... Presented in the Context of Self-МНС Alleles • Evidence Suggests Distinct Antigen Processing and ... ... Presentation Pathways -- The Endogenous Pathway of Antigen Processing and Presentation • Peptides ... ... Are Generated by Protease Complexes Called Proteasomes • Peptides Are Transported from the Cytosol ... ... to the Rough Endoplasmic Reticulum • Chaperones Aid Peptide Assembly with MHC Class Molecules -- The ... ... Exogenous Pathway of Antigen Processing and Presentation • Peptides Are Generated from Internalized ...

... Sensor cells express pattern recognition receptors that provide an initial discrimination between self ... ... receptors recognize antigens by fundamentally different mechanisms. 1-11 Antigen-receptor genes are assembled ... ... 107 -- 3-16 Cytokine receptors of the hematopoietin family are associated with the JAK family of tyrosine ... ... are generated from ubiquitinated proteins in the cytosol by the proteasome. 216 -- 6-3 Peptides from ... ... . 643 -- 15- 1 A critical function of the immune system is to discriminate self from nonself. 643 -- ...

... Pattern recognition receptors of the innate immune system provide an initial discrimination between self ... ... chemical structures, whereas the T-cell receptor is specialized to recognize foreign antigens as peptide ... ... an early defense against certain tracellular infections. 113 -- 21 NK cells possess receptors for self ... ... to the cell surface from two intracellular compartments. 202 -- 6-2 Peptides that bind to MHC class ... ... antigens presented by the same MHC type. 306 -- 8-16 Only thymocytes whose receptors interact with self-peptide ...