Semerádová, Daniela* Dotaz Zobrazit nápovědu
BACKGROUND: This study aimed to estimate the impact of climate change on the ranges of crop pest species in Europe. The organisms included in the study were species from the family Tortricidae (Cydia pomonella, Lobesia botrana) and the family Pyralidae (Ostrinia nubilalis), Chrysomelidae beetles (Leptinotarsa decemlineata, Oulema melanopus) and species from the family Aphididae (Ropalosiphum padi, Sitobion avenae). Climate conditions in the year 2055 were simulated using a subset of five representative global circulation models. Model simulations using these climate change scenarios showed significant shifts in the climatic niches of the species in this study. RESULTS: For Central Europe, the models predicted a shift in the ranges of pest species to higher altitudes and increases in the number of generations (NG) of the pests. In contrast, in the southern regions of Europe, the NG is likely to decrease owing to insufficient humidity. The ranges of species are likely to shift to the north. CONCLUSION: Based on the ensemble-scenario mean for 2055, a climate-driven northward shift of between 3° N (O. nubilalis) and 11° N (L. botrana) is expected. The areas that are most sensitive to experiencing a significant increase in climate suitability for future pest persistence were identified. These areas include Central Europe, the higher altitudes of the Alps and Carpathians and areas above 55° N.
- MeSH
- brouci fyziologie MeSH
- druhová specificita MeSH
- klimatické změny * MeSH
- mšice fyziologie MeSH
- můry fyziologie MeSH
- teoretické modely * MeSH
- zeměpis MeSH
- životní prostředí MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
OBJECTIVE: To describe the sonographic characteristics of a lymphocele after pelvic and/or paraaortic lymphadenectomy for gynecological malignancy, analyze and identify ultrasound characteristics related to the symptomatic and asymptomatic lymphoceles. MATERIALS AND METHODS: This is a retrospective analysis of ultrasound examination data collected consecutively in patients after pelvic and/or paraaortic lymphadenectomy in one institution. We recorded the number of lymphoceles, localization, size; ultrasound morphology following International Ovarian Tumor Analysis group classification and symptoms. RESULTS: We described and analyzed 227 lymphoceles (150 asymptomatic and 77 symptomatic) in 161 patients. The asymptomatic lymphocele is typically a thick-walled cystic lesion without vascularization, round and unilocular with anechoic or ground-glass content. The symptomatic lymphocele is typically an oval, or ovoid, unilocular lesion with low-level or anechoic content (ground glass content is unlikely to be present, p < 0.001) and the presence of debris and septations. The lymphocele size (p = 0.001), number of lymphoceles (>1) (p = 0.005), septa (p = 0.002), and debris (p < 0.001) were independent ultrasound features correlating to symptoms development. More than one lymphocele (p = 0.047), septations (p = 0.007) and presence of debris (p < 0.001) were independent ultrasound features correlated to infection. CONCLUSION: Ultrasound features of symptomatic and asymptomatic lymphocele differ. The clues for lymphocele differential diagnosis are the history of lymphadenectomy and the finding cystic lesion with typically ultrasound features of lymphocele, adjacent to great pelvic vessels. Unique ultrasound features of lymphocele may help to distinguish from tumor relapse, hematoma, abscess, seroma or urinoma.
- MeSH
- asymptomatické nemoci MeSH
- lidé středního věku MeSH
- lidé MeSH
- longitudinální studie MeSH
- lymfadenektomie statistika a číselné údaje MeSH
- lymfokela diagnostické zobrazování patologie MeSH
- nádory ženských pohlavních orgánů chirurgie MeSH
- retrospektivní studie MeSH
- senioři MeSH
- ultrasonografie * MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Závěrečná zpráva o řešení grantu Interní grantové agentury MZ ČR
1 svazek : ilustrace, tabulky ; 30 cm
Accurate clinical staging is crucial for the management of patients in early stages of cervical cancer. Ultrasound examination has certain advantages compared to a golden standard of magnetic resonance imaging: dynamic tests combined with functional Doppler display. Ultrasound allows for very accurate local staging and subsequent individualization of treatment. Accuracy of ultrasound is comparable to magnetic resonance imaging, ultrasound, however, requires considerable level of erudition. The proposed project is exploring whether the erudition is transferable, in which parameters and under what conditions, and it sets rules and conditions for obtaining and maintaining erudition in ultrasound of the cervix. This issue is currently widely discussed and is crucial for the introduction of ultrasound into clinical practice in oncogynecology.
