studie Czech post-MONICA Dotaz Zobrazit nápovědu
Podle dosud posledních statistických údajů jsou hlavní příčinou úmrtí v České republice kardiovaskulární onemocnění (KVO), která jsou zodpovědna za 36,5 % úmrtí u mužů a 43,1 % úmrtí u žen. Podle údajů Světové zdravotnické organizace a Evropské kardiologické společnosti patří Česká republika mezi státy vykazující vysokou úmrtnost na KVO. Mezi hlavní rizikové faktory KVO patří dyslipidemie, LDL-cholesterol (LDL-C) byl identifikován jako hlavní determinant rizika pro rozvoj aterosklerózy. Cílem této analýzy studie Czech post-MONICA bylo zjistit hodnoty 95. percentilu pro LDL-C u reprezentativního vzorku české populace v letech 2015–2018. Hodnoty 95. percentilu LDL-C podle věku a pohlaví jsou požadovány pro stanovení míry pravděpodobnosti FH podle Dutch Lipid Network Criteria.
According to the latest statistical data to date, cardiovascular disease (CVD) is the leading cause of death in the Czech Republic, accounting for 36.5% of deaths in men and 43.1% of deaths in women. According to data from the World Health Organization and the European Society of Cardiology, the Czech Republic is one of the countries with a high mortality rate from CVD. The main risk factors for CVD include dyslipidemia, LDL-cholesterol (LDL-C) has been identified as a major determinant of the risk for developing atherosclerosis. The aim of this analysis of the Czech post-MONICA study was to determine the 95th percentile values for LDL-C in a representative sample of the Czech population examined in 2015–2018. The 95th percentile values of LDL-C by age and sex are required to determine the probability of FH according to the Dutch Lipid Network Criteria.
- Klíčová slova
- studie Czech post-MONICA,
- MeSH
- dospělí MeSH
- hyperlipoproteinemie typ II * diagnóza MeSH
- LDL-cholesterol analýza krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- průřezové studie MeSH
- rizikové faktory kardiovaskulárních chorob MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
Kardiovaskulární onemocnění (KVO) jsou hlavní příčinou úmrtí v České republice. Pokles úmrtnosti na KVO, který je u nás pozorován od roku 1985, může být způsoben poklesem incidence nebo letality. Letalita onemocnění souvisí především s úrovní léčebné péče, zatímco incidence KVO je ovlivněna rizikovým profi lem obyvatelstva. Cílem této práce bylo zjistit prevalenci základních rizikových faktorů u reprezentativního vzorku české populace. Metodika: Byl proveden 1% náhodný výběr vzorku populace devíti okresů České republiky ve věku 25–64 let. Vyšetření sestávalo z vyplnění standardního dotazníku, získání základních antropometrických údajů, opakovaného měření krevního tlaku a odběru krve. Výsledky: V období 2015–2018 bylo vyšetřeno celkem 2 621 osob (1 250 mužů, průměrný věk 48,3 ± 10,9 roku a 1 371 žen, průměrný věk 47,7 ± 11,0 roku; p < 0,001); respondence 44,8 %. Průměrná hodnota indexu tělesné hmotnosti (BMI) u námi vyšetřené populace činila 29,1 ± 4,8 kg/m2 u mužů a 27,15 ± 6,1 kg/m2 u žen (p < 0,001). Obezita byla zjištěna u 37,3 % mužů a 28,2 % žen. Mezi vyšetřenými muži 24,8 % uvedlo, že jsou pravidelnými kuřáky, zatímco kouření u žen bylo zjištěno u 21,6 % (p < 0,001). Nalezli jsme vysokou prevalenci hypertenze (48,6 % u mužů a 32,4 % u žen; p < 0,001); 74,3 % hypertoniků ví o svém onemocnění, 61,5 % je medikamentózně léčeno a pouze 33,9 % dosahuje cílových hodnot krevního tlaku < 140/90 mm Hg. Průměrná hodnota celkového cholesterolu u námi vyšetřené populace byla téměř identická pro muže i ženy (muži 5,26 ± 1,03 mmol/l; ženy 5,28 ± 1,00 mmol/l). Hypolipidemiky bylo léčeno 13,9 % mužů a 10,2 % žen (p < 0,001). Diabetes byl zjištěn u 8,2 % mužů a 4,6 % žen (p < 0,001). Prevalence všech základních rizikových faktorů výrazně narůstala s věkem u obou pohlaví (p pro trend < 0,001). Závěr: U reprezentativního náhodně vybraného vzorku české populace středního věku byla nalezena vysoká prevalence základních rizikových faktorů kardiovaskulárních onemocnění, které jsou příčinou stále vysoké mortality z kardiovaskulárních příčin v České republice.
