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Hidradenitis suppurativa (HS) je chronické onemocnění terminálních pilosebaceózních žláz primárně se projevující bolestivými zánětlivými recidivujícími noduly a abscesy, které opakovaně praskají, a vedou tak k tvorbě píštělí a jizev. Projevy HS lze rozdělit na dvě formy – zánětlivou a nezánětlivou –, které pak určují způsob léčby pacienta. Hidradenitis suppurativa je spojena s četnými komorbiditami, jako jsou např. obezita, kouření, deprese, idiopatické střevní záněty, axiální spondyloartritida aj., proto je klíčová multioborová spolupráce.

Hidradenitis suppurativa (HS) is a chronic disease of the terminal pilosebaceous glands, manifesting primarily by recurrent painful inflammatory nodules and abscesses that tend to rupture and thus form fistulas and scars. Two distinct forms of HS – inflammatory and non‐inflammatory – require different clinical approach. HS is associated with multiple comorbidities including obesity, smoking, depression, inflammatory bowel disease, axial spondylarthritis, etc. Cooperation of various specialists in the management of patients suffering from HS is mandatory.

MeSH
Anti-Bacterial Agents classification therapeutic use MeSH
Hidradenitis Suppurativa * surgery diagnosis drug therapy classification MeSH
Clindamycin therapeutic use MeSH
Comorbidity MeSH
Humans MeSH
Disease Management MeSH
Obesity complications MeSH
Practice Guidelines as Topic MeSH
Tetracyclines therapeutic use MeSH
Check Tag
Humans MeSH
Publication type
Review MeSH

Article

Recidivující impetigo obličeje
[Recurrent impetigo faciei]

Cabalová, Paulína
Author Authority Kožnî oddělenî, Fakultnî nemocnice Ostrava a Lékařská fakulta Ostravské univerzity v Ostravě

Dermatologie pro praxi. 2024 ; 18 (2) : 112-114. [pub] 20240603

ISSN 1802-2960
Medvik
Source

Impetigo is a common infection of the superficial layers of the epidermis which is highly contagious, commonly caused by Staphylococcus aureus or Strep. pyogenes. The prevalence is highest among the little children attending daycare centers, the peak incidence is during summer and fall. Treatment of non-complicated infections involves topical antibiotics, in cases of systemic signs of infection, systemic oral antibiotic treatment is used. Impetigo is often self-limiting and resolves without scarring, the most common complication, especially during summer, is hyperpigmentation of the skin.

MeSH
Impetigo * drug therapy MeSH
Clindamycin therapeutic use MeSH
Methicillin-Resistant Staphylococcus aureus * pathogenicity drug effects MeSH
Face * microbiology pathology MeSH
Aged, 80 and over MeSH
Check Tag
Male MeSH
Aged, 80 and over MeSH
Publication type
Case Reports MeSH

Article

A rare case of postoperative Metamycoplasma hominis surgical site infection in a patient after bilateral lung transplantation

Folia microbiologica. 2024 ; 69 (3) : 693-696. [pub] 20240416

Folia microbiol. (Prague)
ISSN 1874-9356
Medvik
Source

Following the COVID-19 infection, the sternum dislocation and wound dehiscence resulted in an infection complicating the recovery of an immunosuppressed patient after bilateral lung transplantation. Anaerobic culture (96 h) of milky cloudy wound secretion resulted in the growth of pinpoint haemolytic colonies identified as Metamycoplasma hominis (formerly Mycoplasma hominis). The search for the endogenous source of the infection found the bacterium exclusively in the patient's sputum, making a possible link to donor lung M. hominis colonization. Unfortunately, the donor samples were no longer available. The wound infection was successfully treated with 17 days of clindamycin despite the continuous PCR detection of M. hominis in the sputum after the end of the treatment.

MeSH
Anti-Bacterial Agents therapeutic use MeSH
COVID-19 diagnosis MeSH
Immunocompromised Host MeSH
Surgical Wound Infection * microbiology drug therapy diagnosis MeSH
Clindamycin therapeutic use MeSH
Middle Aged MeSH
Humans MeSH
Mycoplasma hominis * genetics isolation & purification MeSH
Mycoplasma Infections * microbiology diagnosis drug therapy MeSH
SARS-CoV-2 genetics isolation & purification MeSH
Sputum microbiology MeSH
Lung Transplantation * adverse effects MeSH
Check Tag
Middle Aged MeSH
Humans MeSH
Male MeSH
Publication type
Journal Article MeSH
Case Reports MeSH

Article

Liquid chromatography-tandem mass spectrometry methods for quantification of total and free antibiotic concentrations in serum and exudate from patients with post-sternotomy deep sternal wound infection receiving negative pressure wound therapy

Clinica chimica acta. 2024 ; 554 (-) : 117704. [pub] 20240106

Clin Chim Acta
ISSN 1873-3492
Medvik
Source

BACKGROUND: Systemically administered antibiotics are thought to penetrate the wounds more effectively during negative pressure wound therapy (NPWT).To test this hypothesis total and free antibiotic concentrations were quantified in serum and wound exudate. METHODS: UHPLC-MS/MS methods were developed and validated for the determination of ceftazidime, cefepime, cefotaxime, cefuroxime, cefazolin, meropenem, oxacillin, piperacillin with tazobactam, clindamycin, ciprofloxacin, sulfamethoxazole/trimethoprim (cotrimoxazole), gentamicin, vancomycin, and linezolid. The unbound antibiotic fraction was obtained by ultrafiltration using a Millipore Microcon-30kda Centrifugal Filter Unit. Analysis was performed on a 1.7-μm Acquity UPLC BEH C18 2.1 × 100-mm column with a gradient elution. RESULTS: The validation was performed for serum, exudates and free fractions. For all matrices, requirements were met regarding linearity, precision, accuracy, limit of quantitation, and matrix effect. The coefficient of variation was in the range of 1.2-13.6%.and the recovery 87.6-115.6%, respectively. Among the 29 applications of antibiotics thus far, including vancomycin, clindamycin, ciprofloxacin, oxacillin, cefepime, cefotaxime, cotrimoxazole, and gentamicin, total and free antibiotic concentrations in serum and exudate were correlated. CONCLUSION: This method can accurately quantify the total and free concentrations of 16 antibiotics. Comparison of concentration ratios between serum and exudates allows for monitoring individual antibiotics' penetration capacity in patients receiving NPWT.