Přesný klinický staging je klíčový pro management pacientek v časných stádiích karcinomu děložního hrdla. Ultrazvukové vyšetření má oproti dosud standardně využívané magnetické rezonanci výhodu dynamického vyšetření kombinovaného s funkčním dopplerovským zobrazením, umožňuje velmi přesný lokální staging s následnou individualizací léčby. Přesnost ultrazvuku je srovnatelná s magnetickou rezonancí, ultrazvukové vyšetření však vyžaduje značnou erudici vyšetřujícího. Navrhovaný projekt zkoumá, zda je tato erudice přenositelná, v jakých parametrech a za jakých podmínek, a stanovuje pravidla a podmínky pro získání a udržení erudice v ultrazvukovém vyšetření děložního hrdla. Tato problematika je v současnosti široce diskutována a je klíčová pro zavedení ultrazvuku do běžné klinické praxe v onkogynekologii.
- MeSH
- individualizovaná medicína MeSH
- karcinom diagnóza MeSH
- nádory děložního čípku diagnóza MeSH
- staging nádorů MeSH
- transrektální ultrazvuk o vysoké intenzitě MeSH
- ultrasonografie MeSH
- ženy MeSH
- Konspekt
- Gynekologie. Porodnictví
- NLK Obory
- gynekologie a porodnictví
- onkologie
- NLK Publikační typ
- závěrečné zprávy o řešení grantu IGA MZ ČR
The aim of this study was to assess the diagnostic accuracy of subjective ultrasound evaluation of myometrial invasion of endometrial cancer and to compare its accuracy to objective methods. All consecutive patients with histologically proven endometrial cancer, who underwent ultrasound evaluation followed by surgical staging between January 2009 and December 2011, were prospectively enrolled. Myometrial invasion was evaluated by subjective assessment using ultrasound (<50% or ≥50%) and calculated as deepest invasion/normal myometrium ratio (Gordon's ratio) and as tumor/uterine anteroposterior diameter ratio (Karlsson's ratio). Histological assessment from hysterectomy was considered the gold standard. Altogether 210 patients were prospectively included. Subjective assessment and two objective ratios were found to be statistically significant predictors of the myometrial invasion (AUC = 0.65, p value < 0.001). Subjective assessment was confirmed as the most reliable method to assess myometrial invasion (79.3% sensitivity, 73.2% specificity, and 75.7% overall accuracy). Deepest invasion/normal myometrium (Gordon's) ratio (cut-off 0.5) reached 69.6% sensitivity, 65.9% specificity, and 67.3% overall accuracy. Tumor/uterine anteroposterior diameter (Karlsson's) ratio with the same cut-off reached 56.3% sensitivity, 76.4% specificity, and 68.1% overall accuracy. The subjective ultrasound evaluation of myometrial invasion performed better than objective methods in nearly all measures but showed statistically significantly better outcomes only in case of sensitivity.
- MeSH
- invazivní růst nádoru diagnóza diagnostické zobrazování patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- myometrium diagnostické zobrazování patologie chirurgie MeSH
- nádory endometria diagnóza diagnostické zobrazování patologie chirurgie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ultrasonografie * MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Cíl studie: Podat strukturovaný návod pro základní transabdominální ultrazvukové vyšetření v gynekologii. Typ studie: Sdělení pro praxi. Název a sídlo pracoviště: Onkogynekologické centrum, Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha. Předmět a metoda studie: Po zpracování současné literatury a vlastní zkušenosti předkládáme popis normálního a nejčastějších patologických nálezů při transabdominálním ultrazvukovém vyšetření. Závěr: Samotné vyšetření zpravidla zabere pouze několik minut, může však podat důležitou informaci jak ve smyslu negativním – nezobrazujeme jinou než případně gynekologickou příčinu obtíží, kdy dovolí soustředit se na další cílenou diagnostiku a léčbu, tak ve smyslu pozitivním – odhalí pravděpodobné negynekologické příčiny obtíží, a lze tedy zajistit adekvátní péči pro pacientku neprodleně.