Cardiovascular disease (CVD) is the main cause of death in the Czech Republic. The decline in CVD mortality observed in our country since 1985 may be due to a decrease in its incidence or case fatality. Case fatality is mostly related to the standard of health care whereas the incidence of CVD is associated with the risk profi le of the population. The aim of this study was to determine the prevalence of major CVD risk factors in a representative Czech population sample. Methods: A 1% population sample aged 25–64 years was randomly selected from nine districts of the Czech Republic. The examination consisted of completing a standard questionnaire, obtaining major anthropometric data, repeated blood pressure measurements, and blood sampling. Results: A total of 2621 individuals (1250 males, mean age 48.3 ± 10.9 years, and 1371 females, mean age 47.7 ± 11.00 years; p < 0,001) were screened in 2015–2018 (response rate, 44.8%). Mean BMI in our population was 29.1 ± 4.8 kg/m2 in males and 27.5 ± 6.1 kg/m2 in females (p < 0.001). Obesity was found in 37.3% of males and 28.2% of females. Among the males, 24.8% reported to be regular smokers whereas smoking was found in 21.6% females (p < 0.001). There was a high prevalence of hypertension (48.6% of males and 32.4% of females; p < 0.001); 74.3% of hypertensives were aware of their disease, 61.5% were drug treated, however, only 33.9 % were controlled (blood pressure < 140/90 mmHg). The mean total cholesterol in our population was almost identical in males and females (5.26 ± 1.03 mmol/L and 5.28 ± 1.00 mmol/L, respectively). Lipid-lowering drugs were used by 13.9% of males and 10.2% of females (p < 0.001). Diabetes was found in 8.2% of males and 4.6% of females (p < 0.001). The prevalence of all major risk factors increased signifi cantly with age in both sexes (p for trend < 0.001). Conclusion: A high prevalence of major cardiovascular risk factors was found in a representative Czech population sample, which is the cause of continuing high cardiovascular mortality in the Czech Republic.
- Klíčová slova
- studie Czech post-MONICA,
- MeSH
- cholesterol normy MeSH
- diabetes mellitus 2. typu prevence a kontrola MeSH
- hypertenze komplikace MeSH
- index tělesné hmotnosti MeSH
- kardiovaskulární nemoci * epidemiologie prevence a kontrola MeSH
- kouření škodlivé účinky MeSH
- krevní tlak MeSH
- lidé MeSH
- obezita MeSH
- prevalence MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
Kardiovaskulární onemocnění jsou hlavní příčinou úmrtí v České republice. Pokles úmrtnosti na kardiovaskulární onemocnění, který je u nás pozorován od roku 1985, může být způsoben poklesem incidence nebo letality. Letalita onemocnění souvisí především s úrovní léčebné péče, zatímco incidence kardiovaskulárních onemocnění je ovlivněna rizikovým profi lem obyvatelstva. Cílem této práce bylo zjistit prevalenci základních rizikových faktorů u reprezentativního vzorku české populace. Metodika: Byl proveden 1% náhodný výběr vzorku populace devíti okresů České republiky ve věku 25–64 let. Vyšetření sestávalo z vyplnění standardního dotazníku, získání základních antropometrických údajů, opakovaného měření krevního tlaku a odběru krve. Výsledky: V období 2006–2009 bylo vyšetřeno celkem 3 612 osob (1 737 mužů, průměrný věk 47,8 ± 11,48 roku a 1 875 žen, průměrný věk 46,5 ± 11,20 roku); respondence 62,2 %. Průměrná hodnota BMI u námi vyšetřené populace činila 28,5 ± 4,7 kg/m2 u mužů a 27,1 ± 6,0 kg/m2 u