Thermolysis Dotaz Zobrazit nápovědu
BACKGROUND: Patients with significant medical and social pro Blems resulting from impaired perfusion of the upper lim Bs caused By micro- or macro-angiopathy are now frequent in clinical practice. Vasospastic disease of the upper lim Bs of com Bined origin is a difficult condition to treat By conservative methods and therapeutic strategies are usually multidisciplinary. In addition to standard pharmacotherapy, treatment may involve regional anaesthesia, thoracoscopic or radiofrequency sympathectomy and surgical treatment of defects, including plastic surgery. METHODS: This paper descri Bes our successful work in the treatment of upper lim B critical ischemia using radiofrequency upper thoracic sympathectomy. RESULTS: In three case reports we present the results of radiofrequency thermolysis applied to treat patients with chronic defects of the hand and fingers. These patients were diagnosed with upper lim B critical ischemia of com Bined origin, standard conservative treatment methods failed and surgical intervention was originally not indicated, however, radiofrequency thermolysis proved to Be Beneficial. CONCLUSIONS: Radiofrequency thoracic sympathectomy could improve peripheral perfusion of the upper lim Bs and there By contri Bute to healing of chronic defects, reduction of pain and improvement in the quality of life of the patients.
- MeSH
- arteria radialis chirurgie MeSH
- arteria ulnaris chirurgie MeSH
- dospělí MeSH
- elektřina MeSH
- ischemie chirurgie MeSH
- lidé středního věku MeSH
- lidé MeSH
- prsty ruky * krevní zásobení chirurgie MeSH
- ruka krevní zásobení chirurgie MeSH
- sympatektomie metody MeSH
- sympatický nervový systém chirurgie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
The project involves determination of the activation energies and physical models for thermolysis of BCHMX and its PBXs. The initial decomposition pathways were also proposed on the basis of molecular dynamic simulation. The goal is to find the mutual relationships among the physical models, decomposition pathways, and the impact sensitivities for BCHMX and its PBXs. It has been shown that the physical model of the first step of BCHMX thermolysis is close to first order and the second step is governed by a first order autocatalytic model, which turns to "2D or 3D Nucleation and Growth" models under the effect of polymeric binders probably due to their hindrances on topochemical reaction of BCHMX. Simulation results show that the scission of N-NO2 is the initial step for BCHMX pyrolysis, followed by HONO and HNO eliminations, where the latter is due to nitro-nitrite rearrangement. Under the effect of hydrocarbon polymers, the HONO/HON elimination and collapse of ring structure of BCHMX occur earlier without changing the time for N-NO2 scission, which might be the reason why those polymers have little effect on the thermal stability of BCHMX, while they could make it decompose almost in a single complex step.
