Successful treatment of cancer remains a challenge, due to the unique pathophysiology of solid tumors, and the predictable emergence of resistance. Traditional methods for cancer therapy including radiotherapy, chemotherapy, and immunotherapy all have their own limitations. A novel approach is bacteriotherapy, either used alone, or in combination with conventional methods, has shown a positive effect on regression of tumors and inhibition of metastasis. Bacteria-assisted tumor-targeted therapy used as therapeutic/gene/drug delivery vehicles has great promise in the treatment of tumors. The use of bacteria only, or in combination with conventional methods was found to be effective in some experimental models of cancer (tumor regression and increased survival rate). In this article, we reviewed the major advantages, challenges, and prospective directions for combinations of bacteria with conventional methods for tumor therapy.
- MeSH
- Bacteria * genetika metabolismus MeSH
- bakteriální toxiny genetika imunologie metabolismus MeSH
- biologická terapie škodlivé účinky metody MeSH
- enzymy genetika metabolismus MeSH
- klinická studie jako téma MeSH
- kombinovaná terapie metody MeSH
- lidé MeSH
- nádory terapie MeSH
- preklinické hodnocení léčiv MeSH
- systémy cílené aplikace léků MeSH
- technika přenosu genů MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Research Support, N.I.H., Extramural MeSH
