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Autor
Chen, Jun 1 Chen, Xianfeng 1 Chia, Nicholas 1 Jeraldo, Patricio R 1 Kalari, Krishna R 1 Kantarci, Orhun H 1 Luckey, David H 1 Mangalam, Ashutosh K 1 Marietta, Eric V 1 Murray, Joseph A 1 Nelson, Heidi 1 Novotna, Martina 1 Paz Soldan, M Mateo 1 Rodriguez, Moses 1 Weinshenker, Brian G 1 Yao, Janet Z 1
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Pracoviště
Department of Biophysics Mayo Clinic ... 1 Department of Gastroenterology Mayo C... 1 Department of Immunology Mayo Clinic ... 1 Department of Pathology 25 S Grand Av... 1 Department of Surgical Research Mayo ... 1 Division of Biomedical Statistics and... 1 International Clinical Research Cente... 1 Mayo Clinic Center for Multiple Scler... 1
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- Jazyk
- Země
- Časopis/zdroj
- Nejvíce citované
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Autor
Chen, Jun 1 Chen, Xianfeng 1 Chia, Nicholas 1 Jeraldo, Patricio R 1 Kalari, Krishna R 1 Kantarci, Orhun H 1 Luckey, David H 1 Mangalam, Ashutosh K 1 Marietta, Eric V 1 Murray, Joseph A 1 Nelson, Heidi 1 Novotna, Martina 1 Paz Soldan, M Mateo 1 Rodriguez, Moses 1 Weinshenker, Brian G 1 Yao, Janet Z 1
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Pracoviště
Department of Biophysics Mayo Clinic ... 1 Department of Gastroenterology Mayo C... 1 Department of Immunology Mayo Clinic ... 1 Department of Pathology 25 S Grand Av... 1 Department of Surgical Research Mayo ... 1 Division of Biomedical Statistics and... 1 International Clinical Research Cente... 1 Mayo Clinic Center for Multiple Scler... 1
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Nejvíce citované
- Chen, Jun
- Chia, Nicholas
- Kalari, Krishna R
- Yao, Janet Z
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Novotna, Martina
Autor Novotna, Martina Mayo Clinic Center for Multiple Sclerosis and CNS Demyelinating Diseases, Department of Neurology, Mayo Clinic College of Medicine, 200 1st ST SW, Rochester, MN-55905, USA International Clinical Research Center, St. Anne's University Hospital Brno, Pekařská 53, 656 91 Brno, Czech Republic
- Paz Soldan, M Mateo
- Luckey, David H
- Marietta, Eric V
- Jeraldo, Patricio R
- Chen, Xianfeng
PubMed
27346372
PubMed Central
PMC4921909
DOI
10.1038/srep28484
PII: srep28484
Knihovny.cz E-zdroje
Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3-V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.
- MeSH
- dospělí MeSH
- dysbióza mikrobiologie MeSH
- gastrointestinální trakt mikrobiologie MeSH
- lidé MeSH
- mikrobiota genetika MeSH
- RNA ribozomální 16S genetika MeSH
- roztroušená skleróza mikrobiologie MeSH
- střevní mikroflóra genetika MeSH
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- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- RNA ribozomální 16S MeSH
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