Psychoactive compounds
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OBJECTIVE: The aim of this study was to assess the frequency of exposure to psychoactive compounds amongst students of the Medical University of Bialystok. METHOD: This cross-sectional study included 504 students selected by means of stratified sampling based on the university faculty, study discipline and year, and participant's gender. RESULTS: Nearly three fourths of our respondents have contact with their student colleagues who use psychoactive compounds, or have heard that such individuals exist. Approximately one fourth of the students declared that they considered using psychoactive compounds at least once. Marijuana and hashish were the psychoactive compounds our respondents used most frequently. Median age of the first contact with these substances was 18 years. Alarmingly high fraction of respondents declared that most of psychoactive compounds included in the study is easily available and obtaining them would not take them longer than one day. Furthermore, 15% of respondents admitted to being involved in the distribution of psychoactive compounds. CONCLUSION: The exposure of medical university students to psychoactive compounds represents similar problem as in their peers studying other disciplines. However, in view of its specific consequences (including potential threat to patients' health and life), the problem should not be underestimated.
- MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- poruchy spojené s užíváním psychoaktivních látek epidemiologie MeSH
- průřezové studie MeSH
- psychotropní léky * MeSH
- studenti lékařství * MeSH
- zakázané drogy * MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Polsko epidemiologie MeSH
In this study we analyzed and characterized 29 psychoactive remedies, illicit drugs and their metabolites in single stages of wastewater treatment plants in the capital city of Slovakia. Psychoactive compounds were present within all stages, and tramadol was detected at a very high concentration (706 ng/L). Significant decreases of codeine, THC-COOH, cocaine and buprenorphine concentration were observed in the biological stage. Consequently, we were interested in the possibility of alternative tertiary post-treatment of effluent water with the following aquatic plants: Cabomba caroliniana, Limnophila sessiliflora, Egeria najas and Iris pseudacorus. The most effective plant for tertiary cleansing was I. pseudacorus which demonstrated the best pharmaceutical removal capacity. After 48 h codeine and citalopram was removed with 87% efficiency. After 96 h were all analyzed compounds were eliminated with efficiencies above 58%.
- MeSH
- biodegradace MeSH
- chemické látky znečišťující vodu analýza metabolismus MeSH
- monitorování životního prostředí MeSH
- odpad tekutý - odstraňování MeSH
- odpadní voda analýza MeSH
- psychotropní léky analýza metabolismus MeSH
- rostliny metabolismus MeSH
- zakázané drogy analýza metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Psilocybe cubensis, a widely recognized psychoactive mushroom species, has played a significant role in both historical and modern therapeutic practices. This review explores the complex interplay between genetic diversity, strain variability and environmental factors that shape the biosynthesis of key psychoactive compounds, including psilocybin and psilocin. With many strains exhibiting substantial variability in their phenotypic characteristics and biochemical content, understanding and documenting this diversity is crucial for optimizing therapeutic applications. The review also highlights advances in cultivation techniques, such as submerged fermentation of the mycelium, and innovative analytical methodologies that have improved the precision of compound quantification and extraction. Although there is limited scientific information on P. cubensis due to nearly four decades of regulatory restrictions on psychedelic research, recent developments in genetic and biochemical studies are beginning to provide valuable insights into its therapeutic potential. Furthermore, this review emphasizes key knowledge gaps and offers insights into future research directions to advance the cultivation, scientific documentation of strain diversity, regulatory considerations and therapeutic use of P. cubensis.
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
New psychoactive substances (NPS) are synthesized compounds that are not usually covered by European and/or international laws. With a slight alteration in the chemical structure of existing illegal substances registered in the European Union (EU), these NPS circumvent existing controls and are thus referred to as "legal highs". They are becoming increasingly available and can easily be purchased through both the internet and other means (smart shops). Thus, it is essential that the identification of NPS keeps up with this rapidly evolving market. In this case study, the Belgian Customs authorities apprehended a parcel, originating from China, containing two samples, declared as being "white pigments". For routine identification, the Belgian Customs Laboratory first analysed both samples by gas-chromatography mass-spectrometry and Fourier-Transform Infrared spectroscopy. The information obtained by these techniques is essential and can give an indication of the chemical structure of an unknown substance but not the complete identification of its structure. To bridge this gap, scientific and technical support is ensured by the Joint Research Centre (JRC) to the European Commission Directorate General for Taxation and Customs Unions (DG TAXUD) and the Customs Laboratory European Network (CLEN) through an Administrative Arrangement for fast recognition of NPS and identification of unknown chemicals. The samples were sent to the JRC for a complete characterization using advanced techniques and chemoinformatic tools. The aim of this study was also to encourage the development of a science-based policy driven approach on NPS. These samples were fully characterized and identified as 5F-AMB and PX-3 using (1)H and (13)C nuclear magnetic resonance (NMR), high-resolution tandem mass-spectrometry (HR-MS/MS) and Raman spectroscopy. A chemoinformatic platform was used to manage, unify analytical data from multiple techniques and instruments, and combine it with chemical and structural information.
- MeSH
- hmotnostní spektrometrie MeSH
- lidé MeSH
- magnetická rezonanční spektroskopie MeSH
- odhalování abúzu drog metody MeSH
- psychotropní léky analýza MeSH
- soudní toxikologie MeSH
- zločin zákonodárství a právo MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Belgie MeSH
New psychoactive substances represent serious social and health problem as tens of new compounds are detected in Europe annually. They often show structural proximity or even isomerism, which complicates their analysis. Two methods based on ultra high performance supercritical fluid chromatography and ultra high performance liquid chromatography with mass spectrometric detection were validated and compared. A simple dilute-filter-and-shoot protocol utilizing propan-2-ol or methanol for supercritical fluid or liquid chromatography, respectively, was proposed to detect and quantify 15 cathinones and phenethylamines in human urine. Both methods offered fast separation (<3 min) and short total analysis time. Precision was well <15% with a few exceptions in liquid chromatography. Limits of detection in urine ranged from 0.01 to 2.3 ng/mL, except for cathinone (5 ng/mL) in supercritical fluid chromatography. Nevertheless, this technique distinguished all analytes including four pairs of isomers, while liquid chromatography was unable to resolve fluoromethcathinone regioisomers. Concerning matrix effects and recoveries, supercritical fluid chromatography produced more uniform results for different compounds and at different concentration levels. This work demonstrates the performance and reliability of supercritical fluid chromatography and corroborates its applicability as an alternative tool for analysis of new psychoactive substances in biological matrixes.
- MeSH
- alkaloidy MeSH
- analýza moči metody MeSH
- fenethylaminy moč MeSH
- hmotnostní spektrometrie MeSH
- kalibrace MeSH
- lidé MeSH
- limita detekce MeSH
- methanol moč MeSH
- psychotropní léky analýza MeSH
- reprodukovatelnost výsledků MeSH
- rozpouštědla MeSH
- superkritická fluidní chromatografie * MeSH
- vysokoúčinná kapalinová chromatografie * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
