• MeSH
• Antigens, Viral MeSH
• Animal Experimentation MeSH
• Immunologic Techniques MeSH
• Mammary Glands, Animal MeSH
• Mice MeSH
• Cell Transformation, Neoplastic immunology   physiopathology   MeSH
• Oncogenic Viruses analysis   immunology   MeSH
• Radioimmunoassay MeSH
• Check Tag
• Mice MeSH

• MeSH
• Sarcoma, Experimental drug therapy   MeSH
• Mice MeSH
• Cell Transformation, Neoplastic drug effects   MeSH
• Neoplasms diet therapy   prevention & control   MeSH
• Vitamin A Deficiency pathology   MeSH
• Vitamin A analysis   MeSH
• Animals MeSH
• Check Tag
• Mice MeSH
• Animals MeSH

• MeSH
• Melanoma etiology   MeSH
• Neoplastic Processes genetics   metabolism   MeSH
• Fish Diseases MeSH
• Retroviridae MeSH
• Publication type
• Review MeSH

• Keywords
• onkologové - konference/Bethesda,1988/ - sborníky prací, onkogeneze myeloidní - mechanismy - sborníky prací,

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• onkologie
• mikrobiologie, lékařská mikrobiologie
• embryologie a teratologie
• cytologie, klinická cytologie
• genetika, lékařská genetika
• histologie

• MeSH
• Cell Differentiation MeSH
• Doxycycline administration & dosage   MeSH
• Sarcoma, Experimental MeSH
• Genes, myc drug effects   MeSH
• Mice MeSH
• Bone Neoplasms MeSH
• Oncogenes physiology   drug effects   MeSH
• Animals MeSH
• Check Tag
• Mice MeSH
• Animals MeSH
• Publication type
• Comparative Study MeSH

• MeSH
• Mice MeSH
• Cell Transformation, Neoplastic MeSH
• Lung Neoplasms chemically induced   MeSH
• Nitrosamines toxicity   MeSH
• Check Tag
• Mice MeSH

• MeSH
• Neoplasms, Experimental MeSH
• Phorbols MeSH
• Carboxylic Acids MeSH
• Mice MeSH
• Skin Neoplasms MeSH
• Animals MeSH
• Check Tag
• Mice MeSH
• Animals MeSH
• Publication type
• Comparative Study MeSH

The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further established their critical role in the initiation, promotion and progression of cancer by creating a tumorigenesis-prone microenvironment, thus orchestrating processes of evasion to apoptosis, angiogenesis and invasion/migration, as well metastasis. Given the involvement of miRNAs in tumour development and their global deregulation, they may be perceived as biomarkers in cancer of therapeutic relevance.

• MeSH
• Carcinogenesis genetics   metabolism   MeSH
• Humans MeSH
• Metabolic Networks and Pathways * MeSH
• MicroRNAs genetics   MeSH
• Biomarkers, Tumor genetics   MeSH
• Tumor Microenvironment MeSH
• Oncogene Proteins genetics   metabolism   MeSH
• Gene Expression Regulation, Neoplastic MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Review MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• onkologie

• MeSH
• Endopeptidases metabolism   MeSH
• Research Support as Topic MeSH
• Bone Morphogenetic Proteins metabolism   MeSH
• Mutation, Missense genetics   MeSH
• Neoplasms genetics   metabolism   MeSH
• Proteins metabolism   MeSH
• Proto-Oncogene Proteins genetics   metabolism   MeSH
• Signal Transduction MeSH
• Transforming Growth Factor beta agonists   genetics   MeSH
• Ubiquitin metabolism   MeSH
• Ubiquitin-Protein Ligases metabolism   MeSH