to decrease transmission of disease and covers current relevant knowledge in molecular biology, biochemistry, and medicinal chemistry.
- MeSH
- Acetylcholinesterase chemistry metabolism MeSH
- Anopheles parasitology MeSH
- Insecticides chemistry pharmacology MeSH
- Mosquito Vectors drug effects MeSH
- Humans MeSH
- Malaria parasitology pathology MeSH
- Drug Design MeSH
- Insecticide Resistance * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
... control 4 -- 3.3 Objectives of the Study Group 4 -- 3.4 Use of DDT in vector control 5 -- 4. ... ... Global status and trends in malaria and other mosquito-borne diseases 5 -- 5. ... ... Vector control in the context of the Global Malaria Control Strategy 14 -- 6.1 Objective of vector control ... ... Managerial aspects of malaria vector control and entomological services 49 -- 12.1 Management of vector ... ... Cost-effectiveness in vector control 63 iv -- 17. ...
WHO technical report series ; No. 857
VI, 91 s. : tab. ; 22 cm
- Conspectus
- Patologie. Klinická medicína
- NML Fields
- infekční lékařství
- NML Publication type
- publikace WHO
Ciba Foundation symposium ; 200
X, 331 s. : obr., tab., grafy ; 24 cm
Mosquitoes (Diptera: Culicidae) act as vectors of medical and veterinary importance, due to their ability to transmit many pathogens and parasites. Renewed interest has been recently devoted to the potential of sterile insect technique (SIT) for mosquito suppression. However, the success of the SIT is mostly dependent on the ability of sterile males to compete for mates with the wild ones in the field. Nevertheless, little is known on the sexual chemical ecology of mosquitoes, with special reference to the role of chemical signals in males. We reviewed the current knowledge on mosquito sexual chemical ecology and other key cues affecting courtship and mating behavior. The information available on the aggregation and sex pheromones in mosquito males is rather limited. To the best of our knowledge, the components of the aggregation pheromone stimulating swarming mechanisms have been fully characterized only for Aedes aegypti, while evidence for aggregation pheromones in other mosquito species remains elusive. Further research on this issue is needed, as well as to dissect the relative importance of visual (with special reference to swarming landmarks), vibrational, olfactory and tactile cues perceived during swarming and mate. On the other hand, more knowledge is available for cuticular hydrocarbons, which modulate mating behavior in several species of economic importance. These compounds, coupled with volatile aggregation components, have potential interest for the development of monitoring and trapping systems. In addition, the analyses of cuticular hydrocarbons are essential for discrimination between closely related mosquito species and/or populations.
- MeSH
- Aedes physiology MeSH
- Pest Control, Biological methods MeSH
- Culicidae physiology MeSH
- Pheromones physiology MeSH
- Infertility MeSH
- Mosquito Vectors * MeSH
- Mosquito Control methods MeSH
- Reproduction MeSH
- Sexual Behavior, Animal * MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Mosquito-borne diseases such as Dengue fever, Chikungunya, and Malaria are critical threats to public health in many parts of the world. Female mosquitoes have evolved multiple adaptive mechanisms to hematophagy, including the ability to efficiently draw and digest blood, as well as the ability to eliminate excess fluids and toxic by-products of blood digestion. Pathogenic agents enter the mosquito digestive tract with the blood meal and need to travel through the midgut and into the hemocele in order to reach the salivary glands and infect a new host. Pathogens need to adjust to these hostile gut, hemocele, and salivary gland environments, and when possible influence the physiology and behavior of their hosts to enhance transmission.
