- Autor
-
Pracoviště
ADINACO Research Group Department of ... 1 Biomedical Research Centre University... 1 Department of Analytical Chemistry Fa... 1 Department of Bioorganic and Organic ... 1 Department of Chemistry Faculty of Sc... 1 Department of Natural Drugs Faculty o... 1 Department of Pharmacognosy Faculty o... 1 Department of Toxicology and Military... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
- Autor
-
Pracoviště
ADINACO Research Group Department of ... 1 Biomedical Research Centre University... 1 Department of Analytical Chemistry Fa... 1 Department of Bioorganic and Organic ... 1 Department of Chemistry Faculty of Sc... 1 Department of Natural Drugs Faculty o... 1 Department of Pharmacognosy Faculty o... 1 Department of Toxicology and Military... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
- Maříková, Jana
- Mamun, Abdullah Al
- Shammari, Latifah Al
- Korábečný, Jan
- Kučera, Tomáš
-
Hulcová, Daniela
Autor Hulcová, Daniela ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic Department of Pharmacognosy, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
- Kuneš, Jiří
- Malaník, Milan
- Vašková, Michaela
- Kohelová, Eliška
Free Medical Journals od 1997
PubMed Central od 2001
Europe PubMed Central od 2001
ProQuest Central od 1997-01-01
Open Access Digital Library od 1997-01-01
Medline Complete (EBSCOhost) od 2009-03-01
Health & Medicine (ProQuest) od 1997-01-01
PubMed
33652925
DOI
10.3390/molecules26051279
Knihovny.cz E-zdroje
Two new minor Amaryllidaceae alkaloids were isolated from Hippeastrum × hybridum cv. Ferrari and Narcissus pseudonarcissus cv. Carlton. The chemical structures were identified by various spectroscopic (one- and two-dimensional (1D and 2D) NMR, circular dichroism (CD), high-resolution mass spectrometry (HRMS) and by comparison with literature data of similar compounds. Both isolated alkaloids were screened for their human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) inhibition activity. One of the new compounds, a heterodimer alkaloid of narcikachnine-type, named narciabduliine (2), showed balanced inhibition potency for both studied enzymes, with IC50 values of 3.29 ± 0.73 µM for hAChE and 3.44 ± 0.02 µM for hBuChE. The accommodation of 2 into the active sites of respective enzymes was predicted using molecular modeling simulation.
- MeSH
- alkaloidy amarylkovitých chemie farmakologie MeSH
- alkaloidy chemie farmakologie MeSH
- Alzheimerova nemoc MeSH
- butyrylcholinesterasa chemie ultrastruktura MeSH
- cholinesterasové inhibitory chemie farmakologie MeSH
- cholinesterasy chemie ultrastruktura MeSH
- cirkulární dichroismus MeSH
- katalytická doména účinky léků MeSH
- lidé MeSH
- molekulární struktura MeSH
- simulace molekulového dockingu MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Upřesnit dle MeSH
Sdílet
Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.