žen (p < 0,001). Obezita byla zjištěna u 32,4 % mužů a 28,3 % žen. Mezi vyšetřenými muži 31,9 % uvedlo, že jsou pravidelnými kuřáky, zatímco kouření u žen bylo zjištěno u 23,3 % (p < 0,001). Nalezli jsme vysokou prevalenci hypertenze (47,8 % u mužů a 36,6 % u žen; p < 0,001); 71,9 % hypertoniků ví o svém onemocnění, 60,3 % je medikamentózně léčeno a 30,9 % dosahuje cílových hodnot krevního tlaku < 140/90 mm Hg. Ženy, ačkoli mají nižší prevalenci hypertenze, častěji vědí o svém onemocnění, častěji jsou medikamentózně léčeny pro hypertenzi a častěji dosahují cílových hodnot krevního tlaku (< 140/90 mm Hg). Průměrná hodnota celkového cholesterolu u námi vyšetřené populace byla identická pro muže i ženy (muži 5,29 ± 1,10 mmol/l; ženy 5,29 ± 1,04 mmol/l). Hypolipidemiky bylo léčeno 12,7 % mužů a 8,5 % žen (p < 0,001). Diabetes mellitus byl zjištěn u 9,4 % mužů a 4,7 % žen (p < 0,001). Prevalence všech základních rizikových faktorů výrazně narůstala s věkem u obou pohlaví (p pro trend < 0,001). Závěr: U reprezentativního, náhodně vybraného vzorku české populace středního věku byla nalezena vysoká prevalence základních rizikových faktorů kardiovaskulárních onemocnění, které jsou příčinou stále vysoké kardiovaskulární mortality v České republice.
Cardiovascular disease (CVD) is the main cause of death in the Czech Republic. The decline in CVD mortality observed in our country since 1985 may be due to a decrease in its incidence or case fatality. Case fatality is mostly related to the standard of health care whereas the incidence of CVD is associated with the risk profi le of the population. The aim of this study was to determine the prevalence of major CVD risk factors in a representative Czech population sample. Methods: A 1% population sample aged 25–64 years was randomly selected from nine districts of the Czech Republic. The examination consisted of completing a standard questionnaire, obtaining major anthropometric data, repeated blood pressure measurements, and blood sampling. Results: A total of 3612 individuals (1737 males, mean age 47.8 ± 11.48 years, and 1875 females, mean age 46.5 ± 11.20 years) were screened in 2006–2009 (response rate, 62.2%). Mean BMI in our population was 28.5 ± 4.7 kg/m2 in males and 27.1 ± 6.0 kg/m2 in females (p < 0,001). Obesity was found in 32.4% of males and 28.3% females. Among the males, 31.9% reported to be regular smokers whereas smoking was found in 23.3% females (p < 0.001). There was a high prevalence of hypertension (47.8% of males and 36.6% of females; p < 0.001); 71.9% of hypertensives were aware of their disease, 60.3% were drug treated, and 30.9 % were controlled (blood pressure < 140/90 mmHg). Females, while having a lower prevalence of hypertension, are more often aware of their disease, are more frequently treated by antihypertensive drugs, and are more often controlled. The mean total cholesterol in our population was identical in males and females (5.29 ± 1.10 mmol/l and 5.29 ± 1.04 mmol/l, respectively). Lipid-lowering drugs were used by 12.7% of males and 8.5% of females (p < 0.001). Diabetes was found in 9.4% of males and 4.7% of females (p < 0.001). The prevalence of all major risk factors increased signifi cantly with age in both sexes (p for trend < 0.001). Conclusion: A high prevalence of major cardiovascular risk factors was found in a representative Czech population sample, which is the cause of continuing high cardiovascular mortality in the Czech Republic.
