• MeSH
• duplexní dopplerovská ultrasonografie * MeSH
• falešně pozitivní reakce MeSH
• lidé MeSH
• synovitida ultrasonografie   MeSH
• zápěstí ultrasonografie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• práce podpořená grantem MeSH
• úvodníky MeSH

OBJECTIVES: To investigate the relationship between the body composition and regional bone mineral density (BMD) in postmenopausal women according to years since menopause (YSM). METHODS: A total of 167 postmenopausal women with a mean age of 62.91 ± 5.09 years participated in this cross-sectional study. The average YSM was 11.96 ± 6.28 years. We used the DXA Lunar Prodigy Primo(™) device to assess the body composition parameters [body fat mass (BFM) and lean body mass (LBM)] and the BMD of the lumbar spine, proximal femur and total body. RESULTS: The LBM was a stronger predictor of the proximal femur BMD than BFM in 1-10 YSM category, whereas the BFM was a stronger predictor of the proximal femur BMD than LBM in 11-20 and 21-30 YSM categories. The BMD of the lumbar spine showed a similar trend. A significant relationship was found between BMD of L(1)-L(4) and LBM in 1-10 YSM category (r = 0.26; p < 0.05). BFM was significantly associated with BMD of L(1)-L(4) in 11-20 YSM category (r = 0.25; p < 0.05). Significant relationships were found between total femur BMD and LBM in 1-10 YSM (r = 0.27; p < 0.05) and 11-20 YSM category (r = 0.25; p < 0.05). BFM was significantly associated with total femur BMD only in 11-20 YSM category (r = 0.40; p < 0.05). CONCLUSION: The relationships between BMD and body composition are dependent on YSM and vary between selected segments.

• MeSH
• bederní obratle radiografie   MeSH
• časové faktory MeSH
• femur radiografie   MeSH
• index tělesné hmotnosti MeSH
• kostní denzita fyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• postmenopauza fyziologie   MeSH
• průřezové studie MeSH
• senioři MeSH
• složení těla fyziologie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Statins are well-established lipid-lowering drugs that reduce morbidity and mortality due to cardiovascular disease and cause adverse effects relatively rarely. It is still unclear whether statins are capable of inducing an immune-mediated response directed against skeletal muscle. Here, we present the cases of three patients who developed inflammatory myopathy in the course of statin treatment. Moreover, multiple mitochondrial DNA deletions were found in two of them. The ability of statins to induce an immune-mediated response and their interactions with mitochondrial metabolism pathways are discussed.

• MeSH
• hypercholesterolemie farmakoterapie   MeSH
• kosterní svaly účinky léků   patologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• myozitida chemicky indukované   patologie   MeSH
• senioři MeSH
• statiny škodlivé účinky   farmakologie   terapeutické užití   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• práce podpořená grantem MeSH