OBJECTIVES: This study aimed to determine whether there is a relationship between common FTO (rs17817449) and MC4R (rs17782313) gene variants and body mass reduction or weight loss after a one-month lifestyle intervention in overweight/obese children. DESIGN AND METHODS: We genotyped 357 unrelated non-diabetic Czech children (age 13.7 ± 4.9 years, average BMI at baseline 30.8 ± 4.6 kg/m(2)). Biochemical and anthropometrical measurements were performed before and after 4 weeks of lifestyle interventions (comprising a reduction in energy intake to the age-matched optimum and a supervised exercise program consisting of 5 exercise units per day, 50 min each). RESULTS: The mean weight loss achieved was 6.2 ± 2.1 kg (P<0.001). Significant associations were found between a BMI decrease and the FTO and MC4R variants. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight compared to noncarriers (P<0.0009 for BMI and P<0.002 for body weight). These differences remained significant following adjustment for sex, age and baseline values (P=0.004 for BMI and P=0.01 for body weight). CONCLUSIONS: FTO and MC4R gene variants modify the impact of an intensive lifestyle intervention on BMI decrease in overweight/obese children. Carriers of the FTO GG genotype and MC4R CC genotype benefit significantly more from the lifestyle intervention.
- MeSH
- dítě MeSH
- energetický příjem MeSH
- frekvence genu MeSH
- genetická epistáze MeSH
- genetické asociační studie MeSH
- index tělesné hmotnosti MeSH
- lidé MeSH
- mladiství MeSH
- nadváha genetika terapie MeSH
- obezita genetika terapie MeSH
- polymorfismus genetický MeSH
- programy na snížení hmotnosti MeSH
- proteiny genetika MeSH
- receptor melanokortinový typ 4 genetika MeSH
- redukční dieta MeSH
- sekvenční analýza DNA MeSH
- terapie cvičením MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- apolipoproteiny A genetika metabolismus MeSH
- dítě MeSH
- haplotypy MeSH
- hmotnostní úbytek * MeSH
- index tělesné hmotnosti MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- mladiství MeSH
- triglyceridy krev MeSH
- životní styl MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- Publikační typ
- dopisy MeSH
- práce podpořená grantem MeSH