- Klíčová slova
- Kardiovaskulární onemocnění, Náhodně vybraný populační vzorek, BMI, Celkový cholesterol,
- MeSH
- diabetes mellitus epidemiologie MeSH
- dospělí MeSH
- HDL-cholesterol MeSH
- hypertenze epidemiologie MeSH
- index tělesné hmotnosti MeSH
- kardiovaskulární nemoci MeSH
- kouření epidemiologie MeSH
- krevní tlak MeSH
- LDL-cholesterol MeSH
- lidé středního věku MeSH
- lidé MeSH
- obezita epidemiologie MeSH
- prevalence MeSH
- průřezové studie MeSH
- riziko MeSH
- rizikové faktory MeSH
- senioři MeSH
- statistika jako téma MeSH
- triglyceridy MeSH
- věkové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Geografické názvy
- Česká republika MeSH
BACKGROUND: Compared with Western Europe, the decline in cardiovascular (CV) mortality has been delayed in former communist countries in Europe, including the Czech Republic. We have assessed longitudinal trends in major CV risk factors in the Czech Republic from 1985 to 2016/17, covering the transition from the totalitarian regime to democracy. METHODS: There were 7 independent cross-sectional surveys for major CV risk factors conducted in the Czech Republic in the same 6 country districts within the WHO MONICA Project (1985, 1988, 1992) and the Czech post-MONICA study (1997/98, 2000/01, 2007/08 and 2016/2017), including a total of 7,606 males and 8,050 females. The population samples were randomly selected (1%, aged 25-64 years). RESULTS: Over the period of 31/32 years, there was a significant decrease in the prevalence of smoking in males (from 45.0% to 23.9%; p < 0.001) and no change in females. BMI increased only in males. Systolic and diastolic blood pressure decreased significantly in both genders, while the prevalence of hypertension declined only in females. Awareness of hypertension, the proportion of individuals treated by antihypertensive drugs and consequently hypertension control improved in both genders. A substantial decrease in total cholesterol was seen in both sexes (males: from 6.21 ± 1.29 to 5.30 ± 1.05 mmol/L; p < 0.001; females: from 6.18 ± 1.26 to 5.31 ± 1.00 mmol/L; p < 0.001). CONCLUSIONS: The significant improvement in most CV risk factors between 1985 and 2016/17 substantially contributed to the remarkable decrease in CV mortality in the Czech Republic.
- MeSH
- antihypertenziva terapeutické užití MeSH
- dospělí MeSH
- hypercholesterolemie epidemiologie MeSH
- hypertenze farmakoterapie epidemiologie MeSH
- index tělesné hmotnosti MeSH
- kardiovaskulární nemoci epidemiologie etiologie MeSH
- kouření cigaret epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- morbidita trendy MeSH
- mortalita trendy MeSH
- obezita epidemiologie MeSH
- politika MeSH
- průřezové studie MeSH
- rizikové faktory MeSH
- sociální změna MeSH
- zdraví - znalosti, postoje, praxe MeSH
- zdravotnické přehledy MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
OBJECTIVE: The aim of our study was to assess longitudinal trends in major CV risk factors in a representative population sample of the Czech Republic. METHODS: Three cross-sectional surveys of CV risk factors were conducted within the WHO MONICA project in six Czech districts in 1985 (n=2570), 1988 (n=2768), and 1992 (n=2343). In 1997/98, 2000/01, and 2007/08, another three screenings for CV risk factors (a 1% random sample, aged 25-64, mean age 45 years) were conducted in the six original districts (n=1990; 2055; and 2246, respectively). RESULTS: Over a period of 22/23 years, there was a significant decrease in the prevalence of smoking in males (from 45.0 to 30.5%; p<0.001) and no change in smoking habits in females. BMI increased in males and did not change in females. Both systolic and diastolic blood pressure decreased significantly in both genders, while the prevalence of hypertension declined only in females. Awareness of hypertension also rose as did the proportion of individuals treated by antihypertensive drugs in both genders. Hypertension control improved in either gender. A remarkable drop in total cholesterol was seen in both sexes (males: from 6.21 + or - 1.29 to 5.29 + or - 1.10 mmol/L; p<0.001; females: from 6.18 + or - 1.26 to 5.30 + or - 1.06 mmol/L; p<0.001). CONCLUSIONS: The striking improvement in CV risk factors documented between 1985 and 2007/8 most likely contributed to the decrease in CV mortality in the Czech Republic.
- MeSH
- dospělí MeSH
- hypertenze diagnóza epidemiologie MeSH
- index tělesné hmotnosti MeSH
- kardiovaskulární nemoci diagnóza epidemiologie MeSH
- krevní tlak MeSH
- lidé středního věku MeSH
- lidé MeSH
- longitudinální studie MeSH
- obezita diagnóza epidemiologie MeSH
- průřezové studie MeSH
- rizikové faktory MeSH
- sexuální faktory MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
Purpose: Primary aldosteronism (PA) is considered the most common form of secondary hypertension, however, its prevalence, particularly in a general population, is still a matter of debate. The aim of our study was to evaluate the prevalence of PA in a randomly selected general population sample.Materials and methods: A total of 1940 individuals (1% population random sample) aged 25-64 years were screened for major cardiovascular risk factors in six districts of the Czech Republic. Hypertension was defined as a mean of two blood pressure readings ≥140/90 mmHg at one visit or taking antihypertensive medication. Within this population, 740 individuals were labelled as hypertensives and 650 of them sampled for the analysis of direct plasma renin and serum aldosterone. The diagnosis of PA was based on elevated serum aldosterone, low plasma renin and high aldosterone/renin (ARR) ratio and was also verified by a confirmatory test with saline infusion.Results: Positive ARR was found in 52 (8%) individuals (64% women, 36% men, however, due to substatntial proportion of reluctatnt participants to undergo a further work-up (27%), we could confirm the diagnosis of PA only in 13 of them (2%). Aldosterone-producing adenoma was found in one case only, seven patients had idiopathic type and five individuals refused potential surgical treatment therefore, adrenal venous sampling was not performed.Conclusion: Elevated serum aldosterone together with low renin and high ARR were found in 52 (8%) of hypertensives selected from a general population sample, however, the diagnosis of PA was confirmed only in 13 of them (2%). This study based on a general population survey highlighted the difficulty of conducting epidemiological studies on primary aldosteronism in a relatively healthy cohort part of whom did not provide the level of collaboration that is necessary to assess the true prevalence of this condition.
- MeSH
- aldosteron krev MeSH
- antihypertenziva terapeutické užití MeSH
- biologické markery krev MeSH
- dospělí MeSH
- hyperaldosteronismus krev diagnóza epidemiologie MeSH
- hypertenze diagnóza farmakoterapie epidemiologie patofyziologie MeSH
- krevní tlak účinky léků MeSH
- lidé středního věku MeSH
- lidé MeSH
- prevalence MeSH
- průřezové studie MeSH
- renin krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
Background: Severe hypercholesterolemia is associated with an increase in the risk of developing atherosclerotic cardiovascular disease. The aim of this analysis was to assess longitudinal trends in severe dyslipidemia (defined as total cholesterol > 8 mmol/L or LDL-cholesterol > 5 mmol/L) in a representative population sample of the Czech Republic and to analyze the longitudinal trends in the basic characteristics of individuals with severe dyslipidemia. Methods: Seven independent cross-sectional surveys were organized in the Czech Republic to screen for major cardiovascular risk factors (from 1985 to 2015-2018). A total of 20,443 randomly selected individuals aged 25-64 years were examined. Results: The overall prevalence of severe dyslipidemia was 6.6%, with a significant downward trend from the fifth survey onwards (2000/2001). Over the study period of 30+ years, the individuals with severe dyslipidemia became older, increased in BMI, and did not change their smoking habits. Total cholesterol and non-HDL-cholesterol decreased significantly in both sexes throughout the duration of the study. Conclusions: Despite a significant improvement in lipids in the Czech Republic from 1985, substantially contributing to the decline in cardiovascular mortality, the number of individuals with severe dyslipidemia remained high, and in most cases, they were newly detected during our screening examinations and were thus untreated.
- Publikační typ
- časopisecké články MeSH
Central blood pressure (BP) has been shown to be a better predictor of target organ damage and cardiovascular events than brachial BP. Whether central BP is a better predictor of left ventricular hypertrophy (LVH) determined by electrocardiography (ECG) is not known. Radial applanation tonometry and ECG were performed in 728 subjects from the Czech Post-MONICA Study (a randomly selected 1% population sample). LVH was determined using the Sokolow-Lyon index and Cornell product; central pressure was derived from radial pulse. Of 657 subjects included in the analysis, 17 (9.4%) below 45 years and 43 (9%) over 45 years had LVH. In multiple linear regression analysis, the Sokolow-Lyon index in younger individuals was only associated with male sex and low BMI, with no association with BP found. In older individuals, LVH was associated with higher central and brachial BP. In separate binary logistic regression analyses adjusted for covariates, the odds ratio for central systolic pressure was higher than those for brachial systolic and pulse pressure in LVH prediction. Noninvasively determined central pressure in subjects over 45 years is more strongly related to ECG LVH than brachial pressure. This further supports a closer association of central pressure with target organ damage. Voltage criteria of LVH are not independently associated with central or brachial BP in younger individuals.