Objective: To present structured guidelines to transabdominal ultrasound examination in gynecology. Subject: Practical guide. Setting: Oncogynecological Center, Department of Obstetrics and Gynecology, Charles University in Prague – First Faculty of Medicine and General Faculty Hospital, Prague. Subject and method: After having gone over the now-a-days literature and summarized our experience, we present description of normal and more frequent and common pathological findings on transabdominal ultrasound. Conclusion: Entire examination takes usually a couple of minutes, but gives much more information to distinguish between potential causes of patient’s difficulties and allows for focusing an adequate diagnostic and therapeutic management.
- Klíčová slova
- diferenciální diagnostika v gynekologii,
- MeSH
- břicho ultrasonografie MeSH
- diferenciální diagnóza MeSH
- lidé MeSH
- ultrasonografie metody MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
Cíl studie: Prezentovat zkušenosti s prováděním ultrazvukově naváděných miniinvazivních výkonů v onkogynekologii. Typ studie: Původní práce. Název a sídlo pracoviště: Onkogynekologické centrum, Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha. Předmět a metoda studie: Pod kontrolou abdominální nebo vaginální ultrazvukovou sondou bylo užito miniinvazivního punkčního přístupu ve třech indikačních skupinách – při diagnostických výkonech (tru-cut biopsie), terapeutických výkonech (punkční drenáž lymfocyst) a paliativních výkonech (zavedení permanentního peritoneálního katétru). Závěr: Miniinvazivní výkony pod ultrazvukovou kontrolou představují soubor dostupných a poměrně jednoduchých metod využitelných v mnoha indikacích nejen v gynekologické onkologii. Lze je použít v celé šíři spektra od diagnostiky po paliaci. Zvládnutí ultrazvukové asistence punkčních výkonů je dovedností, která umožňuje rozšířit spektrum nabízených výkonů v onkogynekologii a zároveň snížit zátěž pro pacientku.
Objective: To present our experience with ultrasound-guided minimally invasive interventions in gynecologic oncology. Subject: Original paper. Setting: Oncogynecological Center, Department of Obstetrics and Gynecology, Charles University in Prague – First Faculty of Medicine and General Faculty Hospital, Prague. Subject and method: We provide minimally invasive punction interventions under ultrasound guidance using either abdominal or vaginal probe in three indication groups – diagnostics (tru-cut biopsy), therapy (punction drainage of lymphocyst) and palliation (insertion of permanent peritoneal catheter). Conclusion: Ultrasound-guided minimally invasive interventions represent a group of accessible and relatively simple methods useful in many indications, not only in gynecologic oncology. Adoption of these methods allows to broadening the spectrum of interventions offered and decreasing patient’s stress.
OBJECTIVE: To analyze the safety, adequacy and accuracy of tru-cut biopsy and to evaluate factors potentially affecting adequacy. METHODS: We analyzed retrospectively a group of patients who had undergone tru-cut biopsy for either primary suboptimally operable tumors, recurrence or suspected non-genital or secondary tumor. Tru-cut biopsy was performed either transvaginally or transabdominally, using an automatic biopsy gun with disposable needle and needle guide attached to the probe. The adequacy, i.e. obtaining a sample sufficient for identification of the origin of the tumor and performance of immunohistochemistry; accuracy, i.e. agreement between biopsy and final postoperative histology; and safety, as determined by complication rate, were assessed. Variables potentially influencing adequacy were analyzed using the orthogonal projections to latent structure method. RESULTS: A total of 195 biopsies were performed on 190 patients. An adequate sample was obtained in 178 (91.3%) biopsies. The final histology was not in agreement with the result from tru-cut biopsy in two out of 118 patients who underwent subsequent surgery (accuracy 98.3%). There were complications in two cases out of the 195 biopsies performed (1.0%). Ascites, elevated CA 125, primary suboptimal operable tumor, serous epithelial ovarian cancer histology, carcinomatosis and vaginal approach were significant positive predictors for the achievement of an adequate sample, while recurrence as an indication, non-serous and non-ovarian histotypes and transabdominal approach were negative predictors. CONCLUSION: Ultrasound-guided tru-cut biopsy is an efficient, minimally invasive, accurate and safe diagnostic method in the management of advanced, recurrent or atypical abdominal and pelvic tumors of probable non-genital origin, where unnecessary laparotomy or laparoscopy can be avoided. The adequacy of tru-cut biopsy is mainly influenced by indication group, histology, site of biopsy and approach. Our analysis can help in counseling the patient before the procedure and helps to explain the possible causes of failure of the procedure.
- MeSH
- biopsie metody MeSH
- dospělí MeSH
- gynekologie metody MeSH
- imunohistochemie MeSH
- intervenční ultrasonografie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- nádory břicha patologie ultrasonografie MeSH
- nádory pánve patologie ultrasonografie MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
INTRODUCTION: This work intends to present a systematic overview of data that have been published so far with regard to methods used for tissue sampling and DNA testing and with regard to the prevalence of human papillomavirus (HPV) DNA in pelvic lymph nodes (LNs) and its prognostic significance. METHODS: The HPV DNA status of LN in women with cervical cancer is being explored as a potential marker of "occult" metastases. Although the presence of HPV DNA in LN usually correlates with its metastatic involvement, there is always a subgroup of HPV-positive but histologically negative LNs. RESULTS: The significance of HPV in negative LNs remains uncertain, although several studies have concluded that HPV is a risk factor of recurrence. CONCLUSIONS: A small group size and a short follow-up are the main limitations for drawing any conclusion concerning prognostic significance of the presence of HPV DNA in LNs.
- MeSH
- Alphapapillomavirus genetika izolace a purifikace MeSH
- DNA virů izolace a purifikace MeSH
- infekce papilomavirem diagnóza epidemiologie patologie virologie MeSH
- karcinom diagnóza epidemiologie patologie virologie MeSH
- lidé MeSH
- lymfatické metastázy MeSH
- lymfatické uzliny chemie metabolismus virologie MeSH
- nádory děložního čípku diagnóza epidemiologie patologie virologie MeSH
- pánev MeSH
- prevalence MeSH
- prognóza MeSH
- retrospektivní studie MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
BACKGROUND: The impairment of spontaneous voiding is the most prominent type of morbidity in the early postoperative period after radical hysterectomy. The aim of our work was to evaluate the parameters affecting the recovery of spontaneous voiding. METHODS: Enrolled were women in whom radical procedure for early-stage cervical cancer was performed in the period from 2006 to 2008. Satisfactory spontaneous voiding was characterized by the reduction of postvoiding urine residuum to 50 mL or less in the course of a whole day. RESULTS: Data from 85 patients were evaluated retrospectively (radical hysterectomy 67, radical parametrectomy 6, and radical trachelectomy 12), of which 35 underwent nerve-sparing modification, 19 underwent type C radicality of procedure, and 31 underwent type D radicality of procedure. Radicality of parametrectomy was the most significant parameter influencing the interval to spontaneous voiding recovery (P < 0.05); significant differences were observed between nerve-sparing and type D procedures. Multivariate analysis revealed 3 significant parameters: procedure radicality (P < 0.001), type of procedure (radical hysterectomy vs radical trachelectomy; P < 0.05), and a negative correlation with body mass index (P < 0.05). Long-term spontaneous voiding impairment lasting more than 6 weeks was observed in 7 patients, of whom 5 had undergone type D procedure. CONCLUSIONS: The radicality of parametrial resection is the most prominent factor determining the interval to spontaneous voiding, with significantly poorer outcomes after type D procedure. Interestingly, another significant parameter in our study was the type of parametrectomy, with better outcomes achieved after radical trachelectomy. Delayed voiding recovery was observed in patients with lower body mass index.
- MeSH
- adenokarcinom patologie chirurgie MeSH
- adenoskvamózní karcinom patologie chirurgie MeSH
- dítě MeSH
- dospělí MeSH
- hysterektomie škodlivé účinky MeSH
- inkontinence moči etiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- močení MeSH
- nádory děložního čípku patologie chirurgie MeSH
- obnova funkce MeSH
- pooperační komplikace MeSH
- pooperační období MeSH
- prognóza MeSH
- retrospektivní studie MeSH
- senioři MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH