- Autor
-
Pracoviště
Artesadhana Studio Mérida 97000 Mexico 1 Centro de Investigación y Documentaci... 1 Facultad de Veterinaria Universidad d... 1 Faculty of Science University of Sout... 1 León Viera Studio Calle 60 No 338 M p... 1 Raúl Cordero Studio Calle Rio Elba 21... 1 SaBio Instituto de Investigación en R... 1 SaBio Instituto de Investigación en R... 1 UMR BIPAR INRA ANSES Ecole Nationale ... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
- Autor
-
Pracoviště
Artesadhana Studio Mérida 97000 Mexico 1 Centro de Investigación y Documentaci... 1 Facultad de Veterinaria Universidad d... 1 Faculty of Science University of Sout... 1 León Viera Studio Calle 60 No 338 M p... 1 Raúl Cordero Studio Calle Rio Elba 21... 1 SaBio Instituto de Investigación en R... 1 SaBio Instituto de Investigación en R... 1 UMR BIPAR INRA ANSES Ecole Nationale ... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
Soto, Leandro* Dotaz Zobrazit nápovědu
- Artigas-Jerónimo, Sara
- Comín, Juan J Pastor
- Villar, Margarita
- Contreras, Marinela
- Alberdi, Pilar
- Viera, Israel León
- Soto, Leandro
- Cordero, Raúl
-
Valdés, James J
Autor Valdés, James J Faculty of Science, University of South Bohemia, 37005 České Budějovice, Czech Republic. Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Branišovská 1160/31, 37005 České Budějovice, Czech Republic.. Department of Virology, Veterinary Research Institute, Hudcova 70, 62100 Brno, Czech Republic
- Cabezas-Cruz, Alejandro
NLK
Directory of Open Access Journals
od 2013
Free Medical Journals
od 2013
PubMed Central
od 2013
Europe PubMed Central
od 2013
ProQuest Central
od 2013-03-01
Open Access Digital Library
od 2013-01-01
Open Access Digital Library
od 2013-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2013
PubMed
32046307
DOI
10.3390/vaccines8010077
Knihovny.cz E-zdroje
The main objective of this study was to propose a novel methodology to approach challenges in molecular biology. Akirin/Subolesin (AKR/SUB) are vaccine protective antigens and are a model for the study of the interactome due to its conserved function in the regulation of different biological processes such as immunity and development throughout the metazoan. Herein, three visual artists and a music professor collaborated with scientists for the functional characterization of the AKR2 interactome in the regulation of the NF-κB pathway in human placenta cells. The results served as a methodological proof-of-concept to advance this research area. The results showed new perspectives on unexplored characteristics of AKR2 with functional implications. These results included protein dimerization, the physical interactions with different proteins simultaneously to regulate various biological processes defined by cell type-specific AKR-protein interactions, and how these interactions positively or negatively regulate the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway in a biological context-dependent manner. These results suggested that AKR2-interacting proteins might constitute suitable secondary transcription factors for cell- and stimulus-specific regulation of NF-κB. Musical perspective supported AKR/SUB evolutionary conservation in different species and provided new mechanistic insights into the AKR2 interactome. The combined scientific and artistic perspectives resulted in a multidisciplinary approach, advancing our knowledge on AKR/SUB interactome, and provided new insights into the function of AKR2-protein interactions in the regulation of the NF-κB pathway. Additionally, herein we proposed an algorithm for quantum vaccinomics by focusing on the model proteins AKR/SUB.
- Publikační typ
- časopisecké články MeSH
Upřesnit dle MeSH
Sdílet
Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.