- MeSH
- dospělí MeSH
- hypertenze epidemiologie patofyziologie MeSH
- hypertrofie levé komory srdeční diagnóza epidemiologie patofyziologie MeSH
- index tělesné hmotnosti MeSH
- krevní tlak fyziologie MeSH
- lidé MeSH
- prevalence MeSH
- sexuální faktory MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
UNLABELLED: Retinal microcirculation reflects retinal perfusion abnormalities and retinal arterial structural changes at relatively early stages of various cardiovascular diseases. Wall-to-lumen ratio (WLR) may represent the earliest step in hypertension-mediated organ damage.Our objective was to compare functional and structural parameters of retinal microcirculation in a randomly selected urban population sample, in hypertensive and normotensive individuals. DESIGN AND METHOD: A total of 398 randomly selected individuals from an urban population aged 25-65 years, residing in Pilsen, Czech Republic, were screened for major cardiovascular risk factors. Retinal microcirculation was assessed using scanning laser Doppler flowmetry, with data evaluable in 343 patients. Complete data were available for 342 individuals divided into four groups based on blood pressure and control status of hypertension: normotensive individuals ( n = 213), treated controlled hypertensive individuals ( n = 30), treated uncontrolled hypertensive individuals ( n = 26), and newly detected/untreated hypertensive individuals ( n = 73). RESULTS: There was a tendency to higher wall thickness in treated but uncontrolled hypertensive patients (compared to normotensive and treated controlled hypertensive individuals). WLR was significantly increased in treated but uncontrolled hypertensive patients as well as in individuals with newly detected thus untreated hypertension or in patients with known but untreated hypertension. There was no difference in WLR in treated, controlled hypertensive patients compared with normotensive individuals. CONCLUSION: Our results show that an increased WLR, reflecting early vascular damage, was found in newly detected individuals with hypertension and in untreated hypertensive patients, reflecting early hypertension-mediated vascular damage. Early initiation of hypertension treatment may be warranted.
- MeSH
- arterioly MeSH
- hypertenze * MeSH
- krevní tlak MeSH
- lidé MeSH
- mikrocirkulace MeSH
- retinální cévy diagnostické zobrazování MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
AIM: Ankle brachial index (ABI) is a diagnostic tool for peripheral arterial disease (PAD) and a cardiovascular risk stratification tool. Despite this evidence and guidelines recommending its use in everyday practice, ABI is not widely used. Automatic ABI measurement may lower the barrier to incorporate ABI measurement into everyday practice. The aim of this study was to validate a novel automatic oscillometric ABI device (BOSO ABI) against a gold standard-Doppler device in an epidemiological setting. METHODS: In 839 patients from the Czech post-MONICA study (a randomly selected representative population sample aged over 25 years), mean age 54.3±13.8 years (47% of men), ABI measurement was performed using the BOSO ABI device and a handheld Doppler device in a random fashion. The two techniques were carried out by different investigators each blinded to the findings of the other. Analyses were conducted as proposed by Bland and Altman. RESULTS: The mean ABI difference between the two methods was 0.1±0.11, with 95% limits of agreement ranging from -0.11 to 0.30. The difference between Doppler and oscillometric ABI increased significantly with increasing mean ABI (r=0.29; P<0.001). When considering Doppler the gold standard, automated oscillometric measurement had a 76.9% sensitivity, 97.9% specificity, and 37% positive and 99.6% negative predictive values in diagnosing ABI <0.9. CONCLUSION: The BOSO ABI device cannot be used interchangeably for standard Doppler ABI measurement in diagnosing PAD. However, its high negative predictive value allows using it as a screening tool for PAD.
- MeSH
- analýza rozptylu MeSH
- design vybavení MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- onemocnění periferních arterií diagnóza patofyziologie ultrasonografie MeSH
- oscilometrie přístrojové vybavení MeSH
- plošný screening přístrojové vybavení MeSH
- praktické lékařství MeSH
- prediktivní hodnota testů MeSH
- reprodukovatelnost výsledků MeSH
- senioři MeSH
- senzitivita a specificita MeSH
- tlakový index kotník-paže přístrojové vybavení MeSH
- ultrasonografie dopplerovská přístrojové vybavení MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- validační studie MeSH
- Geografické názvy
- Česká republika MeSH