PURPOSE: We report CNS efficacy of first-line osimertinib plus chemotherapy versus osimertinib monotherapy in patients with epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer (NSCLC) from the phase III FLAURA2 study according to baseline CNS metastasis status. METHODS: Patients were randomly assigned to osimertinib plus platinum-pemetrexed (combination) or osimertinib monotherapy until disease progression or discontinuation. Brain scans were performed in all patients at baseline and progression and at scheduled assessments until progression for patients with baseline CNS metastases; scans were assessed by neuroradiologist CNS blinded independent central review (BICR). RESULTS: On the basis of baseline CNS BICR, 118 of 279 (combination) and 104 of 278 (monotherapy) randomly assigned patients had ≥one measurable and/or nonmeasurable CNS lesion and were included in the CNS full analysis set (cFAS); 40 of 118 and 38 of 104 had ≥one measurable target CNS lesion and were included in the post hoc CNS evaluable-for-response set (cEFR). In the cFAS, the hazard ratio (HR) for CNS progression or death was 0.58 (95% CI, 0.33 to 1.01). In patients without baseline CNS metastases, the HR for CNS progression or death was 0.67 (95% CI, 0.43 to 1.04). In the cFAS, CNS objective response rates (ORRs; 95% CI) were 73% (combination; 64 to 81) versus 69% (monotherapy; 59 to 78); 59% versus 43% had CNS complete response (CR). In the cEFR, CNS ORRs (95% CI) were 88% (73 to 96) versus 87% (72 to 96); 48% versus 16% had CNS CR. CONCLUSION: Osimertinib plus platinum-pemetrexed demonstrated improved CNS efficacy compared with osimertinib monotherapy, including delaying CNS progression, irrespective of baseline CNS metastasis status. These data support this combination as a new first-line treatment for patients with EGFR-mutated advanced NSCLC, including those with CNS metastases.

• MeSH
• akrylamidy * MeSH
• aniliny terapeutické užití   MeSH
• erbB receptory genetika   MeSH
• indoly * MeSH
• inhibitory proteinkinas terapeutické užití   MeSH
• lidé MeSH
• mutace MeSH
• nádory centrálního nervového systému * diagnostické zobrazování   farmakoterapie   genetika   MeSH
• nádory plic * farmakoterapie   genetika   patologie   MeSH
• nemalobuněčný karcinom plic * farmakoterapie   genetika   patologie   MeSH
• pemetrexed terapeutické užití   MeSH
• platina terapeutické užití   MeSH
• pyrimidiny * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky, fáze III MeSH
• randomizované kontrolované studie MeSH

• Klíčová slova
• Farmakoterapie pokročilého karcinomu plic (EGFR M+ NSCLC), AZD - 9291 (osimertinib) - selektivní inhibitor EGFR,
• MeSH
• epidermální růstový faktor * antagonisté a inhibitory   genetika   účinky léků   MeSH
• klinické zkoušky, fáze I jako téma metody   využití   MeSH
• kongresy jako téma MeSH
• lidé MeSH
• mutace genetika   imunologie   účinky léků   MeSH
• nemalobuněčný karcinom plic * farmakoterapie   genetika   terapie   MeSH
• statistika jako téma MeSH
• tyrosinkinasy * antagonisté a inhibitory   aplikace a dávkování   terapeutické užití   MeSH
• výsledky a postupy - zhodnocení (zdravotní péče) metody   trendy   využití   MeSH
• Check Tag
• lidé MeSH