Quorum sensing is a widespread form of cell-to-cell communication, which is based on the production of signaling molecules known as autoinducers (AIs). The first group contains highly species-specific N-acyl homoserine lactones (N-AHLs), generally known as AI-1, which are produced by AHL synthase. The second group, possessing the characteristic structure of a furanone ring, are known as AI-2. The enzyme responsible for their production is S-ribosylhomocysteine lyase (LuxS). In Campylobacter jejuni, AI-2 and LuxS play a role in many important processes, including biofilm formation, stress response, motility, expression of virulence factors, and colonization. However, neither the receptor protein nor the exact structure of the AI-2 molecule have been identified to date. Similarly, little is known about the possible existence of AHL-synthase producing AI-1 and its impact on gene expression. Recently, an analogue of homoserine lactone, called cjA, was isolated from a cell-free supernatant of C. jejuni strain 81-176 and from the food isolate c11. The molecule cjA particularly impacted the expression of virulence factors and biofilm formation. This review summarizes the role of AI-2 and cjA in the context of biofilm formation, motility, stress responses, and expression of virulence factors.

• MeSH
• bakteriální proteiny genetika   metabolismus   MeSH
• biofilmy růst a vývoj   MeSH
• Campylobacter jejuni genetika   metabolismus   patogenita   MeSH
• druhová specificita MeSH
• faktory virulence metabolismus   MeSH
• fyziologický stres fyziologie   MeSH
• gama-butyrolakton analogy a deriváty   genetika   metabolismus   MeSH
• homoserin analogy a deriváty   genetika   metabolismus   MeSH
• laktony metabolismus   MeSH
• quorum sensing MeSH
• regulace genové exprese u bakterií * MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH