This clinical case describes struvite urolithiasis in a pet chipmunk. Physical examination revealed the presence of two ovoid palpable masses in the caudal part of the abdomen, which were later confirmed by radiography as urinary bladder stone. The animal underwent ventral midline laparotomy and uroliths were successfully removed. Uroliths analysis revealed the presence of struvite and bacteriology showed the presence of Proteus mirabilis. Little is known about aetiology and incidence of urolithiasis in chipmunks. Client education about husbandry, dietary needs, and animal behaviour is necessary, especially when dealing with less commonly kept exotic companion mammals. This is the first report of struvite urolithiasis in a pet chipmunk.

• MeSH
• chování zvířat MeSH
• fosfáty MeSH
• nemoci hlodavců * MeSH
• Proteus mirabilis MeSH
• Sciuridae MeSH
• struvit MeSH
• urolitiáza * veterinární   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

SARS-CoV-2 has caused an extensive pandemic of COVID-19 all around the world. Key viral enzymes are suitable molecular targets for the development of new antivirals against SARS-CoV-2 which could represent potential treatments of the corresponding disease. With respect to its essential role in the replication of viral RNA, RNA-dependent RNA polymerase (RdRp) is one of the prime targets. HeE1-2Tyr and related derivatives were originally discovered as inhibitors of the RdRp of flaviviruses. Here, we present that these pyridobenzothiazole derivatives also significantly inhibit SARS-CoV-2 RdRp, as demonstrated using both polymerase- and cell-based antiviral assays.

• MeSH
• adenosinmonofosfát analogy a deriváty   farmakologie   MeSH
• alanin analogy a deriváty   farmakologie   MeSH
• antivirové látky farmakologie   MeSH
• benzothiazoly farmakologie   MeSH
• buněčné linie MeSH
• inhibitory enzymů farmakologie   MeSH
• koronavirová RNA-replikasa antagonisté a inhibitory   MeSH
• lidé MeSH
• mikrobiální testy citlivosti MeSH
• replikace viru účinky léků   MeSH
• SARS-CoV-2 účinky léků   enzymologie   fyziologie   MeSH
• viabilita buněk účinky léků   MeSH
• vztah mezi dávkou a účinkem léčiva MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH