PURPOSE OF THE STUDY: The critical shoulder angle (CSA) is formed by the combination of glenoid inclination and acromial index and has been shown related to rotator cuff tears and glenohumeral osteoarthritis. SLAP lesions today have an important place among bicipitolabral pathologies that cause intensive shoulder pain. We aimed to investigate the relationship between CSA and glenoid depth and SLAP lesions. MATERIAL AND METHODS: Between March 2017 and January 2022, 279 consecutive shoulder arthroscopy patients' MRI images were retrospectively examined. After the exclusion criteria, 191 patients were eligible. Patients with SLAP lesions (n=37) were assembled as the study group (Group 1), and patients with intact superior labrum (n=154) were named as the control group (Group 2). Critical shoulder angle (CSA) and glenoid depth measurements were performed using the preoperative MRI images. RESULTS: A total of 191 patients, of whom 84 were male (44%) were included. The mean age was 49.9±14.96 (range 18-79). There was a statistically signifi cant difference between the SLAP group (Group 1) and the control group (Group 2) in terms of CSA (p=0.032). The mean CSA was 31.66°±3.51° in Group 1 and 33.57° ±5.01° in Group 2. The cut-off value for CSA in patients with SLAP lesions was calculated as 32.85° and the area under the curve was 0.61, therefore a satisfactory association was observed between the groups. The mean glenoid depth was 4.32 ±1.25 mm in Group 1, and 4.39 ±0.32 mm in Group 2. There was no statistically signifi cant difference between the groups in terms of glenoid depth (p=0.136) and also no association between the glenoid depth and SLAP lesions was observed (cut-off=4.45 mm, AUC=0.32). CONCLUSIONS: Low CSA is associated with SLAP lesions, just as in glenohumeral osteoarthritis. Further prospective clinical studies are needed to enlighten the predisposing effect of CSA to SLAP lesions and the success of superior labral repairs. LEVEL OF EVIDENCE: Retrospective comparative study, Level III.
- MeSH
- akromion MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- lopatka MeSH
- osteoartróza * diagnostické zobrazování chirurgie MeSH
- rameno * MeSH
- retrospektivní studie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVE: Hand osteoarthritis (OA) is a frequent musculoskeletal disorder with an increasing prevalence during ageing. This study aimed to evaluate circulating microRNAs (miRNAs) in the plasma of patients with hand OA compared with age- and sex-matched healthy control subjects. METHODS: In total, 238 participants (96 with erosive and 73 with non-erosive hand OA patients and 69 healthy control subjects) were included in this study. All patients underwent clinical examinations, including self-reported measures (AUSCAN and Algofunctional index). Radiographs of both hands were scored with the Kallman scale. The profile of miRNAs in plasma was screened using TaqManTM Low-Density Array, and candidate miRNAs were validated on two quantitative real-time PCR (qRT-PCR) systems (QuantStudio and SmartChip). RESULTS: Of all the 754 miRNAs, 40 miRNAs were different between hand OA patients and healthy control subjects in the screening cohort. Following the two-phase validation process, three miRNAs (miR-23a-3p, miR-146a-5p, and miR-652-3p) were increased in patients with hand OA compared with healthy control subjects and were associated with the AUSCAN sum score and AUSCAN pain. Furthermore, an inverse correlation of miR-222-3p with the Kallman radiographic score was found. The expression of miRNAs did not differ between erosive and non-erosive hand OA. CONCLUSION: The profile of circulating miRNAs could unveil candidate biomarkers associated with hand OA symptoms. Longitudinal studies are required to determine the role of miRNAs in hand OA.
- MeSH
- biologické markery MeSH
- bolest MeSH
- cirkulující mikroRNA * MeSH
- lidé MeSH
- mikro RNA * MeSH
- osteoartróza * diagnostické zobrazování genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Locking compression plate (LCP) systems are beneficial for treating proximal tibial fractures as they combine the benefits of external and internal fixators, providing greater stability, vascular preservation, superior healing, and fewer complications. However, the translation of these properties to functional benefits for patients remains to be elucidated. Aims: To evaluate the clinical outcomes of tibial plateau fractures (TPFs) treated by LCP and by a combination of posterior and anterior lateral approaches. Methods: This prospective study enrolled 34 patients aged > 18 years, from both genders, with TPFs (Schatzker type 4, 5, 6.) Patients were treated with minimally invasive percutaneous plate osteosynthesis (MIPPO) or open reduction and internal fixation (ORIF) by LCP. They were followed up at 6 weeks, 3 months and 6 months postoperatively. Treatment results were assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results were statistically analyzed using chi-square test and Wilcoxon signed rank test. p ≤ 0.05 indicated statistical significance. Results: With a mean age of 39.29 ± 8.85 years and M:F of 33:1, most patients showed Schatzkers type VI fractures (82.35 %). Anterolateral approach was most used (73.53 %). Most patients achieved good results (44.12 %), showing healing within 14–20 weeks. No association was found between age-group and Schatzkers type (p > 0.05). A significant post-operative reduction in WOMAC scores was noted for total as well as component (pain, stiffness, functional limitation) scores (p < 0.001). Conclusion: LCP is associated with significant improvements in patient’s experience of pain, stiffness and functional limitations.
- Klíčová slova
- locking compression plate, zamykací dlaha,
- MeSH
- dospělí MeSH
- fraktury tibie * chirurgie diagnostické zobrazování klasifikace MeSH
- interní fixátory MeSH
- kostní destičky MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- ortopedické výkony * metody MeSH
- osteoartróza chirurgie diagnostické zobrazování MeSH
- prospektivní studie MeSH
- statistika jako téma MeSH
- vnitřní fixace fraktury metody MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Geografické názvy
- Indie MeSH
Tibiotalocalcaneal arthrodesis (TTCA) is an increasingly used method of stiffening the ankle and subtalar joints in advanced degenerative deformities. The study group consisted of 19 men who were subjected to intramedullary and intraosseous arthrodesis using an intramedullary nail. The average age of patients was 46 (range 19-68) years. The main indication for surgical treatment was post-traumatic arthrosis 11 (58%). In the studied group, clinical condition was assessed using the American Orthopedic Foot and Ankle Score (AOFAS) classification, quality of life using the SF-12 scale, and assessment of pain intensity using the visual-analog scale (VAS) scale. The above parameters were evaluated before surgery (under 2 years), intermediate (from 2 to 5 years), and late (over 5 years) postoperative period. The clinical condition on the AOFAS scale improved from an average of 20.6 points before tibiotalocalcaneal arthrodesis to 63.5 after the procedure. The result was statistically significant (p < .0001). Analyzing the results using the SF-12 scale, a statistically significant increase was found. In the physical sphere of Physical Health Component Score-12 (p = .0004) and in the mental sphere of Mental Health Component Score-12 (p = .030). The intensity of pain assessed in the VAS scale, decreased in all three periods-p < .05. The strongest analgesic effect was observed in the early postoperative follow-up period. Tibiotalocalcaneal arthrodesis using an intramedullary nail causes a significant improvement in the clinical condition according to the AOFAS classification, enabling most patients to move independently, a significant improvement quality of life assessed in the SF-12 scale and a significant reduction of pain ailments assessed in the VAS scale, especially in the early postoperative period.
- MeSH
- artrodéza MeSH
- dospělí MeSH
- hlezenní kloub diagnostické zobrazování chirurgie MeSH
- kostní hřeby MeSH
- kotník MeSH
- kvalita života MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- osteoartróza * diagnostické zobrazování chirurgie MeSH
- retrospektivní studie MeSH
- senioři MeSH
- subtalární kloub * diagnostické zobrazování chirurgie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- kazuistiky MeSH
Osteoarthritis is the most common type of degenerative joint disease and affects millions of people. In this paper, we propose a non-obtrusive and straightforward method to assess the progression of osteoarthritis. In standard medicine praxis, osteoarthritis is observed with X-rays. In this study, we use widely available wearable sensors with gyroscopes to make the observation. Two novel methods are proposed for gyroscope data processing. A small-scale study has shown that these methods can be used to monitor osteoarthritis's progression, and to differentiate between healthy subjects and subjects with femoroacetabular impingement syndrome.
- MeSH
- analgetika terapeutické užití MeSH
- antiflogistika nesteroidní farmakologie škodlivé účinky terapeutické užití MeSH
- antirevmatika * aplikace a dávkování farmakologie klasifikace MeSH
- lidé MeSH
- osteoartróza * diagnostické zobrazování farmakoterapie klasifikace patologie terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Osteoartróza je nejčastější onemocnění kloubů u psů. Znalost patofyziologie umožní cílenou terapii. Terapie kombinuje farmakologickou terapii s rehabilitační terapií, je tedy ve většině případů multimodální. Jako návod pro management pacientů s osteoartrózou mohou sloužit Canine Osteoarthritis Staging Tools (COAST).
Osteoarthritis is the most common joint disease in dogs. Knowledge of the pathophysiology will allow targeted therapy. Therapy combines pharmacological therapy with rehabilitation therapy, thus in most cases it is multimodal. The Canine Osteoarthritis Staging Tools (COAST) can serve as a guide for the management of patients with osteoarthritis.
OBJECTIVES: To determine the prevalence and distribution of US-detected qualitative cartilage damage at metacarpal heads of patients with RA and hand OA. METHODS: Fifty-two RA patients and 34 patients with hand OA were enrolled. US examination of the metacarpal head cartilage from the II to V finger of both hands was performed. A total of 414 MCP joints in RA and 266 MCP joints in OA patients were scanned with a linear probe up to 22 MHz. Qualitative assessments using a previously described scoring system for cartilage damage were performed. The prevalence and distribution of cartilage damage were analysed. Multivariate regression analysis was used to determine the predictive value of age, gender, BMI, disease duration and the presence of RF and anti-CCP antibodies for US-detected cartilage damage. RESULTS: The metacarpal head cartilage was positive for cartilage damage in 35.7% (148/414) of MCP joints in RA and in 43.6% (116/266) of MCP joints in OA patients. In RA, the hyaline cartilage of the II and III metacarpal heads (bilaterally) was the most frequently affected. In OA, cartilage damage was more homogeneously distributed in all MCP joints. Multivariate regression analysis showed that age and disease duration, but not gender, BMI or autoantibody status, were independent predictors of US-detected cartilage damage in RA. CONCLUSION: Cartilage damage was found in more than one-third of the MCP joints in both RA and OA patients, and in RA patients, the II and III MCP joints were the most damaged.
- MeSH
- antirevmatika terapeutické užití MeSH
- autoprotilátky krev MeSH
- dospělí MeSH
- kloubní chrupavka diagnostické zobrazování MeSH
- lidé středního věku MeSH
- lidé MeSH
- metakarpofalangeální kloub diagnostické zobrazování MeSH
- nemoci chrupavky diagnostické zobrazování etiologie MeSH
- osteoartróza komplikace diagnostické zobrazování farmakoterapie MeSH
- radiografie MeSH
- reprodukovatelnost výsledků MeSH
- revmatoidní artritida komplikace diagnostické zobrazování farmakoterapie MeSH
- senioři MeSH
- sexuální faktory MeSH
- stupeň závažnosti nemoci MeSH
- ultrasonografie MeSH
- věkové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- MeSH
- ankylózující spondylitida * diagnostické zobrazování klasifikace MeSH
- diferenciální diagnóza MeSH
- difuzní idiopatická skeletální hyperostóza diagnostické zobrazování MeSH
- lidé MeSH
- osteoartróza diagnostické zobrazování MeSH
- psoriatická artritida diagnostické zobrazování MeSH
- radiografie metody přístrojové vybavení MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- MeSH
- antiflogistika nesteroidní aplikace a dávkování MeSH
- antirevmatika aplikace a dávkování MeSH
- aplikace lokální MeSH
- chondroitinsulfáty terapeutické užití MeSH
- kloub prstu ruky patologie účinky léků MeSH
- klouby ruky diagnostické zobrazování patologie účinky léků MeSH
- lidé MeSH
- osteoartróza * diagnostické zobrazování farmakoterapie klasifikace MeSH
- rizikové faktory MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
